Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Anaïs F. Bardet"'
1
Akademický článek
E2F6 initiates stable epigenetic silencing of germline genes during embryonic development
Autor: Thomas Dahlet, Matthias Truss, Ute Frede, Hala Al Adhami, Anaïs F. Bardet, Michael Dumas, Judith Vallet, Johana Chicher, Philippe Hammann, Sarah Kottnik, Peter Hansen, Uschi Luz, Gonzalo Alvarez, Ghislain Auclair, Jochen Hecht, Peter N. Robinson, Christian Hagemeier, Michael Weber
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
DNA methylation targets CpG island promoters of germline genes to repress their expression in mouse somatic cells. Here the authors show that a transcription factor E2F6 is required to target CpG island DNA methylation and epigenetic silencing to ger
Externí odkaz: https://doaj.org/article/f118f417497a4386a18456d4d7889a0a
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2
Akademický článek
Genome-wide analysis in the mouse embryo reveals the importance of DNA methylation for transcription integrity
Autor: Thomas Dahlet, Andrea Argüeso Lleida, Hala Al Adhami, Michael Dumas, Ambre Bender, Richard P. Ngondo, Manon Tanguy, Judith Vallet, Ghislain Auclair, Anaïs F. Bardet, Michael Weber
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
DNA methyltrasferases play important role during mouse embryo development. Here the authors reveal the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the methylome and transcriptome of mouse embryos genome-wide.
Externí odkaz: https://doaj.org/article/590f66de9a5641b6a92e0860825a1341
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3
Data from Loss of Apc Rapidly Impairs DNA Methylation Programs and Cell Fate Decisions in Lgr5+ Intestinal Stem Cells
Autor: Philippe Jay, François Gerbe, Michael Weber, Pierre Cesses, Stanislas Quesada, Thomas Kergrohen, Anaïs F. Bardet, Michael Dumas, Alicia Giordano, Elouan Cleroux, Laure Garnier, Marco Bruschi
Colorectal cancer initiation and progression result from the accumulation of genetic and epigenetic alterations. Although aberrant gene expression and DNA methylation profiles are considered hallmarks of colorectal cancer development, the precise tim
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd375643ec1eb848857b33343fb7b54b
https://doi.org/10.1158/0008-5472.c.6511593.v1
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9
Focal DNA hypo-methylation in cancer is mediated by transcription factors binding
Autor: Michael Weber, Dylane Detilleux, Anaïs F. Bardet, Delphine Balaramane, Yannick G. Spill
Aberrant DNA methylation has emerged as a hallmark of cancer cells and profiling their epigenetic landscape has widely been carried out in many types of cancer. However, the mechanisms underlying changes in DNA methylation remain elusive. Transcripti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930bd9129ee42205b3fe870953fb0b21
https://hal.archives-ouvertes.fr/hal-03380298/document
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10
The BTB-domain transcription factor ZBTB2 recruits chromatin remodelers and a histone chaperone during the exit from pluripotency
Autor: Anaïs F. Bardet, Daniel Hess, Daniel Olivieri, Sébastien A. Smallwood, Ulrich Elling, Sujani Paramanathan, Joerg Betschinger
Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2021, 297 (2), pp.100947. ⟨10.1016/j.jbc.2021.100947⟩
The Journal of Biological Chemistry
Transcription factors (TFs) harboring broad-complex, tramtrack, and bric-a-brac (BTB) domains play important roles in development and disease. These BTB domains are thought to recruit transcriptional modulators to target DNA regions. However, a syste
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::026739c7c937a26878c6cad73fcd7ad9
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