Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Amyloid beta-Peptides / metabolism"'
Autor:
Vargas-Soria, Maria, Ramos-Rodriguez, Juan Jose, del Marco, Angel, Hierro-Bujalance, Carmen, Carranza-Naval, Maria Jose, Calvo-Rodriguez, Maria, van Veluw, Susanne J., Stitt, Alan W., Simó Canonge, Rafael, Bacskai, Brian J., Infante-Garcia, Carmen, Garcia-Alloza, Monica, Universitat Autònoma de Barcelona
Publikováno v:
Scientia
Vargas-Soria, M, Ramos-Rodriguez, J J, Del Marco, A, Hierro-Bujalance, C, Carranza-Naval, M J, Calvo-Rodriguez, M, Veluw, S J V, Stitt, A W, Simó, R, Bacskai, B J, Infante-Garcia, C & Garcia-Alloza, M 2022, ' Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer's disease and type two diabetes ', Fluids and Barriers of the CNS, vol. 19, 88 . https://doi.org/10.1186/s12987-022-00380-6
Vargas-Soria, M, Ramos-Rodriguez, J J, Del Marco, A, Hierro-Bujalance, C, Carranza-Naval, M J, Calvo-Rodriguez, M, Veluw, S J V, Stitt, A W, Simó, R, Bacskai, B J, Infante-Garcia, C & Garcia-Alloza, M 2022, ' Accelerated amyloid angiopathy and related vascular alterations in a mixed murine model of Alzheimer's disease and type two diabetes ', Fluids and Barriers of the CNS, vol. 19, 88 . https://doi.org/10.1186/s12987-022-00380-6
Background: While aging is the main risk factor for Alzheimer´s disease (AD), emerging evidence suggests that metabolic alterations such as type 2 diabetes (T2D) are also major contributors. Indeed, several studies have described a close relationshi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27dff62dae6c6c93aec488b267ce1a7e
https://hdl.handle.net/10481/78314
https://hdl.handle.net/10481/78314
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific reports, Vol. 11, No 1 (2021) P. 19412
Scientific Reports
Scientific reports, Vol. 11, No 1 (2021) P. 19412
Alzheimer’s disease (AD) is characterized by amyloid (Aβ) protein aggregation and neurofibrillary tangles accumulation, accompanied by neuroinflammation. With all the therapeutic attempts targeting these biomarkers having been unsuccessful, the un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f2ec98232d859e6506cec0b1c4790a
https://doaj.org/article/1fd7e2b173d64bf296cc67fcccdb9cd1
https://doaj.org/article/1fd7e2b173d64bf296cc67fcccdb9cd1
Publikováno v:
Cells; Volume 11; Issue 14; Pages: 2223
Neuroinflammation is one of the core pathological features of Alzheimer’s disease (AD) as both amyloid β (Aβ) and tau monomers and oligomers can trigger the long-term pro-inflammatory phenotype of microglial cells with consequent overactivation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4248a500a8e5ce4faad212690d18ea81
https://urn.nsk.hr/urn:nbn:hr:105:515195
https://urn.nsk.hr/urn:nbn:hr:105:515195
Autor:
Ana Magalhães, Teresa Canedo, Renata L. Alves, Ana M. F. P. Silva, Sandra H. Vaz, Tiago Almeida, Renato Socodato, Cátia M. Silva, Ana M. Sebastião, João B. Relvas, António F. Ambrósio, Cord Brakebusch, Joana F. Henriques, Roberto Paes-de-Carvalho, Teresa Summavielle, Filipa I. Baptista, João P. Magalhães, Artur Rodrigues, Camila C. Portugal, Vanessa Coelho-Santos
Publikováno v:
Socodato, R, Portugal, C C, Canedo, T, Rodrigues, A, Almeida, T O, Henriques, J F, Vaz, S H, Magalhães, J, Silva, C M, Baptista, F I, Alves, R L, Coelho-Santos, V, Silva, A P, Paes-de-Carvalho, R, Magalhães, A, Brakebusch, C, Sebastião, A M, Summavielle, T, Ambrósio, A F & Relvas, J B 2020, ' Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration ', Cell Reports, vol. 31, no. 12, 107796, pp. 1-29 . https://doi.org/10.1016/j.celrep.2020.107796
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Cell Reports
