Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Amyloid beta-Peptides/cerebrospinal fluid"'
Autor:
Anna-Lena Haas, Pauline Olm, Janine Utz, Eva-Maria Siegmann, Philipp Spitzer, Anna Florvaag, Manuel Alexander Schmidt, Arnd Doerfler, Piotr Lewczuk, Johannes Kornhuber, Juan Manuel Maler, Timo Jan Oberstein, for the Alzheimer’s Disease Neuroimaging Initiative
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
IntroductionAlzheimer’s disease (AD) is indicated by a decrease in amyloid beta 42 (Aβ42) level or the Aβ42/Aβ40 ratio, and by increased levels of Tau with phosphorylated threonine at position 181 (pTau181) in cerebrospinal fluid (CSF) years bef
Externí odkaz:
https://doaj.org/article/a0515777f9ec40f49d049a47a82ea07a
Autor:
Pocevičiūtė, Dovilė, Nuñez-Diaz, Cristina, Roth, Bodil, Janelidze, Shorena, Giannisis, Andreas, Hansson, Oskar, Wennström, Malin
Publikováno v:
Alzheimer's Research & Therapy, 14(1). BioMed Central
Background Alzheimer’s disease (AD) is foremost characterized by β-amyloid (Aβ)-extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation, but over the last years it has become evident that peripheral inflammation m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef7c6cecafd46218690474660fdcf38
https://pure.knaw.nl/portal/en/publications/88552aa0-acd0-4d49-be93-9829850b842b
https://pure.knaw.nl/portal/en/publications/88552aa0-acd0-4d49-be93-9829850b842b
Akademický článek
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Akademický článek
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Autor:
Niels D. Prins, Karlijn A. van den Bosch, Philip Scheltens, Iris E. Jansen, Inge M.W. Verberk, Jarith L. Ebenau, Wiesje M. van der Flier, Charlotte E. Teunissen, Sven J. van der Lee
Publikováno v:
van den Bosch, K A, Verberk, I M W, Ebenau, J L, van der Lee, S J, Jansen, I E, Prins, N D, Scheltens, P, Teunissen, C E & Van der Flier, W M 2021, ' BDNF-Met polymorphism and amyloid-beta in relation to cognitive decline in cognitively normal elderly : the SCIENCe project ', Neurobiology of Aging, vol. 108, pp. 146-154 . https://doi.org/10.1016/j.neurobiolaging.2021.08.018
Neurobiology of Aging, 108, 146-154. Elsevier Inc.
van den Bosch, K A, Verberk, I M W, Ebenau, J L, van der Lee, S J, Jansen, I E, Prins, N D, Scheltens, P, Teunissen, C E & van der Flier, W M 2021, ' BDNF-Met polymorphism and amyloid-beta in relation to cognitive decline in cognitively normal elderly : the SCIENCe project ', Neurobiology of Aging, vol. 108, pp. 146-154 . https://doi.org/10.1016/j.neurobiolaging.2021.08.018
Neurobiology of Aging, 108, 146-154. Elsevier Inc.
van den Bosch, K A, Verberk, I M W, Ebenau, J L, van der Lee, S J, Jansen, I E, Prins, N D, Scheltens, P, Teunissen, C E & van der Flier, W M 2021, ' BDNF-Met polymorphism and amyloid-beta in relation to cognitive decline in cognitively normal elderly : the SCIENCe project ', Neurobiology of Aging, vol. 108, pp. 146-154 . https://doi.org/10.1016/j.neurobiolaging.2021.08.018
Brain-derived neurotrophic factor (BNDF) plays a role in synapse integrity. We investigated in 398 cognitively normal adults (60±8years, 41% female, MMSE=28±1) the joint association of the Val66Met polymorphism of the BDNF gene (Met+/-) and plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9aec2c011c58d9cfba4cc704b2668b82
https://pubmed.ncbi.nlm.nih.gov/34601245
https://pubmed.ncbi.nlm.nih.gov/34601245
Autor:
