Výsledky vyhledávání - "Ana Belen Salinas-Abarca"

Interaction of NHE1 and TRPA1 Activity in DRG Neurons Isolated from Adult Rats and its Role in Inflammatory Nociception

Autor: Norma L. Gómez-Viquez, Francisco Mercado, Vinicio Granados-Soto, Janet Murbartián, Vladimir A. Martínez-Rojas, Ana Belen Salinas-Abarca

Publikováno v: Neuroscience. 465:154-165

Transient receptor potential ankyrin 1 (TRPA1) channel is expressed in a subset of nociceptive neurons. This channel integrates several nociceptive signals. Particularly, it is modulated by intracellular pH (pHi). Na+/H+ exchanger 1 (NHE1) contribute

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5a9ecc2cb5892e59c3415e9ee2476e
https://doi.org/10.1016/j.neuroscience.2021.04.025

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Sex‐dependent pronociceptive role of spinal α 5 ‐GABA A receptor and its epigenetic regulation in neuropathic rodents

Autor: Úrzula Franco-Enzástiga, Rodolfo Delgado-Lezama, Rodrigo González-Barrios, Vinicio Granados-Soto, Beatriz Sánchez‐Hernández, Theodore J. Price, Diana Tavares-Ferreira, Luis A. Herrera, Paulino Barragán-Iglesias, Ana Belen Salinas-Abarca, Guadalupe García, Janet Murbartián

Publikováno v: Journal of Neurochemistry. 156:897-916

Extrasynaptic α5 -subunit containing GABAA (α5 -GABAA ) receptors participate in chronic pain. Previously, we reported a sex difference in the action of α5 -GABAA receptors in dysfunctional pain. However, the underlying mechanisms remain unknown.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df59e1ee0551f1329d2005b3384a617c
https://doi.org/10.1111/jnc.15140

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Sex-dependent antiallodynic effect of α

Autor: Erick Josué, Rodríguez-Palma, Dania Guadalupe, Castelo-Flores, Nadia Lizeth, Caram-Salas, Ana Belen, Salinas-Abarca, David, Centurión, Yarim Elideth, De la Luz-Cuellar, Vinicio, Granados-Soto

Publikováno v: European journal of pharmacology. 920

The purpose of this study was to investigate the mechanism of antiallodynic effect of tizanidine in neuropathic rats. Spinal nerve ligation reduced withdrawal threshold which was interpreted as tactile allodynia. Increasing doses of tizanidine induce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b48e0bbf581f8cff5837442b3f96650
https://pubmed.ncbi.nlm.nih.gov/35227682

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α5GABAA receptors play a pronociceptive role and avoid the rate-dependent depression of the Hoffmann reflex in diabetic neuropathic pain and reduce primary afferent excitability

Autor: David Elías-Viñas, Rodolfo Delgado-Lezama, Guadalupe C. Vidal-Cantú, José E Hernández-Reyes, Ana Belen Salinas-Abarca, Guadalupe Raya-Tafolla, Vinicio Granados-Soto

Publikováno v: Pain. 160:1448-1458

Diabetic neuropathy is an incapacitating complication in diabetic patients. The cellular and molecular mechanisms involved in this pathology are poorly understood. Previous studies have suggested that the loss of spinal GABAergic inhibition participa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4c97d6ddafa7b646d6cc4029d850eb8
https://doi.org/10.1097/j.pain.0000000000001515

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Evaluation of the neonatal streptozotocin model of diabetes in rats: Evidence for a model of neuropathic pain

Autor: Theodore J. Price, Rodolfo Delgado-Lezama, Vinicio Granados-Soto, Isabel Velazquez-Lagunas, Paulino Barragán-Iglesias, Víctor Hugo Oidor-Chan, Jorge Baruch Pineda-Farias, Emanuel Loeza-Alcocer, Ana Belen Salinas-Abarca, Enrique Hong, Alicia Sánchez-Mendoza

Publikováno v: Pharmacological Reports. 70:294-303

Background The purpose of this study was to evaluate the participation of satellite glial cells (SGC), microglia and astrocytes in a model of streptozotocin-induced diabetes initiated in neonatal rats (nSTZ) and to determine the pharmacological profi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70cbe17f9a590d4ed40913a00423c971
https://doi.org/10.1016/j.pharep.2017.09.002

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Ultra-Low Doses of Naltrexone Enhance the Antiallodynic Effect of Pregabalin or Gabapentin in Neuropathic Rats

Autor: Vinicio Granados-Soto, Jorge Ocampo, Jorge Baruch Pineda-Farias, Nadia L. Caram-Salas, Ana Belen Salinas-Abarca

Publikováno v: Drug Development Research. 78:371-380

Preclinical Research Treatment of neuropathic pain is an area of largely unmet medical need. Pregabalin and gabapentin are anticonvulsants widely used for the treatment of neuropathic pain. Unfortunately, these drugs are only effective in 50-60% of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::12391e20ee740df29dff74a5a5b033ee
https://doi.org/10.1002/ddr.21409

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Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain

Autor: Guadalupe C. Vidal-Cantú, Vinicio Granados-Soto, Gregory Dussor, Theodore J. Price, Ana Belen Salinas-Abarca, Jasper L. Kuhn, Paulino Barragán-Iglesias, Zachary T. Campbell

Methylglyoxal (MGO) is a reactive glycolytic metabolite associated with painful diabetic neuropathy at plasma concentration is between 500 nM and 5 μM. The mechanisms through which MGO causes neuropathic pain at these pathological concentrations are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::311c9426409fb37b667869730f8d1ed6
https://europepmc.org/articles/PMC6800106/

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Role of spinal 5-HT5A, and 5-HT1A/1B/1D, receptors in neuropathic pain induced by spinal nerve ligation in rats

Autor: Jorge Baruch Pineda-Farias, Vinicio Granados-Soto, Isabel Velazquez-Lagunas, Sabino Hazael Avila-Rojas, Ana Belen Salinas-Abarca, Paulino Barragán-Iglesias

Publikováno v: Brain Research. 1622:377-385

Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT receptors. The role of 5-HT5A receptor in neuropathic pain has not previously studied. The purpose of this study was to investigate: A) the role of 5-HT5A receptors i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2947f7a4fe206b28c7c770d037ca65b5
https://doi.org/10.1016/j.brainres.2015.06.043

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