Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Ana Belén Elgoyhen"'
Autor:
Ana Belén Elgoyhen
Publikováno v:
Pharmacological Research, Vol 190, Iss , Pp 106735- (2023)
Within the superfamily of pentameric ligand-gated ion channels, cholinergic nicotinic receptors (nAChRs) were classically identified to mediate synaptic transmission in the nervous system and the neuromuscular junction. The α9 and α10 nAChR subunit
Externí odkaz:
https://doaj.org/article/d65033d59f744890b6554ab775e5cb6f
Autor:
Paula I. Buonfiglio, Carlos D. Bruque, Vanesa Lotersztein, Leonela Luce, Florencia Giliberto, Sebastián Menazzi, Liliana Francipane, Bibiana Paoli, Ernesto Goldschmidt, Ana Belén Elgoyhen, Viviana Dalamón
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Hearing loss is a heterogeneous disorder. Identification of causative mutations is demanding due to genetic heterogeneity. In this study, we investigated the genetic cause of sensorineural hearing loss in patients with severe/profound deafne
Externí odkaz:
https://doaj.org/article/566dfa2b97ec4284a3729f4ceba24c83
Autor:
Paula I Buonfiglio, Sebastián Menazzi, Liliana Francipane, Vanesa Lotersztein, Verónica Ferreiro, Ana Belén Elgoyhen, Viviana Dalamón
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0275703 (2023)
The present study investigates the spectrum and analysis of mitochondrial DNA (mtDNA) variants associated with Leber hereditary optic neuropathy (LHON) in an Argentinean cohort, analyzing 3 LHON-associated mitochondrial genes. In 32% of the cases, mo
Externí odkaz:
https://doaj.org/article/04b1d51d71b943c4994e8b5d73d874df
Autor:
Daniela Chequer Charan, Yunfeng Hua, Haoyu Wang, Wenqing Huang, Fangfang Wang, Ana Belén Elgoyhen, Kevin M. Boergens, Mariano N. Di Guilmi
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
The medial nucleus of the trapezoid body (MNTB) is an integral component of the auditory brainstem circuitry involved in sound localization. The giant presynaptic nerve terminal with multiple active zones, the calyx of Held (CH), is a hallmark of thi
Externí odkaz:
https://doaj.org/article/c43b39a5bedb42c7b94773a10815f47d
Autor:
Bruno Hernandez-Cravero, Sofia Gallino, Jeremy Florman, Cecilia Vranych, Philippe Diaz, Ana Belén Elgoyhen, Mark J Alkema, Diego de Mendoza
Publikováno v:
PLoS Genetics, Vol 18, Iss 11, p e1010346 (2022)
The nematode Caenorhabditis elegans requires exogenous cholesterol to survive and its depletion leads to early developmental arrest. Thus, tight regulation of cholesterol storage and distribution within the organism is critical. Previously, we demons
Externí odkaz:
https://doaj.org/article/ffb746efddee491aab419cf91b15ab99
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion channels with members identified in most eumetazoan clades. In vertebrates, they are divided into three subgroups, according to their main tissue of expression:
Externí odkaz:
https://doaj.org/article/384ea5f2849d484b880d0b9819c7c7e5
Autor:
Paola V. Plazas, Ana Belén Elgoyhen
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Vertebrate hair cell (HC) systems are innervated by efferent fibers that modulate their response to external stimuli. In mammals, the best studied efferent-HC synapse, the cholinergic medial olivocochlear (MOC) efferent system, makes direct synaptic
Externí odkaz:
https://doaj.org/article/a70af2b0e25e4709826f0bceb7a418dc
Autor:
Marcelo J. Moglie, Irina Marcovich, Jeremías Corradi, Agustín E. Carpaneto Freixas, Sofía Gallino, Paola V. Plazas, Cecilia Bouzat, Marcela Lipovsek, Ana Belén Elgoyhen
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
The α9α10 nicotinic acetylcholine receptor (nAChR) plays a fundamental role in inner ear physiology. It mediates synaptic transmission between efferent olivocochlear fibers that descend from the brainstem and hair cells of the auditory sensory epit
Externí odkaz:
https://doaj.org/article/146ff47d27844178bd2cf40200521dc2
Autor:
Marcela Lipovsek, Ana Belén Elgoyhen
Publikováno v:
Trends in Neurosciences. 46:110-123
After the transition to life on land, tympanic middle ears emerged separately in different groups of tetrapods, facilitating the efficient detection of airborne sounds and paving the way for high frequency sensitivity. The processes that brought abou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba7aa7d99c03dcd61b98a0b82dab404
https://doi.org/10.1016/j.tins.2022.12.002
https://doi.org/10.1016/j.tins.2022.12.002
Autor:
Ana Belén Elgoyhen
Publikováno v:
Expert Opin Ther Targets
INTRODUCTION: Hearing loss is a major health problem, impacting education, communication, interpersonal relationships, and mental health. Drugs that prevent or restore hearing are lacking and hence novel drug targets are sought. There is the possibil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e6ac91414fa576a82a4a9e097fede1
https://pubmed.ncbi.nlm.nih.gov/35225139
https://pubmed.ncbi.nlm.nih.gov/35225139