Výsledky vyhledávání - "Ana Alfonso-Piérola"

Akademický článek

The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Acute myeloid leukemia (AML) in the elderly remains a clinical challenge, with a five-year overall survival rate below 10%. The current ELN 2017 genetic risk classification considers cytogenetic and mutational characteristics to stratify fit AML pati

Externí odkaz: https://doaj.org/article/3518c66232c441da81dbca6328896425

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A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes

Autor: Giulia Maggioni, Matteo Bersanelli, Erica Travaglino, Ana Alfonso Piérola, Annika Kasprzak, Arnan Sangerman Montserrat, Elisabetta Sauta, Claudia Sala, Tommaso Matteuzzi, Manja Meggendorfer, Matteo Gnocchi, Lin-Pierre Zhao, Cristina Astrid Tentori, Kathrin Nachtkamp, Daniele Dall'Olio, Ettore Mosca, Marta Ubezio, Alessia Campagna, Antonio Russo, Giulia Rivoli, Massimo Bernardi, Lorenza Borin, Maria Teresa Voso, Marta Riva, Esther Oliva, Matteo Zampini, Elena Riva, Elena Saba, Saverio D'Amico, Luca Lanino, Benedetta Tinterri, Francesca Re, Marilena Bicchieri, Laura Giordano, Giovanni Angelotti, Pierandrea Morandini, Anne Sophie Kubasch, Francesco Passamonti, Alessandro Rambaldi, Victor Savevski, Armando Santoro, Arjan A. van de Loosdrecht, Alice Brogi, Valeria Santini, Shahram Kordasti, Guillermo Sanz, Francesc Sole, Norbert Gattermann, Wolfgang Kern, Uwe Platzbecker, Lionel Ades, Pierre Fenaux, Torsten Haferlach, Gastone Castellani, Ulrich Germing, Maria Diez-Campelo, Matteo G. Della Porta

Publikováno v: GenoMed4All consortium 2023, ' A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes : a multicentre, observational cohort study ', The Lancet Haematology, vol. 10, no. 2, pp. e117-e128 . https://doi.org/10.1016/S2352-3026(22)00323-4
The Lancet Haematology, 10(2), e117-e128. Lancet Publishing Group

Background Sex is a major source of diversity among patients and a sex-informed approach is becoming a new paradigm in precision medicine. We aimed to describe sex diversity in myelodysplastic syndromes in terms of disease genotype, phenotype, and cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::503395a18d54ac04f5422062d52b818c
https://doi.org/10.1016/s2352-3026(22)00323-4

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Updates on the Management of Acute Myeloid Leukemia

Autor: Sofía Huerga-Domínguez, Sara Villar, Felipe Prósper, Ana Alfonso-Piérola

Publikováno v: Cancers. 14(19)

Acute myeloid leukemia is a heterogeneous disease defined by a large spectrum of genetic aberrations that are potential therapeutic targets. New targeted therapies have changed the landscape for a disease with poor outcomes. They are more effective t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::948dd9ef35e9e17b492ae95399e17d7c
https://pubmed.ncbi.nlm.nih.gov/36230677

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Akademický článek

Epigenetic-based differentiation therapy for Acute Myeloid Leukemia

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)

Abstract Despite the development of novel therapies for acute myeloid leukemia, outcomes remain poor for most patients, and therapeutic improvements are an urgent unmet need. Although treatment regimens promoting differentiation have succeeded in the

Externí odkaz: https://doaj.org/article/c19f4277205c445384d53303bce19ff2

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Akademický článek

Single-cell transcriptional profile of CD34+ hematopoietic progenitor cells from del(5q) myelodysplastic syndromes and impact of lenalidomide

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract While myelodysplastic syndromes with del(5q) (del(5q) MDS) comprises a well-defined hematological subgroup, the molecular basis underlying its origin remains unknown. Using single cell RNA-seq (scRNA-seq) on CD34+ progenitors from del(5q) MD

Externí odkaz: https://doaj.org/article/91536052d5734ebda987ce77dddb892b

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Akademický článek

Uncovering perturbations in human hematopoiesis associated with healthy aging and myeloid malignancies at single-cell resolution

Publikováno v: eLife, Vol 12 (2023)

Early hematopoiesis is a continuous process in which hematopoietic stem and progenitor cells (HSPCs) gradually differentiate toward specific lineages. Aging and myeloid malignant transformation are characterized by changes in the composition and regu

Externí odkaz: https://doaj.org/article/3e9c063b4a474f658aaf2538b69955f6

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Akademický článek

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