An intact C-terminal end of albumin is required for its long half-life in humans

Autor: Malin C. Bern, Inger Sandlie, Kasper D. Rand, Cláudia Azevedo, Algirdas Grevys, Jan Terje Andersen, Jeannette Nilsen, Bjørn Dalhus, John J Wilson, Maria Stensland, Derry C. Roopenian, Stephen O. Brennan, Kine Marita Knudsen Sand, Esben Trabjerg

Publikováno v: Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Nilsen, J, Trabjerg, E, Grevys, A, Azevedo, C, Brennan, S O, Stensland, M, Wilson, J, Sand, K M K, Bern, M, Dalhus, B, Roopenian, D C, Sandlie, I, Rand, K D & Andersen, J T 2020, ' An intact C-terminal end of albumin is required for its long half-life in humans ', Communications Biology, vol. 3, no. 1, 181 . https://doi.org/10.1038/s42003-020-0903-7
Communications Biology, 3 (1)
Communications Biology

Albumin has an average plasma half-life of three weeks and is thus an attractive carrier to improve the pharmacokinetics of fused therapeutics. The half-life is regulated by FcRn, a cellular receptor that protects against intracellular degradation. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee2ca81be9d054502e8fe07555c5462
http://link.springer.com/article/10.1038/s42003-020-0903-7

Pancreasletsel na buiktrauma bij kinderen: lastig te diagnosticeren en te behandelen

Autor: Fennema, Eelco M, Nellensteijn, David R, Nieuwenhuijs, Vincent B, van Rheenen, Patrick F, ten Duis, Henk-Jan, Hulscher, Jan B F

Publikováno v: Nederlands Tijdschrift voor Geneeskunde, 155(18):A2406. NLM (Medline)

Traumatic injury of the pancreas is rare in children. It is often difficult to diagnose due to the lack of signs and symptoms, and shortly after trauma laboratory values may be normal. In addition, ultrasound and CT are often not specific. The treatm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=narcis______::4fc6ef8cbb9faed8890fa2edb77a6ea6
https://research.rug.nl/en/publications/8d436e17-43af-4db6-bbe1-5c260ecc6c54

Ameliorative effect of adalimumab on experimentally induced acute pancreatitis in rats

Autor: Yilmaz M, Tekekoglu S, Herek O, Ozmen O, Sahinduran S, Buyukoglu T

OBJECTIVES: In this study, the effects of adalimumab (ADA), a fully humanized IgG1 monoclonal antibody to tumor necrosis factor α, on experimentally acute pancreatitis (AP) were examined. METHODS: Healthy Wistar rats (n = 32) were randomly divided i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3566::c4bb595b21017ec0eec991e5464fd4b4

Acute pancreatitis

Autor: Jean-Louis Frossard, Michael L Steer, Catherine M Pastor

Publikováno v: The Lancet, Vol. 371, No 9607 (2008) pp. 143-52
Lancet

Acute pancreatitis is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom, and increased concentrations of serum amylase and lipase confirm the diagnosis. Pancreatic injury is mild in 80% of patients, who recover

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f766e7d343adc105972654b7f9d49897
https://archive-ouverte.unige.ch/unige:793

Neutrophil depletion--but not prevention of Kupffer cell activation--decreases the severity of cerulein-induced acute pancreatitis

Autor: Antoine Hadengue, Catherine M. Pastor, Alain Vonlaufen, Philippe Morel, Jean-Louis Frossard, Fabianna Georgi

Publikováno v: World Journal of Gastroenterology, Vol. 12, No 8 (2006) pp. 1219-24

To determine whether neutrophil depletion and Kupffer cell inhibition might combine their protective effects to decrease the severity of acute pancreatitis.Mice had cerulein administration to induce acute pancreatitis and were pretreated with either

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87bc96af93f2b2179bc3e550809b8211
https://archive-ouverte.unige.ch/unige:38717