Zobrazeno 1 - 10
of 5 107
pro vyhledávání: '"An‐Yuan Guo"'
Publikováno v:
Chinese Medical Journal, Vol 137, Iss 17, Pp 2052-2064 (2024)
Abstract. Tumor bioinformatics plays an important role in cancer research and precision medicine. The primary focus of traditional cancer research has been molecular and clinical studies of a number of fundamental pathways and genes. In recent years,
Externí odkaz:
https://doaj.org/article/1a5f7e941e5d478ea796745050394158
Autor:
Jing‐Min Yang, Nan Zhang, Tao Luo, Mei Yang, Wen‐Kang Shen, Zhen‐Lin Tan, Yun Xia, Libin Zhang, Xiaobo Zhou, Qian Lei, An‐Yuan Guo
Publikováno v:
iMeta, Vol 3, Iss 5, Pp n/a-n/a (2024)
Abstract T cell is an indispensable component of the immune system and its multifaceted functions are shaped by the distinct T cell types and their various states. Although multiple computational models exist for predicting the abundance of diverse T
Externí odkaz:
https://doaj.org/article/d694672db6da46bea35852611753e14c
Autor:
Hui Hu, Ling Tang, Yuyan Zhao, Jiali Cheng, Mei Huang, Yong You, Ping Zou, Qian Lei, Xiaojian Zhu, An-Yuan Guo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 2, Pp 102225- (2024)
Chimeric antigen receptor T (CAR-T) cell therapy targeting T cell tumors still faces many challenges, one of which is its fratricide due to the target gene expressed on CAR-T cells. Despite this, these CAR-T cells can be expanded in vitro by extendin
Externí odkaz:
https://doaj.org/article/e919e6508dbb44ad83fb3b1840cbd631
Publikováno v:
Small Structures, Vol 4, Iss 9, Pp n/a-n/a (2023)
Extracellular vesicles (EVs) play crucial role in mediating intercellular communication. Small RNA is an important component in EVs. However, the proportion of small RNA sequencing (smRNA‐seq) reads in EVs mapped to the human genome is much lower t
Externí odkaz:
https://doaj.org/article/48af179220444e37a63ee0c9814f3c32
Autor:
Mei Luo, Lin Ye, Ruimin Chang, Youqiong Ye, Zhao Zhang, Chunjie Liu, Shengli Li, Ying Jing, Hang Ruan, Guanxiong Zhang, Yi He, Yaoming Liu, Yu Xue, Xiang Chen, An-Yuan Guo, Hong Liu, Leng Han
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Autophagy has been typically associated with resistance to cancer therapy, and autophagy inhibitors have been explored in cancer. Here, the authors investigate autophagy signatures and their association with drug response in cancer, and find that aut
Externí odkaz:
https://doaj.org/article/0785129e6d9c4a64a24ec18c67a2271f
Autor:
Fei-Fei Hu, Hao Chen, Yang Duan, Bei Lan, Chun-Jie Liu, Hui Hu, Xu Dong, Qiong Zhang, Yi-Ming Cheng, Min Liu, An-Yuan Guo, Chenghao Xuan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 670-684 (2022)
The disruption of epigenetic regulation is common in tumors; the abnormal expression of epigenetic factors leads to cancer occurrence and development. In this study, to investigate the potential function of histone methylation regulators in lung aden
Externí odkaz:
https://doaj.org/article/90c6575aeb244a54bd5fd9df7303694b
Autor:
Chen Dong, Ya‐ru Miao, Rui Zhao, Mei Yang, An‐yuan Guo, Zhong‐hui Xue, Teng Li, Qiong Zhang, Yanfeng Bao, Chen Shen, Chi Sun, Ying Yang, Xi‐xi Gu, Yi Jin, Rong Li, Min Xu, Jia‐xin Guo, Zhi‐ying Zong, Wei Zhou, Mei He, Dan‐ni Wang, Jian‐you Su, Xiao‐ming Zhang, Xu‐hui Zeng, Jian‐lin Gao, Zhi‐feng Gu
Publikováno v:
Advanced Science, Vol 9, Iss 36, Pp n/a-n/a (2022)
Abstract Centenarians, who show mild infections and low incidence of tumors, are the optimal model to investigate healthy aging. However, longevity related immune characteristics has not been fully revealed largely due to lack of appropriate controls
Externí odkaz:
https://doaj.org/article/92a306777f614196a2cc3df9cb5d91a4
Decays $B\to DP\ell^+\nu_\ell~(\ell=e,\mu,\tau)$ with the non-resonance, the charmed vector resonances, the charmed scalar resonances and the charmed tensor resonances are calculated by using the SU(3) flavor symmetry. Firstly, the decay amplitudes o
Externí odkaz:
http://arxiv.org/abs/2407.00372
hTFtarget: A Comprehensive Database for Regulations of Human Transcription Factors and Their Targets
Publikováno v:
Genomics, Proteomics & Bioinformatics, Vol 18, Iss 2, Pp 120-128 (2020)
Transcription factors (TFs) as key regulators play crucial roles in biological processes. The identification of TF–target regulatory relationships is a key step for revealing functions of TFs and their regulations on gene expression. The accumulate
Externí odkaz:
https://doaj.org/article/a12aa05604ce41759bbcbcfdb9dd1ef1
Autor:
Sheng-Yan Lin, Fei-Fei Hu, Ya-Ru Miao, Hui Hu, Qian Lei, Qiong Zhang, Qiubai Li, Hongxiang Wang, Zhichao Chen, An-Yuan Guo
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 476-484 (2019)
Cytogenetically normal acute myeloid leukemia (CN-AML) presents with diverse outcomes in different patients and is categorized as an intermediate prognosis group. It is important to identify prognostic factors for CN-AML risk stratification. In this
Externí odkaz:
https://doaj.org/article/e2f19097803d4c2ba0f5ab60cad23fe5