Preparation of an advanced intermediate for the synthesis of leustroducsins and phoslactomycins by heterocycloaddition

Autor: Anaïs Rousseau, Guillaume Vincent, Cyrille Kouklovsky

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 18, Iss 1, Pp 1385-1395 (2022)

A convergent strategy for the synthesis of leustroducsins and phoslactomycins has been designed, relying on the synthesis and the coupling of three main fragments. The central fragment was synthesized via a regio-and stereoselective nitroso Diels–A

Externí odkaz: https://doaj.org/article/da282619b5324a4d9c099d09a59b82ff

Impact of cathepsin B-sensitive triggers and hydrophilic linkers onin vitroefficacy of novel site-specific antibody–drug conjugates

Autor: Nicolas Joubert, Stéphanie Letast, Cyril Colas, Marie-Claude Viaud-Massuard, Eva Lles, Camille Martin, Christel Larbouret, Inmaculada Viéitez-Villemin, Emilie Allard-Vannier, Anaïs Rousseau, Marie Brachet-Botineau, Francesca Bryden

Publikováno v: Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2018, 16 (11), pp.1882-1889. ⟨10.1039/c7ob02780j⟩
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (11), pp.1882-1889. 〈10.1039/c7ob02780j〉
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2018, 16 (11), pp.1882-1889. ⟨10.1039/c7ob02780j⟩

Herein we describe the synthesis and evaluation of four novel HER2-targeting, cathepsin B-sensitive antibody-drug conjugates bearing a monomethylauristatin E (MMAE) cytotoxic payload, constructed via the conjugation of cleavable linkers to trastuzuma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a68e540255ee8e685d66c7de56ab664
https://doi.org/10.1039/c7ob02780j

Prebiotic Supplementation During Gestation Induces a Tolerogenic Environment and a Protective Microbiota in Offspring Mitigating Food Allergy

Autor: Amandine Selle, Carole Brosseau, Wieneke Dijk, Angéline Duval, Grégory Bouchaud, Anais Rousseaux, Aurélia Bruneau, Claire Cherbuy, Mahendra Mariadassou, Véronique Cariou, Sebastien Barbarot, Marie Bodinier

Publikováno v: Frontiers in Immunology, Vol 12 (2022)

Food allergy is associated with alterations in the gut microbiota, epithelial barrier, and immune tolerance. These dysfunctions are observed within the first months of life, indicating that early intervention is crucial for disease prevention. Preven

Externí odkaz: https://doaj.org/article/353848a6665a4f978d69d365ddcf1881

Human Milk Oligosaccharides: Their Effects on the Host and Their Potential as Therapeutic Agents

Autor: Anaïs Rousseaux, Carole Brosseau, Sophie Le Gall, Hugues Piloquet, Sébastien Barbarot, Marie Bodinier

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Breastmilk is known to be very important for infants because it provides nutrients and immunological compounds. Among these compounds, human milk oligosaccharides (HMOs) represent the third most important component of breastmilk after lipids and lact

Externí odkaz: https://doaj.org/article/3b6db61367c140d1a866f4dad0eda483