Zobrazeno 1 - 10
of 718
pro vyhledávání: '"An Zwijsen"'
Autor:
Annemarie Lang, Andreas Benn, Joseph M. Collins, Angelique Wolter, Tim Balcaen, Greet Kerckhofs, An Zwijsen, Joel D. Boerckel
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Skeletal development depends on coordinated angiogenesis and osteogenesis. Bone morphogenetic proteins direct bone formation in part by activating SMAD1/5 signaling in osteoblasts. However, the role of SMAD1/5 in skeletal endothelium is unkn
Externí odkaz:
https://doaj.org/article/3c3f2b0dd6834e6782d3048a6c987169
Autor:
Paraskevi Athanasouli, Martina Balli, Anchel De Jaime-Soguero, Annekatrien Boel, Sofia Papanikolaou, Bernard K. van der Veer, Adrian Janiszewski, Tijs Vanhessche, Annick Francis, Youssef El Laithy, Antonio Lo Nigro, Francesco Aulicino, Kian Peng Koh, Vincent Pasque, Maria Pia Cosma, Catherine Verfaillie, An Zwijsen, Björn Heindryckx, Christoforos Nikolaou, Frederic Lluis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Signal transduction and gene expression regulation via downstream transcription factors shape the early mammalian embryo. Here the authors show that Wnt/TCF7L1 transcriptional repressive activity is required for primitive endoderm lineage formation.
Externí odkaz:
https://doaj.org/article/8c6090935fbd461d86225955994338e9
Autor:
Anne Richter, Marta S. Alexdottir, Svala H. Magnus, Tobias R. Richter, Masato Morikawa, An Zwijsen, Gudrun Valdimarsdottir
Publikováno v:
Stem Cell Reports, Vol 12, Iss 6, Pp 1250-1259 (2019)
Summary: Human embryonic stem cells (hESCs) are instrumental in characterizing the molecular mechanisms of human vascular development and disease. Bone morphogenetic proteins (BMPs) play a pivotal role in cardiovascular development in mice, but their
Externí odkaz:
https://doaj.org/article/d2bef0f2130446c89eb721a8f8303d73
Autor:
Paul P. Van Veldhoven, Evelyn de Schryver, Stephen G. Young, An Zwijsen, Marc Fransen, Marc Espeel, Myriam Baes, Elke Van Ael
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Mice lacking PMP34, a peroxisomal membrane transporter encoded by Slc25a17, did not manifest any obvious phenotype on a Swiss Webster genetic background, even with various treatments designed to unmask impaired peroxisomal functioning. Peroxisomal α
Externí odkaz:
https://doaj.org/article/afa6d177a3c94b11a5bd0eb0d5bb4c51
Autor:
Annelies Nonneman, Nathan Criem, Sebastian A. Lewandowski, Rik Nuyts, Dietmar R. Thal, Frank W. Pfrieger, John Ravits, Philip Van Damme, An Zwijsen, Ludo Van Den Bosch, Wim Robberecht
Publikováno v:
Neurobiology of Disease, Vol 119, Iss , Pp 26-40 (2018)
Amyotrophic lateral sclerosis (ALS) is a late-onset devastating degenerative disease mainly affecting motor neurons. Motor neuron degeneration is accompanied and aggravated by oligodendroglial pathology and the presence of reactive astrocytes and mic
Externí odkaz:
https://doaj.org/article/540696d1c29544e4af2c75d91b8a269f
Autor:
Antonio Lo Nigro, Anchel de Jaime-Soguero, Rita Khoueiry, Dong Seong Cho, Giorgia Maria Ferlazzo, Ilaria Perini, Vanesa Abon Escalona, Xabier Lopez Aranguren, Susana M. Chuva de Sousa Lopes, Kian Peng Koh, Pier Giulio Conaldi, Wei-Shou Hu, An Zwijsen, Frederic Lluis, Catherine M. Verfaillie
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 318-333 (2017)
In early mouse pre-implantation development, primitive endoderm (PrE) precursors are platelet-derived growth factor receptor alpha (PDGFRα) positive. Here, we demonstrated that cultured mouse embryonic stem cells (mESCs) express PDGFRα heterogeneou
Externí odkaz:
https://doaj.org/article/aa9c6edd25094bb88a2946552f3a39cd
Autor:
Maria Gomes Fernandes, Ruben Dries, Matthias S. Roost, Stefan Semrau, Ana de Melo Bernardo, Richard P. Davis, Ramprasad Ramakrishnan, Karoly Szuhai, Elke Maas, Lieve Umans, Vanesa Abon Escalona, Daniela Salvatori, Dieter Deforce, Wim Van Criekinge, Danny Huylebroeck, Christine Mummery, An Zwijsen, Susana M. Chuva de Sousa Lopes
Publikováno v:
Stem Cell Reports, Vol 6, Iss 1, Pp 85-94 (2016)
Naive mouse embryonic stem cells (mESCs) are in a metastable state and fluctuate between inner cell mass- and epiblast-like phenotypes. Here, we show transient activation of the BMP-SMAD signaling pathway in mESCs containing a BMP-SMAD responsive rep
Externí odkaz:
https://doaj.org/article/b277eb09b8a7405197a999545a52fb37
Publikováno v:
Biomolecules, Vol 10, Iss 3, p 488 (2020)
Vascular development is an orchestrated process of vessel formation from pre-existing vessels via sprouting and intussusceptive angiogenesis as well as vascular remodeling to generate the mature vasculature. Bone morphogenetic protein (BMP) signaling
Externí odkaz:
https://doaj.org/article/02142a5b56e94959a5838b06ba20e6b4
Autor:
Karen Vrijens, Sofie Thys, Marcel T. De Jeu, Andrei A. Postnov, Markus Pfister, Luk Cox, An Zwijsen, Viviane Van Hoof, Marcus Mueller, Nora M. De Clerck, Chris I. De Zeeuw, Guy Van Camp, Lut Van Laer
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 1, Pp 28-40 (2006)
The mouse mutant Ozzy, originating from an ENU-mutagenesis programme, displays a head bobbing phenotype. We report here that Ozzy mice show a clear deficit in vestibulo-ocular reflex (VOR). Micro-CT scanning of the inner ears showed narrowing and tru
Externí odkaz:
https://doaj.org/article/caa5459afa6040feb0f3a7f34531a27b
Publikováno v:
In Nuclear Engineering and Design October 2024 427