Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Anaïs F. M. Noisier"'
Autor:
Ingrid R. Vetter, Hélène Adihou, Darijan Schüler, Arthur T. Porfetye, Adrian Krzyzanowski, Mohammad Akbarzadeh, Herbert Waldmann, Pascal Hommen, Anaïs F. M. Noisier, Peter 't Hart
Publikováno v:
Angewandte Chemie (International Ed. in English)
The scaffolding protein RbAp48 is part of several epigenetic regulation complexes and is overexpressed in a variety of cancers. In order to develop tool compounds for the study of RbAp48 function, we have developed peptide inhibitors targeting the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d91f25d5e8c892feb22612352f6f86
https://doi.org/10.1002/ange.202009749
https://doi.org/10.1002/ange.202009749
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2355
Synthetic molecular probes have recently been in focus for their potential use in target deconvolution, target engagement studies, and imaging. With the field expanding, new strategies to develop such tools are in high demand. While traditional conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2d22cf45c5677dad97170bc7491ece5
https://pubmed.ncbi.nlm.nih.gov/34386948
https://pubmed.ncbi.nlm.nih.gov/34386948
Autor:
Ranganath Gopalakrishnan, Anaïs F. M. Noisier, Martin A. Hayes, Lara R. Malins, Magnus Johansson, William J. Drury, Eric Valeur, Laurent Knerr
Publikováno v:
Angewandte Chemie. 131:19272-19278
The late-stage functionalization (LSF) of peptides represents a valuable strategy for the design of potent peptide pharmaceuticals by enabling rapid exploration of chemical diversity and offering novel opportunities for peptide conjugation. While the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::075503324188482e802a84db634108cb
https://doi.org/10.1002/ange.201910888
https://doi.org/10.1002/ange.201910888
Publikováno v:
Methods in Molecular Biology ISBN: 9781071616161
Synthetic molecular probes have recently been in focus for their potential use in target deconvolution, target engagement studies, and imaging. With the field expanding, new strategies to develop such tools are in high demand. While traditional conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::478da3f64a8c6ccc293dfa2b0ff57230
https://doi.org/10.1007/978-1-0716-1617-8_4
https://doi.org/10.1007/978-1-0716-1617-8_4
Publikováno v:
Angewandte Chemie International Edition. 56:314-318
Despite the importance of stapled peptides for drug discovery, only few practical processes to prepare cross-linked peptides have been described; thus the structural diversity of available staple motifs is currently limited. At the same time, C-H act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c081014dd8392f4774af787bebaf2993
https://doi.org/10.1002/anie.201608648
https://doi.org/10.1002/anie.201608648
Publikováno v:
Angewandte Chemie. 129:320-324
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa8bb056ee5dc28ae81870d1cc06c0a
https://doi.org/10.1002/ange.201608648
https://doi.org/10.1002/ange.201608648
Autor:
Kuo-yuan Hung, Margaret A. Brimble, Jörg W. Bartsch, Anaïs F. M. Noisier, Victor Yim, Uwe Schlomann
Publikováno v:
Bioorganic & Medicinal Chemistry. 24:4032-4037
The metalloproteinase ADAM8 serves as a pivotal catalyst in the development of inflammatory diseases and cancer metastasis. The cyclic peptide cyclo(RLsKDK) has been shown to inhibit the enzymatic activity of ADAM8 with high specificity and potency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b2ef558fd79d35116721faa64f17fb
https://doi.org/10.1016/j.bmc.2016.06.042
https://doi.org/10.1016/j.bmc.2016.06.042
Publikováno v:
European Journal of Organic Chemistry. 2014:1195-1201
Due to their numerous applications, fluorinated amino acids have recently attracted significant attention. The preparation of fluorine-containing phenylalanines, heteroaryl alanines and aliphatic fluorinated amino acids using Mitsunobu–Tsunoda alky
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5e567069e1eb1570926458d4ef74909
https://doi.org/10.1002/ejoc.201301718
https://doi.org/10.1002/ejoc.201301718
Publikováno v:
Angewandte Chemie (International ed. in English). 56(1)
Despite the importance of stapled peptides for drug discovery, only few practical processes to prepare cross-linked peptides have been described; thus the structural diversity of available staple motifs is currently limited. At the same time, C-H act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9cca316d4a4e50f640751e543e71943a
https://pubmed.ncbi.nlm.nih.gov/27900857
https://pubmed.ncbi.nlm.nih.gov/27900857
Autor:
Benedicte Delouvrie, Craig S. Harris, Honorine Lebraud, Maryannick Lamorlette, Hervé Germain, Ha Thi Hoang Nguyen, Anaïs F. M. Noisier, Gilles Ouvry
Publikováno v:
Tetrahedron Letters. 53:5380-5384
During our efforts to selectively synthesise N-arylated benzotriazole fragments, we developed a new primary aromatic amine protecting group strategy showing significant advantages over recognised protecting groups.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bd87d2b3eef1b937afaa67a4bade7b8
https://doi.org/10.1016/j.tetlet.2012.07.106
https://doi.org/10.1016/j.tetlet.2012.07.106