Inflammatory and non-inflammatory monocytes as novel prognostic biomarkers of survival in SOD1G93A mouse model of Amyotrophic Lateral Sclerosis.

Autor: Samanta Gasco, Pilar Zaragoza, Alberto García-Redondo, Ana C Calvo, Rosario Osta

Publikováno v: PLoS ONE, Vol 12, Iss 9, p e0184626 (2017)

Amyotrophic Lateral Sclerosis (ALS) has lately become a suitable scenario to study the interplay between the hematopoietic system and disease progression. Recent studies in C9orf72 null mice have demonstrated that C9orf72 is necessary for the normal

Externí odkaz: https://doaj.org/article/c44a9471c4aa4f0daf3689882558c3c3

Genetic biomarkers for ALS disease in transgenic SOD1(G93A) mice.

Autor: Ana C Calvo, Raquel Manzano, Gabriela Atencia-Cibreiro, Sara Oliván, María J Muñoz, Pilar Zaragoza, Pilar Cordero-Vázquez, Jesús Esteban-Pérez, Alberto García-Redondo, Rosario Osta

Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32632 (2012)

The pathophysiological mechanisms of both familial and sporadic Amyotrophic Lateral Sclerosis (ALS) are unknown, although growing evidence suggests that skeletal muscle tissue is a primary target of ALS toxicity. Skeletal muscle biopsies were perform

Externí odkaz: https://doaj.org/article/0b29545086dd470c8e4430df219cdfb0

What skeletal muscle has to say in amyotrophic lateral sclerosis: Implications for therapy

Autor: Laura Moreno-Martínez, Ana C. Calvo, Miriam de la Torre, Tresa López-Royo, Leticia Moreno-García, Pilar Zaragoza, Nora Molina, Raquel Manzano, Rosario Osta, Janne M. Toivonen

Publikováno v: British Journal of Pharmacology. 178:1279-1297

Amyotrophic lateral sclerosis (ALS) is an adult onset disorder characterized by progressive neuromuscular junction (NMJ) dismantling and degeneration of motor neurons leading to atrophy and paralysis of voluntary muscles responsible for motion and br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39804cc48c568affb9a8df25c4bfa3f2
https://doi.org/10.1111/bph.15276

Inflammasome in als skeletal muscle: Nlrp3 as a potential biomarker

Autor: Laura Moreno-Martínez, Rosario Osta, Christian Lunetta, Ana C. Calvo, Pilar Zaragoza, Claudia Tarlarini, Leticia Moreno-García, Miriam de la Torre, F. J. Miana-Mena

Publikováno v: International Journal of Molecular Sciences
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname
Volume 22
Issue 5
International Journal of Molecular Sciences, Vol 22, Iss 2523, p 2523 (2021)
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza

Since NLRP3 inflammasome plays a pivotal role in several neurodegenerative disorders, we hypothesized that levels of inflammasome components could help in diagnosis or prognosis of amyotrophic lateral sclerosis (ALS). Gene and protein expression was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90509c8664bc15d0786d62dd77fab7e
http://zaguan.unizar.es/record/102175

Neuroprotective fragment C of tetanus toxin modulates IL-6 in an ALS mouse model

Autor: Rosario Osta, Laura Moreno-Martínez, Pilar Zaragoza, José Aguilera, Miriam de la Torre, Ana C. Calvo, María Jesús Muñoz

Publikováno v: Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Zaguán: Repositorio Digital de la Universidad de Zaragoza
Universidad de Zaragoza
Toxins
Toxins, Vol 12, Iss 330, p 330 (2020)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
instname

Neuroinflammation plays a significant role in amyotrophic lateral sclerosis (ALS) pathology, leading to the development of therapies targeting inflammation in recent years. Our group has studied the tetanus toxin C-terminal fragment (TTC) as a therap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad78cd56fb0db1ab9572d59c0271e4b
https://ddd.uab.cat/record/241234