Concentration‐Dependent Interactions of Amphiphilic PiB Derivative Metal Complexes with Amyloid Peptides Aβ and Amylin**

Autor: Sara Lacerda, Éva Tóth, Carlos F. G. C. Geraldes, Inga Relich, Christelle Hureau, Jean-François Morfin, Zoltán Garda, Agnès Pallier, Alexandre C. Oliveira, Saida Majdoub

Publikováno v: Chemistry – A European Journal
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2021, 27, pp.2009-2020. ⟨10.1002/chem.202004000⟩
Chemistry-A European Journal, 2021, 27, pp.2009-2020. ⟨10.1002/chem.202004000⟩

International audience; Metal chelates targeted to amyloid peptides are widely explored as diagnostic tools or therapeutic agents. The attachment of a metal complex to amyloid recognition units typically leads to a decrease in peptide affinity. We sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c90b7022bc033aca54df52d252e02bdf

Amylin brain circuitry

Autor: Lavinia Boccia, Christelle Le Foll, Salome Gamakharia, Thomas A. Lutz, Lynda Whiting, Bernd Coester

Publikováno v: Peptides. 132:170366

Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e400a9c6d08a5a29b5f4721194f9ce0
https://doi.org/10.1016/j.peptides.2020.170366

Antipsychotic-Like Actions of the Satiety Peptide, Amylin, in Ventral Striatal Regions Marked by Overlapping Calcitonin Receptor and RAMP-1 Gene Expression

Autor: Vaishali P. Bakshi, Quentin Z. Bremer, Brian A. Baldo, Sarah K. Baisley

Publikováno v: The Journal of Neuroscience. 34:4318-4325

Amylin is a calcitonin-related peptide co-secreted with insulin, which produces satiety through brainstem-localized receptors; however, its effects in forebrain are poorly understood. The nucleus accumbens shell (AcbSh) exhibits among the densest con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf38bebc8d4186bcfdd2fbc5b7d4a2b8
https://doi.org/10.1523/jneurosci.2260-13.2014

Cholesterol Regulates Assembly of Human Islet Amyloid Polypeptide on Model Membranes

Autor: Won-Jin Cho, Aleksandar Jeremic, Saurabh Trikha

Publikováno v: Journal of Molecular Biology. 393:765-775

Amylin, a 37-aa pancreatic hormone, is the major constituent of islet amyloid, a hallmark of type II diabetes mellitus. Recent studies have revealed a pivotal role of anionic phospholipids in membrane-catalyzed amylin fibrillogenesis and aggregation.

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https://doi.org/10.1016/j.jmb.2009.08.055

Amylin and Related Proteins: Physiology and Pathophysiology

Autor: Garth J. S. Cooper

Publikováno v: Comprehensive Physiology

The sections in this article are: 1 Protein Chemistry of Amylin 1.1 Isolation, Structure, Nomenclature, and Evolutionary Relationships 1.2 Chemical Synthesis 1.3 Molecular Structure of Soluble Amylin 1.4 Amylin as the Monomer of Islet Amyloid 2 Molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::728468079973e0a0dca87d7f3383c03f
https://doi.org/10.1002/cphy.cp070210