Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Amyloid/metabolism"'
Akademický článek
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Autor:
Maria A. Tikhonova, Tamara G. Amstislavskaya, Victor M. Belichenko, Larisa A. Fedoseeva, Sergey P. Kovalenko, Ekaterina E. Pisareva, Alla S. Avdeeva, Nataliya G. Kolosova, Nikolai D. Belyaev, Lyubomir I. Aftanas
Publikováno v:
BMC Neuroscience, Vol 19, Iss S1, Pp 15-28 (2018)
Abstract Background The dominant hypothesis about the pathogenesis of Alzheimer’s disease (AD) is the “amyloid cascade” concept and modulating the expression of proteins involved in the metabolism of amyloid-beta (Aβ) is proposed as an effecti
Externí odkaz:
https://doaj.org/article/e36633a412f3407296603b97987811c4
Autor:
Daniel Otzen
Publikováno v:
Otzen, D E 2022, ' Functional amyloid in a lipid-like environment : a merry dance of many steps ', Essays in Biochemistry, vol. 66, no. 7 . https://doi.org/10.1042/EBC20220062
Functional amyloid, which unlike its pathological counterpart serves a biological purpose, is produced in a carefully orchestrated sequence of events. In bacteria, the major amyloid component is transported over the periplasm and through the outer me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebba106d4448d4b0d6b675881aea2b90
https://doi.org/10.1042/ebc20220062
https://doi.org/10.1042/ebc20220062
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Esther Stroo, Leen Janssen, Olga Sin, Wytse Hogewerf, Mirjam Koster, Liesbeth Harkema, Sameh A Youssef, Natalie Beschorner, Anouk HG Wolters, Bjorn Bakker, Lore Becker, Lilian Garrett, Susan Marschall, Sabine M Hoelter, Wolfgang Wurst, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Amantha Thathiah, Floris Foijer, Bart van de Sluis, Jan van Deursen, Matthias Jucker, Alain de Bruin, Ellen AA Nollen
Publikováno v:
Life science alliance 6(7), e202201730 (2023). doi:10.26508/lsa.202201730
In age-related neurodegenerative diseases, like Alzheimer’s and Parkinson’s, disease-specific proteins become aggregation-prone and form amyloid-like deposits. Depletion of SERF proteins ameliorates this toxic process in worm and human cell model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2dc28445569fccfa99cc8b093ea779
https://pub.dzne.de/record/257883
https://pub.dzne.de/record/257883
Autor:
Gabriel Servilha-Menezes, Rui M.P. da Silva-Júnior, Melita Salkovic-Petrisic, Suélen Santos Alves, Jan Homolak, Norberto Garcia-Cairasco
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Almost 115 years ago, Alois Alzheimer described Alzheimer’s disease (AD) for the first time. Since then, many hypotheses have been proposed. However, AD remains a severe health public problem. The current medical approaches for AD are limited to sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce9c906714bf33029469a2037701a83a
https://doi.org/10.3233/jad-210234
https://doi.org/10.3233/jad-210234
Autor:
Walter Maetzler, Inga Liepelt, Matthias Reimold, Gerald Reischl, Christoph Solbach, Clemens Becker, Claudia Schulte, Thomas Leyhe, Stefanie Keller, Arthur Melms, Thomas Gasser, Daniela Berg
Publikováno v:
Neurobiology of Disease, Vol 34, Iss 1, Pp 107-112 (2009)
About one fourth of Lewy body disease (LBD) patients show cortical β-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [11C]PIB-PET, we tested whether LBD patients with β-amyloid burden differ from those without with respect to de
Externí odkaz:
https://doaj.org/article/13b444c51677461a8e196c251e4dfa4d
Publikováno v:
Der Nervenarzt 93(6), 605-611 (2022). doi:10.1007/s00115-021-01213-x
ZusammenfassungDie zerebrale Amyloidangiopathie (CAA) tritt trotz verschiedener Pathomechanismen häufig koinzident zur Alzheimer-Demenz auf. Sie moduliert kognitive Defizite im Rahmen der Alzheimer-Erkrankung (AD) annehmbar durch additive Effekte, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0000634d066425d4899a0cd47338f034
https://pub.dzne.de/record/163371
https://pub.dzne.de/record/163371
Publikováno v:
Høilund-Carlsen, P F & Alavi, A 2021, ' Aducanumab (Marketed as Aduhelm) Approval Is Likely Based on Misinterpretation of PET Imaging Data ', Journal of Alzheimer's Disease, vol. 84, no. 4, pp. 1457-1460 . https://doi.org/10.3233/JAD-215275
According to the FDA, aducanumab (Aduhelm), the recently approved anti-Alzheimer drug, reduces the level of cerebral amyloid plaques—a hallmark finding in patients with Alzheimer’s disease—and this will result in a reduction in clinical decline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ec44287cb0cab617bc61bc6ce999df
https://portal.findresearcher.sdu.dk/da/publications/9db02f46-3434-400d-83b5-956c139c5049
https://portal.findresearcher.sdu.dk/da/publications/9db02f46-3434-400d-83b5-956c139c5049
Autor:
Marie V. Lukassen, Henrik Vorum, Carsten Scavenius, Casper Bøjer Rasmussen, Kasper Runager, Michael W. Risør, Gunna Christiansen, Mette Richner, Emilie Hage Mogensen, Ebbe Toftgaard Poulsen, Nadia Sukusu Nielsen, Jan J. Enghild
Publikováno v:
Poulsen, E T, Nielsen, N S, Scavenius, C, Mogensen, E H, Risør, M W, Runager, K, Lukassen, M V, Rasmussen, C B, Christiansen, G, Richner, M, Vorum, H & Enghild, J J 2019, ' The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA119.009050
Poulsen, E T, Nielsen, N S, Scavenius, C, Mogensen, E H, Risør, M W, Runager, K, Lukassen, M V, Rasmussen, C B, Christiansen, G, Richner, M, Vorum, H & Enghild, J J 2019, ' The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation ', The Journal of Biological Chemistry, vol. 294, no. 31, pp. 11817-11828 . https://doi.org/10.1074/jbc.RA119.009050
Poulsen, E T, Nielsen, N S, Scavenius, C, Mogensen, E H, Risør, M W, Runager, K, Lukassen, M V, Rasmussen, C B, Christiansen, G, Richner, M, Vorum, H & Enghild, J J 2019, ' The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation ', Journal of Biological Chemistry, vol. 294, no. 31, pp. 11817-11828 . https://doi.org/10.1074/jbc.RA119.009050
The Journal of Biological Chemistry
Poulsen, E T, Nielsen, N S, Scavenius, C, Mogensen, E H, Risør, M W, Runager, K, Lukassen, M V, Rasmussen, C B, Christiansen, G, Richner, M, Vorum, H & Enghild, J J 2019, ' The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation ', The Journal of Biological Chemistry, vol. 294, no. 31, pp. 11817-11828 . https://doi.org/10.1074/jbc.RA119.009050
Poulsen, E T, Nielsen, N S, Scavenius, C, Mogensen, E H, Risør, M W, Runager, K, Lukassen, M V, Rasmussen, C B, Christiansen, G, Richner, M, Vorum, H & Enghild, J J 2019, ' The serine protease HtrA1 cleaves misfolded transforming growth factor β-induced protein (TGFBIp) and induces amyloid formation ', Journal of Biological Chemistry, vol. 294, no. 31, pp. 11817-11828 . https://doi.org/10.1074/jbc.RA119.009050
The Journal of Biological Chemistry
The serine protease high-temperature requirement protein A1 (HtrA1) is associated with protein-misfolding disorders such as Alzheimer's disease and transforming growth factor b-induced protein (TGFBIp)-linked corneal dystrophy. In this study, using s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7b89321d2e2e3c4461f45a54e5e1d0
https://doi.org/10.1074/jbc.ra119.009050
https://doi.org/10.1074/jbc.ra119.009050