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Autor:
Ivan Collado, Eric D. Moher, Joseph P. Tizzano, Concepcion Pedregal, David W. Hoard, T. Rosario Gonzalez, Jaime Blanco-Urgoiti, Rebecca A. Wright, Darryle Darwin Schoepp, Javier Pérez-Castells, Kelly I. Griffey, Alicia Marcos, Ana Belén Bueno, Ann E. Kingston, Bryan G. Johnson
Publikováno v:
Journal of medicinal chemistry. 47(2)
The asymmetric synthesis and biological activity of (2S,1‘S,2‘R,3‘R)-2-(2‘-carboxy-3‘-hydroxymethylcyclopropyl) glycine ((+)-3) is described. This novel C-3‘ substituted carboxy cyclopropyl glycine is a highly potent group 2 and group 3 m