Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease

Autor: Yu Li, Ji Geng, Su Guo, Sungun Huh, Ishaq Tantray, William W. Seeley, Salvatore Spina, Charles G. Glabe, Suman Rimal, Rasika Vartak, Bingwei Lu, Shuangxi Li, Lea T. Grinberg, Hannes Vogel

Publikováno v: Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-24 (2021)
Acta Neuropathologica Communications
Acta neuropathologica communications, vol 9, iss 1

Amyloid precursor protein (APP) metabolism is central to Alzheimer’s disease (AD) pathogenesis, but the key etiological driver remains elusive. Recent failures of clinical trials targeting amyloid-β (Aβ) peptides, the proteolytic fragments of amy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4adb0b05e00102ec0e4f29fee7832c1
https://doaj.org/article/5d9461b781734fd380831ae6cd0fc299

Divalent cation tolerance protein binds to β-secretase and inhibits the processing of amyloid precursor protein

Autor: Runzhong, Liu, Haibo, Hou, Xuelian, Yi, Shanwen, Wu, Huan, Zeng

Publikováno v: Neural Regeneration Research

The deposition of amyloid-beta is a pathological hallmark of Alzheimer's disease. Amyloid-beta is derived from amyloid precursor protein through sequential proteolytic cleavages by β-secretase (beta-site amyloid precursor protein-cleaving enzyme 1)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::01c487a47430275286b18aad3e4c15c6
https://pubmed.ncbi.nlm.nih.gov/25206392

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