Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Amyloid Beta 42"'
Autor:
Peter Thomas, Manon Leclerc, Kira Evitts, Caitlin Brown, Wyatt Miller, Angela J. Hanson, William A. Banks, Laura Gibbons, Kimiko Domoto‐Reilly, Suman Jayadev, Ge Li, Elaine Peskind, Jessica E. Young, the Consortium for the early identification of Alzheimer's disease‐Quebec (CIMA‐Q), Frederic Calon, Elizabeth M. Rhea
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION Brain insulin resistance and deficiency is a consistent feature of Alzheimer's disease (AD). Insulin resistance can be mediated by the surface expression of the insulin receptor (IR). Cleavage of the IR generates the soluble IR
Externí odkaz:
https://doaj.org/article/a96035dfbb90424f8896334c2188590c
Autor:
Caterina Motta, Martina Gaia Di Donna, Chiara Giuseppina Bonomi, Martina Assogna, Agostino Chiaravalloti, Nicola Biagio Mercuri, Giacomo Koch, Alessandro Martorana
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Despite the high sensitivity of cerebrospinal fluid (CSF) amyloid beta (Aβ)42 to detect amyloid pathology, the Aβ42/Aβ40 ratio (amyR) better estimates amyloid load, with higher specificity for Alzheimer’s disease (AD). Howeve
Externí odkaz:
https://doaj.org/article/5b1cd006bcd14b99b2fa34881a366471
Autor:
Kecheng Li, Xiaoli Zhou, Youren Liu, Dongyu Li, Yinyin Li, Ting Zhang, Chunyan Fu, Lin Li, Yang Hu, Li Jiang
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionBeta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer’s disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-β peptides
Externí odkaz:
https://doaj.org/article/002da5fb74d7409c94d7817c56fb1f74
Publikováno v:
Neural Regeneration Research, Vol 18, Iss 4, Pp 784-789 (2023)
The pathology of Alzheimer’s disease involves a long preclinical period, where the characteristic clinical symptoms of the changes in the brain are undetectable. During the preclinical period, homeostatic mechanisms may help prevent widespread cell
Externí odkaz:
https://doaj.org/article/f18c4884c190404aa3356436fd4a8c6b
Akademický článek
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Publikováno v:
Neuropsychiatric Disease and Treatment, Vol Volume 18, Pp 1831-1841 (2022)
Yue Wu1 *, Zhiqiang Wang2 *, Jiajun Yin,3 Bixiu Yang,2 Jie Fan,1 Zaohuo Cheng1 1Department of Geriatric Psychiatry, The Affiliated Wuxi Mental Health Center of Jiangnan University, Wuxi, People’s Republic of China; 2Department of Clinical P
Externí odkaz:
https://doaj.org/article/9a539ff1b76f4ec5996e83be3e11c9dc
Autor:
Jelena Tadic, Julia Ring, Andrea Jerkovic, Selena Ristic, Marta Maglione, Jörn Dengjel, Stephan J. Sigrist, Tobias Eisenberg
Publikováno v:
Cell Stress, Vol 6, Iss 5, Pp 61-64 (2022)
Alzheimer’s disease (AD) is the most common form of dementia with millions of people affected worldwide. Pathophysiological manifestations of AD include the extracellular accumulation of amyloid beta (Abeta) pep-tides, products of the proteolytic c
Externí odkaz:
https://doaj.org/article/c44ddf419ff94f3e8badbc73098e7b34
Autor:
Julia Ring, Jelena Tadic, Selena Ristic, Michael Poglitsch, Martina Bergmann, Nemanja Radic, Dirk Mossmann, YongTian Liang, Marta Maglione, Andrea Jerkovic, Roozbeh Hajiraissi, Marcel Hanke, Victoria Küttner, Heimo Wolinski, Andreas Zimmermann, Lana Domuz Trifunović, Leonie Mikolasch, Daiana N Moretti, Filomena Broeskamp, Julia Westermayer, Claudia Abraham, Simon Schauer, Christopher Dammbrueck, Sebastian J Hofer, Mahmoud Abdellatif, Guido Grundmeier, Guido Kroemer, Ralf J Braun, Niklas Hansen, Cornelia Sommer, Mirjana Ninkovic, Sandra Seba, Patrick Rockenfeller, Friederike‐Nora Vögtle, Jörn Dengjel, Chris Meisinger, Adrian Keller, Stephan J Sigrist, Tobias Eisenberg, Frank Madeo
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 5, Pp 1-26 (2022)
Abstract Amyloid beta 42 (Abeta42) is the principal trigger of neurodegeneration during Alzheimer’s disease (AD). However, the etiology of its noxious cellular effects remains elusive. In a combinatory genetic and proteomic approach using a yeast m
Externí odkaz:
https://doaj.org/article/4c65d2eea54842d29ae6240b593bf7ff
Akademický článek
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Publikováno v:
BMC Veterinary Research, Vol 17, Iss 1, Pp 1-14 (2021)
Abstract Background Canine cognitive dysfunction syndrome (CCDS) is a progressive neurodegenerative disorder found in senior dogs. Due to the lack of biological markers, CCDS is commonly underdiagnosed. The aim of this study was to identify potential
Externí odkaz:
https://doaj.org/article/3d00fd5a32a947f6a86752d5f066f19f