Zobrazeno 1 - 10
of 3 896
pro vyhledávání: '"Amyotrophic lateral sclerosis (ALS)"'
Autor:
Ilaria Martinelli, Jessica Mandrioli, Andrea Ghezzi, Elisabetta Zucchi, Giulia Gianferrari, Cecilia Simonini, Francesco Cavallieri, Franco Valzania
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 1, Pp 130-138 (2025)
Amyotrophic lateral sclerosis (ALS) is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex, brainstem, and spinal cord. While the typical clinical phenotype of ALS involves both upper and lower motor n
Externí odkaz:
https://doaj.org/article/0208827a07b44cb9bfdaaf5a41d406a3
Autor:
Cinzia Femiano, Antonio Bruno, Luana Gilio, Fabio Buttari, Ettore Dolcetti, Giovanni Galifi, Federica Azzolini, Angela Borrelli, Roberto Furlan, Annamaria Finardi, Alessandra Musella, Georgia Mandolesi, Marianna Storto, Diego Centonze, Mario Stampanoni Bassi
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Experimental studies identified a role of neuroinflammation in the pathogenesis of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). However, the role of inflammatory molecules as diagnostic and prognostic biomarkers
Externí odkaz:
https://doaj.org/article/1f57bd670cb64b908210235a78a09890
Autor:
Jill Carlton, Philip Powell, Donna Rowen, Claire Williams, Alys Wyn Griffiths, Esther Hobson, Christopher McDermott
Publikováno v:
Health and Quality of Life Outcomes, Vol 22, Iss 1, Pp 1-8 (2024)
Abstract Background Patient reported outcome measures (PROMs) can be used to assess the impact of health conditions upon an individual’s health-related quality of life (HRQoL). Whilst PROMs have been used to quantify the HRQoL impact of amyotrophic
Externí odkaz:
https://doaj.org/article/9f70e66277aa471cb2bfc1d74b204488
Publikováno v:
BMC Palliative Care, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motoneuron. It is associated with a life expectancy of 2–4 years after diagnosis. Individuals experience paralysis, dysphagia, respiratory
Externí odkaz:
https://doaj.org/article/9851dd722de5457f82e0988b581c78ff
Autor:
Chris Kato, Koji Ueda, Satoru Morimoto, Shinichi Takahashi, Shiho Nakamura, Fumiko Ozawa, Daisuke Ito, Yugaku Daté, Kensuke Okada, Naoki Kobayashi, Jin Nakahara, Hideyuki Okano
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-18 (2024)
Abstract Background Extracellular vesicles (EVs) hold the potential for elucidating the pathogenesis of amyotrophic lateral sclerosis (ALS) and serve as biomarkers. Notably, the comparative and longitudinal alterations in the protein profiles of EVs
Externí odkaz:
https://doaj.org/article/166542d458c04fcaa788a27b67f26db5
Autor:
Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W. Cleveland, James Shorter, Sandrine Da Cruz
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract RNA binding proteins have emerged as central players in the mechanisms of many neurodegenerative diseases. In particular, a proteinopathy of fused in sarcoma (FUS) is present in some instances of familial Amyotrophic lateral sclerosis (ALS)
Externí odkaz:
https://doaj.org/article/95638d30dda343ee9bedd62a7544c554
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-4 (2024)
Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that affects the motor neuron. One aspect of the neuropathology involved in ALS includes increased genomic damage and impaired DNA repair capability. The TAR-DNA bindin
Externí odkaz:
https://doaj.org/article/789bc818a5f940d18d10982b7e5cbe39
Autor:
Shylesh Bhaskaran, Katarzyna M. Piekarz, Jacob Brown, Brian Yang, Sarah R. Ocañas, Jonathan D. Wren, Constantin Georgescu, Christopher Bottoms, Ashley Murphy, Jessica Thomason, Debra Saunders, Nataliya Smith, Rheal Towner, Holly Van Remmen
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
Our study investigated the therapeutic potential of OKN-007 in the SOD1 G93A mouse model of amyotrophic lateral sclerosis (ALS). The impact of OKN-007, known for its antioxidant, anti-inflammatory, and neuroprotective properties, was tested at two do
Externí odkaz:
https://doaj.org/article/0e640ce65630411f9790072628df78b8