Christine Van Broeckhoven, Isabelle Bos, Pablo Martinez-Lage, Frans R.J. Verhey, Frederik Barkhof, Alison L. Baird, Magdalini Tsolaki, Régis Bordet, Jolien Schaeverbeke, Sebastiaan Engelborghs, Pieter Jelle Visser, Olivier Blin, Zhiyong Xie, Mark Forrest Gordon, Silvy Gabel, Mara ten Kate, Carl Eckerström, Rik Vandenberghe, Jérôme Revillard, Julius Popp, Cristina Legido-Quigley, Alberto Redolfi, Giovanni B. Frisoni, Simon Lovestone, Gerald Novak, Lars Bertram, Jill C. Richardson, Johannes Streffer, Silvia Bianchetti, José Luis Molinuevo, Anders Wallin, Enrico Peira, Viktor Wottschel, Valerija Dobricic, Philip Scheltens, Henrik Zetterberg, Stephanie J.B. Vos
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-12 (2018)
Alzheimer's Research & Therapy, 10(1). BioMed Central
Alzheimer's research & therapy
Alzheimer's Research & Therapy
Alzheimer's research & therapy, vol. 10, no. 1, pp. 100
Alzheimer's Research & Therapy, 10:100. BioMed Central Ltd
Alzheimer's Research and Therapy
Alzheimer's Research and Therapy, 2018, 10 (1), pp.100. ⟨10.1186/s13195-018-0428-1⟩
Ten Kate, M, Redolfi, A, Peira, E, Bos, I, Vos, S J, Vandenberghe, R, Gabel, S, Schaeverbeke, J, Scheltens, P, Blin, O, Richardson, J C, Bordet, R, Wallin, A, Eckerstrom, C, Molinuevo, J L, Engelborghs, S, Van Broeckhoven, C, Martinez-Lage, P, Popp, J, Tsolaki, M, Verhey, F R J, Baird, A L, Legido-Quigley, C, Bertram, L, Dobricic, V, Zetterberg, H, Lovestone, S, Streffer, J, Bianchetti, S, Novak, G P, Revillard, J, Gordon, M F, Xie, Z, Wottschel, V, Frisoni, G, Visser, P J & Barkhof, F 2018, ' MRI predictors of amyloid pathology : results from the EMIF-AD Multimodal Biomarker Discovery study ', Alzheimer's Research & Therapy, vol. 10, no. 1, pp. 100 . https://doi.org/10.1186/s13195-018-0428-1
Alzheimer's Research and Therapy, Vol. 10, No 1 (2018) P. 100
Alzheimer's Research & Therapy, 10(1). BioMed Central
Alzheimer's research & therapy
Alzheimer's Research & Therapy
Alzheimer's research & therapy, vol. 10, no. 1, pp. 100
Alzheimer's Research & Therapy, 10:100. BioMed Central Ltd
Alzheimer's Research and Therapy
Alzheimer's Research and Therapy, 2018, 10 (1), pp.100. ⟨10.1186/s13195-018-0428-1⟩
Ten Kate, M, Redolfi, A, Peira, E, Bos, I, Vos, S J, Vandenberghe, R, Gabel, S, Schaeverbeke, J, Scheltens, P, Blin, O, Richardson, J C, Bordet, R, Wallin, A, Eckerstrom, C, Molinuevo, J L, Engelborghs, S, Van Broeckhoven, C, Martinez-Lage, P, Popp, J, Tsolaki, M, Verhey, F R J, Baird, A L, Legido-Quigley, C, Bertram, L, Dobricic, V, Zetterberg, H, Lovestone, S, Streffer, J, Bianchetti, S, Novak, G P, Revillard, J, Gordon, M F, Xie, Z, Wottschel, V, Frisoni, G, Visser, P J & Barkhof, F 2018, ' MRI predictors of amyloid pathology : results from the EMIF-AD Multimodal Biomarker Discovery study ', Alzheimer's Research & Therapy, vol. 10, no. 1, pp. 100 . https://doi.org/10.1186/s13195-018-0428-1
Alzheimer's Research and Therapy, Vol. 10, No 1 (2018) P. 100
Background With the shift of research focus towards the pre-dementia stage of Alzheimer’s disease (AD), there is an urgent need for reliable, non-invasive biomarkers to predict amyloid pathology. The aim of this study was to assess whether easily o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e5b0f83b58949d9cc7bd2b136091eda
http://link.springer.com/article/10.1186/s13195-018-0428-1
http://link.springer.com/article/10.1186/s13195-018-0428-1
Autor:
Frans R.J. Verhey, Lieke L. Smits, Huiberdina L. Koek, Wiesje M. van der Flier, Peter Paul De Deyn, Geert Jan Biessels, Pauline Aalten, Janne M. Papma, Inez H.G.B. Ramakers, Coen D.A. Stehouwer, Marcel Olde-Rikkert, Stefan L.C. Geijselaers, Annemieke C. Heijboer, Charlotte E. Teunissen, Fransje E. Reesink
Publikováno v:
Journal of Alzheimer's Disease, 61, 1, pp. 309-320
