The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer’s disease

Autor: Alessandra Piersigilli, Sebastien Mosser, Michael Stumpe, Hermeto Gerber, Christine Goepfert, Joern Dengjel, Patrick C. Fraering, Benjamin Boury-Jamot, Urs Albrecht, Fulvio Magara

Publikováno v: Acta Neuropathologica Communications
Gerber, Hermeto; Mosser, Sebastien; Boury-Jamot, Benjamin; Stumpe, Michael; Piersigilli, Alessandra; Göpfert, Christine; Dengjel, Joern; Albrecht, Urs; Magara, Fulvio; Fraering, Patrick C (2019). The APMAP interactome reveals new modulators of APP processing and beta-amyloid production that are altered in Alzheimer's disease. Acta neuropathologica communications, 7(1), p. 13. BioMed Central 10.1186/s40478-019-0660-3
Acta neuropathologica communications, vol. 7, no. 1, pp. 13
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)

The adipocyte plasma membrane-associated protein APMAP is expressed in the brain where it associates with γ-secretase, a protease responsible for the generation of the amyloid-β peptides (Aβ) implicated in the pathogenesis of Alzheimer’s disease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3270b0c727c5a10eb681ff5074ebc89a
http://europepmc.org/articles/PMC6354426

Amyloid Precursor-Like Protein 2 deletion-induced retinal synaptopathy related to congenital stationary night blindness: structural, functional and molecular characteristics

Autor: Marc Abitbol, Virginie Dinet, Roberto Cappai, Yvan Arsenijevic, Na An, Francine Behar-Cohen, Mohamed El Sanharawi, Giuseppe D. Ciccotosto, Laurent Jonet, Frédéric Mascarelli, Céline Borras, Michèle Savoldelli, Kimberley Delaunay, Corinne Kostic, Caroline Pirou, Isabelle Ranchon-Cole

Publikováno v: Molecular Brain
Molecular Brain, 2015, 9 (1), pp.64. ⟨10.1186/s13041-016-0245-z⟩
Molecular Brain, BioMed Central, 2016, <10.1186/s13041-016-0245-z>
Molecular Brain, 2015, 9 (1), pp.64. 〈10.1186/s13041-016-0245-z〉
Molecular brain, vol. 9, no. 1, pp. 64

Background Amyloid precursor protein knockout mice (APP-KO) have impaired differentiation of amacrine and horizontal cells. APP is part of a gene family and its paralogue amyloid precursor-like protein 2 (APLP2) has both shared as well as distinct ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8d3b103ccec29f39ebca104230e8144
https://pubmed.ncbi.nlm.nih.gov/27267879

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

Autor: Jean Huang, Paul M. Mathews, Gang Yu, Peter St George-Hyslop, Stephen D. Schmidt, Jennifer Liauw, You-Qiang Song, Howard T.J. Mount, Ralph A. Nixon, Catherine Bergeron, David Westaway, Serap Erdebil, Hiroshe Hasegawa, Fusheng Chen, Richard Rozmahel, Yongjun Gu, Paul E. Fraser, Van Nguyen

Publikováno v: Proceedings of the National Academy of Sciences. 99:14452-14457

Presenilin 1 (PS1), presenilin 2, and nicastrin form high molecular weight complexes that are necessary for the endoproteolysis of several type 1 transmembrane proteins, including amyloid precursor protein (APP) and the Notch receptor, by apparently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e6f72016783d71c002cbe89d2b45acd
https://doi.org/10.1073/pnas.222413999

Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system

Autor: Toshiharu Suzuki, Takeshi Ikeuchi, Hiroyasu Akatsu, Tomoko Konno, Takayuki Yamamoto, Saori Hata, Yukiko Hamada, Tohru Yamamoto, Masahiro Maeda, Tadashi Nakaya, Yuhki Saito, Yuko Horikoshi-Sakuraba, Sam Gandy

Publikováno v: Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 6, Iss 1, p 76 (2011)

Background Aggregatable amyloid β-peptide (Aβ) and non-aggregatable p3-Alcα are metabolic products of the γ-secretase cleavage of amyloid β-protein precursor (APP) and Alcadeinα (Alcα), respectively. Familial AD (FAD) -linked mutations in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05663c5dc56c5fa5c5f941e4c18302cc
https://pubmed.ncbi.nlm.nih.gov/22067061

A key role for the microglial NADPH oxidase in APP-dependent killing of neurons

Autor: Karl-Heinz Krause, Bin Qin, Lena Serrander, Bin Li, Laetitia Cartier, Michel Dubois-Dauphin

Publikováno v: Neurobiology of Aging, Vol. 27, No 11 (2006) pp. 1577-1587

Reactive oxygen species (ROS) and deposition of cleaved products of amyloid precursor protein (APP) are thought to contribute to neuronal loss observed in Alzheimer's disease (AD). The relationship between these factors was studied in a neuroblastoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ac8315dd56538d066950aa49025c5b
https://pubmed.ncbi.nlm.nih.gov/16260066