Výsledky vyhledávání - "Anaïs Lopez"

Akademický článek

Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo

Autor: Hassan Javanbakht, Henrik Mueller, Johanna Walther, Xue Zhou, Anaïs Lopez, Thushara Pattupara, Julie Blaising, Lykke Pedersen, Nanna Albæk, Malene Jackerott, Tianlai Shi, Corinne Ploix, Wouter Driessen, Robert Persson, Jacob Ravn, John A.T. Young, Søren Ottosen

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 441-454 (2018)

Chronic hepatitis B infection (CHB) is an area of high unmet medical need. Current standard-of-care therapies only rarely lead to a functional cure, defined as durable hepatitis B surface antigen (HBsAg) loss following treatment. The goal for next ge

Externí odkaz: https://doaj.org/article/1962d4b211f2443bb9955ca1ed51da8a

Zobrazit plný text záznamu

PAPD5/7 Are Host Factors That Are Required for Hepatitis B Virus RNA Stabilization

Autor: Josephine Schmaler, John A. T. Young, Philipp Tropberger, Xingchun Han, Henrik Mueller, Søren Ottosen, Lykke Pedersen, Hassan Javanbakht, Song Yang, Steffen Wildum, Yongguang Wang, Anaïs Lopez

Publikováno v: Hepatology. 69:1398-1411

RG7834 is a potent, orally bioavailable small-molecule inhibitor of hepatitis B virus (HBV) gene expression that belongs to the dihydroquinolizinone (DHQ) chemical class and uniquely blocks production of both viral DNA and antigens. In this study, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8663aa0e5a0ff46c46c2c2542635ea1
https://doi.org/10.1002/hep.30329

Zobrazit plný text záznamu

Down-regulation of the Wnt/β-catenin signaling pathway by Cacnb4

Autor: Juan L. Brusés, Yasuo Mori, Michel Ronjat, Lydie Lefrançois, Michel De Waard, Mohamad Rima, Anaïs Lopez, Philippe Merle, Marwa Daghsni, Mireia Duñach, Ziad Fajloun

Publikováno v: Recercat. Dipósit de la Recerca de Catalunya
instname
Recercat: Dipósit de la Recerca de Catalunya
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Molecular Biology of the Cell
Molecular Biology of the Cell, 2017, Equipe IIb, 28 (25), pp.3699--3708. ⟨10.1091/mbc.E17-01-0076⟩
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Molecular Biology of the Cell, American Society for Cell Biology, 2017, Equipe IIb, 28 (25), pp.3699--3708. ⟨10.1091/mbc.E17-01-0076⟩

The cytoplasmic β4-subunit of the voltage-gated calcium channels has been shown be involved in the regulation of gene transcription. This subunit interacts with the transcription factor TCF4 and inhibits the Wnt/β-catenin signaling pathway. These r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76231d0bbcbb922bc276adff93e77c6f
http://hdl.handle.net/2072/428227

Zobrazit plný text záznamu

Liver-Targeted Anti-HBV Single-Stranded Oligonucleotides with Locked Nucleic Acid Potently Reduce HBV Gene Expression In Vivo

Autor: Lykke Pedersen, Robert Persson, Corinne Ploix, Xue Zhou, John A. T. Young, Thushara Pattupara, Hassan Javanbakht, Tianlai Shi, Johanna Walther, Julie Elisabeth Françoise Blaising, Henrik Mueller, Wouter H. P. Driessen, Nanna Albæk, Jacob Ravn, Anaïs Lopez, Søren Ottosen, Malene Jackerott

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 11, Iss C, Pp 441-454 (2018)
Molecular Therapy. Nucleic Acids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7f5e083b00161c949a8777063fcc7d
https://doi.org/10.1016/j.omtn.2018.02.005

Zobrazit plný text záznamu

A novel orally available small molecule that inhibits hepatitis B virus expression

Publikováno v: Journal of Hepatology. 68:412-420

Background & Aims The hallmarks of chronic HBV infection are a high viral load (HBV DNA) and even higher levels (>100-fold in excess of virions) of non-infectious membranous particles containing the tolerogenic viral S antigen (HBsAg). Currently, sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d84702acffd3eccf3b1391dd2397f1
https://doi.org/10.1016/j.jhep.2017.10.014

Zobrazit plný text záznamu

In vitro transformation of primary human hepatocytes: Epigenetic changes and stemness properties

Autor: Philippe Merle, Davide Degli-Esposti, Claude Caron de Fromentel, Maud Michelet, Patricia Gifu, Bakary S. Sylla, Anaïs Lopez, Floriane Pez, Nadim Fares, Zdenko Herceg, Lydie Lefrançois, Brigitte Bancel, Michel Rivoire

Publikováno v: Experimental Cell Research
Experimental Cell Research, Elsevier, 2019, 384, pp.111643-. ⟨10.1016/j.yexcr.2019.111643⟩

Human hepatocarcinogenesis is a complex process with many unresolved issues, including the cell of origin (differentiated and/or progenitor/stem cells) and the initial steps leading to tumor development. With the aim of providing new tools for studyi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a94128130d290f5ec1e0296bb5df31
https://doi.org/10.1016/j.yexcr.2019.111643

Zobrazit plný text záznamu

Wnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs

Autor: Anaïs Lopez, Claude Caron de Fromentel, Miran Kim, Jack R. Wands, Philippe Merle, Floriane Pez

Publikováno v: Journal of Hepatology. 59(5):1107-1117

SummaryHepatocellular carcinoma (HCC) is one of the most common causes of cancer death worldwide. HCC can be cured by radical therapies if early diagnosis is done while the tumor has remained of small size. Unfortunately, diagnosis is commonly late w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e81dd5ed10fb1d2a17e90d676c9693f

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání