Zobrazeno 1 - 10
of 2 145
pro vyhledávání: '"Amyloid β-protein"'
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 4299-4317 (2024)
Mai Zhang,1 Yan Li,1,2 Chunli Han,3 Shiying Chu,1 Peng Yu,1 Wenbo Cheng1,2 1Mass Spectrometry Application Center, Tianjin Guoke Medical Technology Development Co., Ltd, Tianjin, People’s Republic of China; 2Institute of Biomedical Engineering and T
Externí odkaz:
https://doaj.org/article/7ccd926de64143c4b12261fc9354789d
Autor:
Heather M. Terron, Sagar J. Parikh, Samer O. Abdul-Hay, Tomoko Sahara, Dongcheul Kang, Dennis W. Dickson, Paul Saftig, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract Background Cathepsin D (CatD) is a lysosomal protease that degrades both the amyloid-β protein (Aβ) and the microtubule-associated protein, tau, which accumulate pathognomonically in Alzheimer disease (AD), but few studies have examined th
Externí odkaz:
https://doaj.org/article/c8e7a6b3cbd440008791292cdd23c305
Publikováno v:
Molecules, Vol 29, Iss 21, p 5023 (2024)
The deposition of amyloid β-protein (Aβ) in the brain is the main pathogenesis of Alzheimer’s disease (AD). The development of potent inhibitors against Aβ aggregation is one of the effective strategies to combat AD. Endogenous transthyretin (TT
Externí odkaz:
https://doaj.org/article/d249488abc8f4d1b835e1f881ff343c3
Publikováno v:
Heliyon, Vol 10, Iss 9, Pp e30523- (2024)
Alzheimer's disease (AD) is a common neurodegenerative disease in the elderly, the exact pathogenesis of which remains incompletely understood, and effective preventive and therapeutic drugs are currently lacking. Cholesterol plays a vital role in ce
Externí odkaz:
https://doaj.org/article/6150495bf7b9403ea0fcb551f5181d92
Publikováno v:
Neurobiology of Disease, Vol 193, Iss , Pp 106461- (2024)
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder with pathological features of β-amyloid (Aβ) and hyperphosphorylated tau protein accumulation in the brain, often accompanied by cognitive decline. So far, our understanding of the
Externí odkaz:
https://doaj.org/article/496be45de5644e23a3eabf7ad9cccc7d
Publikováno v:
Clinical Interventions in Aging, Vol Volume 18, Pp 1221-1232 (2023)
Meng Miao,1 Mingyang Lyu,2 Chi Zhong,1 Ying Liu3 1Department of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, People’s Republic of China; 2Haihe Laboratory of Cell Ecosystem, Tianjin, Peopl
Externí odkaz:
https://doaj.org/article/9281a990f5c142e6851c72571afee171
Autor:
Cristiano D’Andrea, Federico Angelo Cazzaniga, Edoardo Bistaffa, Andrea Barucci, Marella de Angelis, Martina Banchelli, Edoardo Farnesi, Panagis Polykretis, Chiara Marzi, Antonio Indaco, Pietro Tiraboschi, Giorgio Giaccone, Paolo Matteini, Fabio Moda
Publikováno v:
Translational Neurodegeneration, Vol 12, Iss 1, Pp 1-12 (2023)
Abstract Background The current diagnosis of Alzheimer’s disease (AD) is based on a series of analyses which involve clinical, instrumental and laboratory findings. However, signs, symptoms and biomarker alterations observed in AD might overlap wit
Externí odkaz:
https://doaj.org/article/1a3f7a382ad8441eb6790e942af636f3
Publikováno v:
Zhongguo gonggong weisheng, Vol 39, Iss 5, Pp 660-664 (2023)
Alzheimer′s disease (AD), as a neurodegenerative disease of the central nervous system, often progresses insidiously. AD is known to have long disease course and heavy disease burden and there is no cure for it currently. The proper intervention at
Externí odkaz:
https://doaj.org/article/e704a598a02740508827741f29acffa1
Autor:
MEI Chenghan, CHEN Beibei
Publikováno v:
Shiyan dongwu yu bijiao yixue, Vol 43, Iss 2, Pp 186-193 (2023)
Glucagon-like peptide 1 (GLP-1) is a kind of incretin produced in the intestinal with multiple pharmacological effects, which can stimulate insulin secretion effectively. Various GLP-1 analogues have been widely used in the treatment of type 2 diabet
Externí odkaz:
https://doaj.org/article/5eae0042bf0947bfbad203277b523964
Autor:
Rachit Pandey, Brigita Urbanc
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 774 (2024)
Alzheimer’s disease (AD) is a neurological disorder associated with amyloid β-protein (Aβ) assembly into toxic oligomers. In addition to the two predominant alloforms, Aβ1−40 and Aβ1−42, other C-terminally truncated Aβ peptides, including
Externí odkaz:
https://doaj.org/article/b189b886963f4638ab6817ca7cb01556