Zobrazeno 1 - 10
of 294
pro vyhledávání: '"Amyloid beta plaques"'
Publikováno v:
Neurology and Therapy, Vol 13, Iss 6, Pp 1571-1595 (2024)
Abstract Alzheimer’s disease (AD) is a neurodegenerative disorder that significantly impairs cognitive and functional abilities, placing a substantial burden on both patients and caregivers. Current symptomatic treatments fail to halt the progressi
Externí odkaz:
https://doaj.org/article/a4870cfad92b4350b97da95764a25392
Autor:
Muhammad Tahir, Min Hwa Kang, Tae Ju Park, Jawad Ali, Kyonghwan Choe, Jun Sung Park, Myeong Ok Kim
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder pathologically characterized by the deposition of amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) in the brain. The accumulation of these aggregated proteins causes me
Externí odkaz:
https://doaj.org/article/3bb3d80f09ec4fa0b4ff0ffdc137fe7e
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-11 (2024)
Abstract Background Mounting data suggests that herpes simplex virus type 1 (HSV-1) is involved in the pathogenesis of AD, possibly instigating amyloid-beta (Aβ) accumulation decades before the onset of clinical symptoms. However, human in vivo evid
Externí odkaz:
https://doaj.org/article/3981710a3aa949b989ce051f621a8ca1
Autor:
Tim Bathe, Gabriela P. Hery, Jonathan A. B. Villareal, Jennifer L. Phillips, Eric M. Cohen, Rohan V. Sharma, Wangchen Tsering, Stefan Prokop
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-25 (2024)
Abstract The disease-specific accumulation of pathological proteins has long been the major focus of research in neurodegenerative diseases (ND), including Alzheimer’s disease (AD) and related dementias (RD), but the recent identification of a mult
Externí odkaz:
https://doaj.org/article/12cef3313feb4dd79e438d8394192c0c
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Microglia are the resident macrophages of the central nervous system (CNS) that control brain development, maintain neural environments, respond to injuries, and regulate neuroinflammation. Despite their significant impact on various physiological an
Externí odkaz:
https://doaj.org/article/4d579cd2e5d24e57a7d4ed0e04e04d42
Autor:
Li-Fen Liu, Yu-Tong Liu, Dan-Dan Wu, Jie Cheng, Na-Na Li, Ya-Ni Zheng, Liang Huang, Qiong-Lan Yuan
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 9, Pp 2019-2028 (2023)
Extracellular amyloid beta (Aβ) plaques are main pathological feature of Alzheimer’s disease. However, the specific type of neurons that produce Aβ peptides in the initial stage of Alzheimer’s disease are unknown. In this study, we found that 5
Externí odkaz:
https://doaj.org/article/62f2e7910e3d478294496a757bf6471e
Akademický článek
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Akademický článek
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Publikováno v:
Neural Regeneration Research, Vol 17, Iss 12, Pp 2606-2614 (2022)
Two of the most common neurodegenerative disorders – Alzheimer’s and Parkinson’s diseases – are characterized by synaptic dysfunction and degeneration that culminate in neuronal loss due to abnormal protein accumulation. The intracellular agg
Externí odkaz:
https://doaj.org/article/9d407ef1ed834b699fc63e1c81c9b3e8
Autor:
Bhagavathi Sundaram Sivamaruthi, Neha Raghani, Mehul Chorawala, Sankha Bhattacharya, Bhupendra G. Prajapati, Gehan M. Elossaily, Chaiyavat Chaiyasut
Publikováno v:
Biomedicines, Vol 11, Iss 9, p 2587 (2023)
The nuclear factor kappa B (NF-κB) pathway has emerged as a pivotal player in the pathogenesis of various diseases, including neurodegenerative illnesses like Alzheimer’s disease (AD). The involvement of the NF-κB pathway in immune system respons
Externí odkaz:
https://doaj.org/article/dcb70bb0a0664a538f07a707cbe8a885