Caractérisation structurale des protéines à doigt de zinc intrinsèquement désordonnées amyloïdogènes DPF3b et DPF3a

Autor: Julien Mignon, Denis Mottet, Tanguy Leyder, Vladimir N. Uversky, Eric A. Perpète, Catherine Michaux

Publikováno v: International Journal of Biological Macromolecules. 218:57-71

Double PHD fingers 3 (DPF3) is a zinc finger protein, found in the BAF chromatin remodelling complex, and is involved in the regulation of gene expression. Two DPF3 isoforms have been identified, respectively named DPF3b and DPF3a. Very limited struc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc147206dc96fc2767431fdf976a03d5
https://doi.org/10.1016/j.ijbiomac.2022.07.102

Unveiling the Metal-Dependent Aggregation Properties of the C-terminal Region of Amyloidogenic Intrinsically Disordered Protein Isoforms DPF3b and DPF3a

Autor: Leyder, Tanguy, Mignon, Julien, Mottet, Denis, Michaux, Catherine

Publikováno v: Leyder, T, Mignon, J, Mottet, D & Michaux, C 2022, ' Unveiling the Metal-Dependent Aggregation Properties of the C-terminal Region of Amyloidogenic Intrinsically Disordered Protein Isoforms DPF3b and DPF3a ', International Journal of Molecular Sciences, vol. 23, no. 23, 15291 . https://doi.org/10.3390/ijms232315291

Double-PHD fingers 3 (DPF3) is a BAF-associated human epigenetic regulator, which is increasingly recognised as a major contributor to various pathological contexts, such as cardiac defects, cancer, and neurodegenerative diseases. Recently, we unveil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4291::00e74949f923522f369b21fbced5c175
https://pure.unamur.be/ws/files/70989905/ijms_23_15291_published_paper.pdf

Proteomic dissection of Alzheimer’s disease pathology

AD pathology is characterized by the presence of amyloid beta (Aβ) aggregates, as plaques in the brain parenchyma and around the brain vasculature as Cerebral Amyloid Angiopathy (CAA). In addition, AD pathology is hallmarked by the presence of intra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4612::ffd54fdef28076efadb69abd91ac12f1
https://research.vu.nl/en/publications/ae7045de-7b97-42dc-876f-405c3d4b1e13

Quantification de l'atteinte musculaire par IRM dans la polyneuropathie amyloïde familiale : mise en évidence d'un biomarqueur d'intérêt

Autor: Durelle, Clémence

Publikováno v: Sciences du Vivant [q-bio]. 2022

Objectif : étudier en imagerie par résonance magnétique (IRM) l'infiltration graisseuse (FG) et les modifications du transfert d’aimantation (MTR) des muscles de la cuisse et de la jambe dans la polyneuropathie amyloïde familiale à transthyré

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3430::09248b863ce5e0ee1e6e2fba9041b690
https://dumas.ccsd.cnrs.fr/dumas-03706075/document

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