Journal of Alzheimers Disease, 61(1), 309-320. IOS Press BV
Journal of Alzheimer’s Disease, 61(1), 309-320. IOS Press
Journal of Alzheimer's Disease, 61(1), 309-320. IOS Press
Journal of Alzheimer's Disease
Geijselaers, S L C, Aalten, P, Ramakers, I H G B, De Deyn, P P, Heijboer, A C, Koek, H L, Olderikkert, M G M, Papma, J M, Reesink, F E, Smits, L L, Stehouwer, C D A, Teunissen, C E, Verhey, F R J, Van Der Flier, W M & Biessels, G J 2017, ' Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 309-320 . https://doi.org/10.3233/JAD-170522
Journal of Alzheimer's Disease, 61(1), 309. IOS Press
Journal of Alzheimer's Disease, 61, 309-320
Journal of Alzheimers Disease, 61(1), 309-320. IOS Press BV
Journal of Alzheimer’s Disease, 61(1), 309-320. IOS Press
Journal of Alzheimer's Disease, 61(1), 309-320. IOS Press
Journal of Alzheimer's Disease
Geijselaers, S L C, Aalten, P, Ramakers, I H G B, De Deyn, P P, Heijboer, A C, Koek, H L, Olderikkert, M G M, Papma, J M, Reesink, F E, Smits, L L, Stehouwer, C D A, Teunissen, C E, Verhey, F R J, Van Der Flier, W M & Biessels, G J 2017, ' Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease ', Journal of Alzheimer's Disease, vol. 61, no. 1, pp. 309-320 . https://doi.org/10.3233/JAD-170522
Journal of Alzheimer's Disease, 61(1), 309. IOS Press
Journal of Alzheimer's Disease, 61, 309-320
BACKGROUND: Abnormal insulin signaling in the brain has been linked to Alzheimer's disease (AD).OBJECTIVE: To evaluate whether cerebrospinal fluid (CSF) insulin levels are associated with cognitive performance and CSF amyloid-β and Tau. Additionally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c053091c515e8ab1432707f2b80688e
https://doi.org/10.3233/jad-170522
https://doi.org/10.3233/jad-170522
Autor:
Aikaterini Oikonomidi, John Corthésy, Jérôme Wojcik, Gene L. Bowman, Hugues Henry, Antonio Núñez Galindo, Loïc Dayon, Ornella Cominetti, Julius Popp, Eugenia Migliavacca
Publikováno v:
Journal of Alzheimer's Disease, Vol. 60, No 4 (2017) pp. 1641-1652
Journal of Alzheimer's disease, vol. 60, no. 4, pp. 1641-1652
Journal of Alzheimer's disease, vol. 60, no. 4, pp. 1641-1652
Cerebrospinal fluid (CSF) biomarkers of the beta-amyloid and microtubule associated protein tau metabolism have proven the capacity to improve classification of subjects developing Alzheimer's disease (AD). The blood plasma proteome was characterized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a966e22661d220d7dba459211a2c04
https://doi.org/10.3233/jad-170426
https://doi.org/10.3233/jad-170426
Publikováno v:
Journal of psychiatric research
Journal of Psychiatric Research, Vol. 90 (2017) pp. 12-20
Journal of psychiatric research, vol. 90, pp. 12-20
Journal of Psychiatric Research, Vol. 90 (2017) pp. 12-20
Journal of psychiatric research, vol. 90, pp. 12-20
Specific changes in personality profiles may represent early non-cognitive symptoms of Alzheimer's disease (AD). Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ab99e507b7fb0f90d86f4bce899907
https://doi.org/10.1016/j.jpsychires.2016.12.024
https://doi.org/10.1016/j.jpsychires.2016.12.024
Publikováno v:
Neurobiology of Aging, Vol. 52 (2017) pp. 196-213
Novel diagnostic criteria for Alzheimer's disease (AD) incorporate biomarkers, but their maturity for implementation in clinical practice at the prodromal stage (mild cognitive impairment [MCI]) is unclear. Here, we evaluate cerebrospinal fluid (CSF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cff0c4ec0df10beb58e039e53291c80e
https://doi.org/10.1016/j.neurobiolaging.2016.02.034
https://doi.org/10.1016/j.neurobiolaging.2016.02.034