Zobrazeno 1 - 10
of 57 236
pro vyhledávání: '"An Vermeulen"'
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 5, Pp 729-742 (2024)
Abstract The objective of this study was to compare the efficacy of short interfering RNA therapeutics (siRNAs) in reducing hepatitis B surface antigen (HBsAg) levels in hepatitis B‐infected (HBV) mice across multiple siRNA therapeutic classes usin
Externí odkaz:
https://doaj.org/article/78b48eb32ca046f181edd25aae46f3c5
Autor:
Orphélie Lootens, Marthe De Boevre, Elke Gasthuys, Sarah De Saeger, Jan Van Bocxlaer, An Vermeulen
Publikováno v:
Toxins, Vol 16, Iss 6, p 259 (2024)
Physiologically based pharmacokinetic (PBPK) models were utilized to investigate potential interactions between aflatoxin B1 (AFB1) and efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor drug and inducer of several CYP enzymes, includi
Externí odkaz:
https://doaj.org/article/925c5c88ab5c4a01bc28e9ef8cf963d5
Autor:
Jocelyn H. Leu, An Vermeulen, Claudia Abbes, Santiago Arroyo, William S. Denney, Leona E. Ling
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
IntroductionNipocalimab is a high-affinity, fully human, aglycosylated, effectorless, immunoglobulin G (IgG) 1 monoclonal antibody that targets the neonatal Fc receptor (FcRn), decreases systemic IgG including autoantibodies, and is under development
Externí odkaz:
https://doaj.org/article/b0db3a96072d4cefb2aece1ceaf0708f
Acute balenine supplementation in humans as a natural carnosinase-resistant alternative to carnosine
Autor:
Sarah de Jager, An Vermeulen, Siegrid De Baere, Thibaux Van der Stede, Eline Lievens, Siska Croubels, Ralf Jäger, Martin Purpura, Jan G. Bourgois, Wim Derave
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Balenine possesses some of carnosine’s and anserine’s functions, yet it appears more resistant to the hydrolysing CN1 enzyme. The aim of this study was to elucidate the stability of balenine in the systemic circulation and its bioavailab
Externí odkaz:
https://doaj.org/article/c185e2c4472d4b42ad8909604368d772
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 53 (2023)
To date, food–drug interactions in the pediatric population remain understudied. The current food effect studies are mostly performed in adults and do not mimic the real-life situation in the pediatric population. Since the potential benefits of fo
Externí odkaz:
https://doaj.org/article/8c1714c7846f401e976b48f064323f90
Autor:
Pieter‐Jan De Sutter, Maxime Van Haeverbeke, Eva Van Braeckel, Stephanie Van Biervliet, Jan Van Bocxlaer, An Vermeulen, Elke Gasthuys
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 8, Pp 951-966 (2022)
Abstract Cystic fibrosis (CF) has been linked to altered drug disposition in various studies. However, the magnitude of these changes, influencing factors, and underlying mechanisms remain a matter of debate. The primary aim of this work was therefor
Externí odkaz:
https://doaj.org/article/8274e782a92e4d6d81b86237fa6c5c12
Publikováno v:
Pharmaceutics, Vol 15, Iss 9, p 2348 (2023)
The volume of distribution at steady state (Vss) in neonates is still often estimated through isometric scaling from adult values, disregarding developmental changes beyond body weight. This study aimed to compare the accuracy of two physiologically
Externí odkaz:
https://doaj.org/article/3287cb894b1b47cf9172ee031c0510b4
Autor:
Samya Van Coillie, Emily Van San, Ines Goetschalckx, Bartosz Wiernicki, Banibrata Mukhopadhyay, Wulf Tonnus, Sze Men Choi, Ria Roelandt, Catalina Dumitrascu, Ludwig Lamberts, Geert Dams, Wannes Weyts, Jelle Huysentruyt, Behrouz Hassannia, Irina Ingold, Suhas Lele, Evelyne Meyer, Maya Berg, Ruth Seurinck, Yvan Saeys, An Vermeulen, Alexander L. N. van Nuijs, Marcus Conrad, Andreas Linkermann, Mohan Rajapurkar, Peter Vandenabeele, Eric Hoste, Koen Augustyns, Tom Vanden Berghe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Catalytic iron is associated with intensive care unit mortality and is known to cause free radical-mediated cellular toxicity. Here the authors show that a soluble ferrostatin-analogue (a ferroptosis inhibitor) protects mice from injury and death in
Externí odkaz:
https://doaj.org/article/a4909380e98741e3bf0ff690fb71d483
Autor:
Bakos, Evelin, Boterenbrood, Henk, Dönszelmann, Mark, Egli, Florian, Franco, Luca, Gottardo, Carlo A., Habraken, René, König, Adriaan, Pellegrino, Antonio, Valderanis, Chrysostomos, Vermeulen, Jos, Wijnen, Thei, Wu, Mengqing
The ATLAS Muon Drift Tube (MDT) ReadOut Drivers (MROD), 204 VME modules that are an essential part of the readout chain of the 1,150 MDT chambers, have been in operation for more than 15 years and are expected to remain in operation until about 2026.
Externí odkaz:
http://arxiv.org/abs/2411.07709
Autor:
Moradian, Jordan, Dubrovsky, Michael, Sama, Megha, Korecky, Pavel, Kulkarni, Sidarth, Goder, Yaniv, Vermeulen, Diedrik
In a study of 107 male Y Combinator founders, a surprising correlation between age-normalized testosterone and company stage was uncovered. Testosterone, a hormone associated with confidence, dominance, and drive, increased by 55.7% from pre-seed to
Externí odkaz:
http://arxiv.org/abs/2411.03361