Výsledky vyhledávání - "Ana, Zarubica"

Akademický článek

Intranasal Multiepitope PD‐L1‐siRNA‐Based Nanovaccine: The Next‐Gen COVID‐19 Immunotherapy

Publikováno v: Advanced Science, Vol 11, Iss 40, Pp n/a-n/a (2024)

Abstract The first approved vaccines for human use against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) are nanotechnology‐based. Although they are modular, rapidly produced, and can reduce disease severity, the currently availa

Externí odkaz: https://doaj.org/article/b5734eacdf3b49c7be9c99d042cb5913

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Akademický článek

Anti-HVEM mAb therapy improves antitumoral immunity both in vitro and in vivo, in a novel transgenic mouse model expressing human HVEM and BTLA molecules challenged with HVEM expressing tumors

Autor: Fabrice Barlesi, Laurent Gorvel, Daniel Olive, Clemence Demerle, Laurent Greillier, Sonia Pastor, Geoffrey Guittard, Jacques A Nunes, Marielle Mello, Clara Degos, Ana Zarubica, Fabien Angelis, Frédéric Fiore, Bernard Malissen, Hervé Luche

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)

Background Tumor necrosis factor superfamily member 14 (TNFRSF14)/herpes virus entry mediator (HVEM) is the ligand for B and T lymphocyte attenuator (BTLA) and CD160-negative immune co-signaling molecules as well as viral proteins. Its expression is

Externí odkaz: https://doaj.org/article/fdfc15c4c1eb4b6cb203ba727e691a4f

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Akademický článek

Design, immunogenicity, and efficacy of a pan-sarbecovirus dendritic-cell targeting vaccine

Publikováno v: EBioMedicine, Vol 80, Iss , Pp 104062- (2022)

Summary: Background: There is an urgent need of a new generation of vaccine that are able to enhance protection against SARS-CoV-2 and related variants of concern (VOC) and emerging coronaviruses. Methods: We identified conserved T- and B-cell epitop

Externí odkaz: https://doaj.org/article/7c4c51eefde4479983b08dc65c09880e

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Akademický článek

Control of CDH1/E-Cadherin Gene Expression and Release of a Soluble Form of E-Cadherin in SARS-CoV-2 Infected Caco-2 Intestinal Cells: Physiopathological Consequences for the Intestinal Forms of COVID-19

Autor: Ikram Omar Osman, Clémence Garrec, Gabriel Augusto Pires de Souza, Ana Zarubica, Djamal Brahim Belhaouari, Jean-Pierre Baudoin, Hubert Lepidi, Jean-Louis Mege, Bernard Malissen, Bernard La Scola, Christian Albert Devaux

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

COVID-19 is the biggest pandemic the world has seen this century. Alongside the respiratory damage observed in patients with severe forms of the disease, gastrointestinal symptoms have been frequently reported. These symptoms (e.g., diarrhoea), somet

Externí odkaz: https://doaj.org/article/a790b63766cd4538b86c26549695a32a

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nanoCLAMP potently neutralizes SARS-CoV-2 and protects K18-hACE2 mice from infection

Autor: Quentin Pagneux, Nathalie Garnier, Manon Fabregue, Sarah Sharkaoui, Sophie Mazzoli, Ilka Engelmann, Rabah Boukherroub, Mary Strecker, Eric Cruz, Peter Ducos, Ana Zarubica, Richard Suderman, Sabine Szunerits

Intranasal treatments, combined with vaccination, has the potential to slow mutational evolution of virusues by reducing transmission and replication. Here we illustrate the development of a SARS-CoV-2 receptor binding domain (RBD) nanoCLAMP and demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e8322c4924f0acc8ccc1249432ae6f49
https://doi.org/10.1101/2023.04.03.535401

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Meningeal macrophages protect against viral neuroinfection

Publikováno v: Immunity
Immunity, 2022, 55 (11), pp.2103-2117.e10. ⟨10.1016/j.immuni.2022.10.005⟩

The surface of the central nervous system (CNS) is protected by the meninges, which contain a dense network of meningeal macrophages (MMs). Here, we examined the role of tissue-resident MM in viral infection. MHC-II� MM were abundant neonatally, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e57479ff5ad5e4b3e18439fe6d2c390

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Akademický článek

Genetic, structural, and chemical insights into the dual function of GRASP55 in germ cell Golgi remodeling and JAM-C polarized localization during spermatogenesis.

Publikováno v: PLoS Genetics, Vol 13, Iss 6, p e1006803 (2017)

Spermatogenesis is a dynamic process that is regulated by adhesive interactions between germ and Sertoli cells. Germ cells express the Junctional Adhesion Molecule-C (JAM-C, encoded by Jam3), which localizes to germ/Sertoli cell contacts. JAM-C is in

Externí odkaz: https://doaj.org/article/bedb603c57514fa283b9ee3eebe39a42

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Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism

Autor: Claude, Gregoire, Lionel, Spinelli, Sergio, Villazala-Merino, Laurine, Gil, María Pía, Holgado, Myriam, Moussa, Chuang, Dong, Ana, Zarubica, Mathieu, Fallet, Jean-Marc, Navarro, Bernard, Malissen, Pierre, Milpied, Mauro, Gaya

Publikováno v: Immunity
Immunity, 2022, 55 (7), pp.1216-1233.e9. ⟨10.1016/j.immuni.2022.06.002⟩

International audience; Lung-resident memory B cells (MBCs) provide localized protection against reinfection in respiratory airways. Currently, the biology of these cells remains largely unexplored. Here, we combined influenza and SARS-CoV-2 infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b59cd3f16323cc9af145346ae65bdc
https://amu.hal.science/hal-03754448/file/main.pdf

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