© 2020 The Author(s). Creative Commons Attribution (CC BY 4.0)
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in
Nervous tissue homeostasis requires the regulation of microglia activity. Using conditional gene targeting in mice, we demonstrate that genetic ablation of the small GTPase Rhoa in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb571fceba1952acaecbe0bcbe6bc791
https://curis.ku.dk/portal/da/publications/microglia-dysfunction-caused-by-the-loss-of-rhoa-disrupts-neuronal-physiology-and-leads-to-neurodegeneration(af46c589-efa7-462d-8150-2a9c7d52e48a).html
https://curis.ku.dk/portal/da/publications/microglia-dysfunction-caused-by-the-loss-of-rhoa-disrupts-neuronal-physiology-and-leads-to-neurodegeneration(af46c589-efa7-462d-8150-2a9c7d52e48a).html
Autor:
Ellen Y. Cotrina, Mobina Alemi, Jordi Quintana, Abraham Martín, Jesús Jiménez-Barbero, Miguel Ángel Morcillo, Xabier Rios, Gregorio Valencia, Gemma Arsequell, Jordi Llop, Isabel Cardoso, Vanessa Gómez-Vallejo, Unai Cossío
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
It is well settled that the amyloidogenic properties of the plasma protein transporter transthyretin (TTR) can be modulated by compounds that stabilize its native tetrameric conformation. TTR is also present in cerebrospinal fluid where it can bind t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffcb361107d33deed686431ef962e303
http://hdl.handle.net/10261/200655
http://hdl.handle.net/10261/200655
Autor:
Bernard L. Schneider, Patrick Aebischer, Vanessa Laversenne, Marco Stampanoni, Erhard Kopetzki, Helmut Jacobsen, Alberto Astolfo, Bernd Bohrmann, Aurélien Lathuilière
Publikováno v:
Brain, Vol. 139, No Pt 5 (2016) pp. 1587-1604
Passive immunization against misfolded toxic proteins is a promising approach to treat neurodegenerative disorders. For effective immunotherapy against Alzheimer's disease, recent clinical data indicate that monoclonal antibodies directed against the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e55d820f599d1a63a446b342848a73
https://archive-ouverte.unige.ch/unige:155885
https://archive-ouverte.unige.ch/unige:155885
Autor:
Vasanthy Narayanaswami, Vincent Raussens, Shiori Tamamizu-Kato, Erik Goormaghtigh, Yves F. Dufrêne, Rabia Sarroukh, Emilie Cerf, Jean Marie Ruysschaert, Leonid Breydo, Sylvie Derclaye
Publikováno v:
Biochemical journal, 421 (3
Biochemical Journal
Biochemical Journal, Portland Press, 2009, 421 (3), pp.415-423. ⟨10.1042/BJ20090379⟩
Biochemical Journal
Biochemical Journal, Portland Press, 2009, 421 (3), pp.415-423. ⟨10.1042/BJ20090379⟩
AD (Alzheimer's disease) is linked to Abeta (amyloid beta-peptide) misfolding. Studies demonstrate that the level of soluble Abeta oligomeric forms correlates better with the progression of the disease than the level of fibrillar forms. Conformation-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c5723097efe169c02c96b25c0b8046
https://pubmed.ncbi.nlm.nih.gov/19435461
https://pubmed.ncbi.nlm.nih.gov/19435461
Autor:
Huaxi Xu, David Sweeney, Gopal Thinakaran, Paul Greengard, Sam Gandy, Sangram S. Sisodia, Rong Wang, Amy C. Y. Lo
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 94(8)
β-amyloid protein (Aβ) formation was reconstituted in permeabilized neuroblastoma cells expressing human Alzheimer β-amyloid precursor protein (βAPP) harboring the Swedish double mutation associated with familial early- onset Alzheimer disease. P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7957fc75d5a092f47013ec8f80b1f2f7
https://pubmed.ncbi.nlm.nih.gov/9108049
https://pubmed.ncbi.nlm.nih.gov/9108049