Htt is a repressor of Abl activity required for APP-induced axonal growth.

Autor: Claire Marquilly, Germain U Busto, Brittany S Leger, Ana Boulanger, Edward Giniger, James A Walker, Lee G Fradkin, Jean-Maurice Dura

Publikováno v: PLoS Genetics, Vol 17, Iss 1, p e1009287 (2021)

Huntington's disease is a progressive autosomal dominant neurodegenerative disorder caused by the expansion of a polyglutamine tract at the N-terminus of a large cytoplasmic protein. The Drosophila huntingtin (htt) gene is widely expressed during all

Externí odkaz: https://doaj.org/article/efc38108467142319cba47af0ac17410

Drosophila motor neuron retraction during metamorphosis is mediated by inputs from TGF-β/BMP signaling and orphan nuclear receptors.

Autor: Ana Boulanger, Morgane Farge, Christophe Ramanoudjame, Kristi Wharton, Jean-Maurice Dura

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e40255 (2012)

Larval motor neurons remodel during Drosophila neuro-muscular junction dismantling at metamorphosis. In this study, we describe the motor neuron retraction as opposed to degeneration based on the early disappearance of β-Spectrin and the continuing

Externí odkaz: https://doaj.org/article/369398bfba99415cac185fcb93347610

Neuron-glia crosstalk in neuronal remodeling and degeneration: Neuronal signals inducing glial cell phagocytic transformation in Drosophila

Autor: Jean-Maurice Dura, Ana Boulanger Soto-Prior

Publikováno v: BioEssays : news and reviews in molecular, cellular and developmental biologyREFERENCES. 44(5)

Neuronal remodeling is a conserved mechanism that eliminates unwanted neurites and can include the loss of cell bodies. In these processes, a key role for glial cells in events from synaptic pruning to neuron elimination has been clearly identified i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9017040f9e3bc1dde2d730b718a4ea15
https://pubmed.ncbi.nlm.nih.gov/35315125

Axonal chemokine-like Orion induces astrocyte infiltration and engulfment during mushroom body neuronal remodeling

Autor: Stephan Züchner, Lee G. Fradkin, Ana Boulanger, Jean Maurice Dura, Camille Thinat, Hugues Lortat-Jacob

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.1849. ⟨10.1038/s41467-021-22054-x⟩
Nature Communications, 2021, 12 (1), pp.1849. ⟨10.1038/s41467-021-22054-x⟩

The remodeling of neurons is a conserved fundamental mechanism underlying nervous system maturation and function. Astrocytes can clear neuronal debris and they have an active role in neuronal remodeling. Developmental axon pruning of Drosophila memor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6153a71de269491e8e61e23762120235
https://doi.org/10.1038/s41467-021-22054-x

HTT is a repressor of ABL activity required for APP induced axonal growth

Autor: Lee G. Fradkin, Jean-Maurice Dura, Brittany S. Leger, Ana Boulanger, Germain U. Busto, Claire Marquilly, James A. Walker, Edward Giniger

Publikováno v: PLoS Genetics
PLoS Genetics, Public Library of Science, 2021, 17 (1), pp.e1009287. ⟨10.1371/journal.pgen.1009287⟩
PLoS Genetics, Vol 17, Iss 1, p e1009287 (2021)

Huntington’s disease is a progressive autosomal dominant neurodegenerative disorder caused by the expansion of a polyglutamine tract at the N-terminus of a large cytoplasmic protein. The Drosophila huntingtin (htt) gene is widely expressed during a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64396ad1ad999b4c6e36846bd94293a
https://hal.archives-ouvertes.fr/hal-02401010/document