Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation.

Autor: Stephen R Spindler, Rui Li, Joseph M Dhahbi, Amy Yamakawa, Patricia Mote, Rolf Bodmer, Karen Ocorr, Renee T Williams, Yinsheng Wang, Kenneth P Ablao

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e39581 (2012)

Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals. Here we show that simvastatin significantly increased th

Externí odkaz: https://doaj.org/article/d3ca8009de6843b5a3868d19b5cff627

Health-Related Quality of Life After Community-Acquired Septic Shock in Children With Preexisting Severe Developmental Disabilities

Autor: Emily Stock, Yensy Zetino, Carolann Twelves, C. J. Jayachandran, Christopher J. L. Newth, Richard Holubkov, James W. Varni, Courtney Merritt, Lisa Steele, Ashley Wolfe, Ann Pawluszka, Mark W. Hall, Teresa Liu, Jeni Kwok, Michael J. Bell, Ranjit S. Chima, Murray M. Pollack, Elyse Tomanio, Samuel Sorenson, Hector R. Wong, Melanie Lulic, Erin Sullivan, Anil Sapru, Toni Yunger, Neda Ashtari, Robert A. Berg, Erin Stoneman, Michael W. Quasney, Andrew J. Yates, Todd C. Carpenter, Laura Benken, J. Carcillo, Aline B Maddux, Kathleen L. Meert, Kristi Flick, Anna E. Ratiu, Stephanie Bisping, Catherine Chen, Maggie Flowers, Whit Coleman, Diane Hession, Kelli A. Krallman, Jerry J. Zimmerman, John T. Berger, Rick Harrison, Deana Rich, Amy Yamakawa, Sabrina M. Heidemann, Athena F. Zuppa, Ruth Grosskreuz, Alan Abraham, Anne McKenzie, Josey Hensley, Wren Haaland, Patrick S. McQuillen, J. Michael Dean, Angie Webster, Peter M. Mourani, Jeri Burr, Diane Ladell, Kathryn B. Whitlock, Thomas P. Shanley, Andrew Nicklawsky, Alle Rutebemberwa, Joseph A. Carcillo, Ron W Reeder, Leighann Koch, David L. Wessel, Mary Ann DiLiberto, Derek Salud, Yamila Sierra, Julie McGalliard, Russell Banks

Publikováno v: Pediatr Crit Care Med

OBJECTIVES To serially evaluate health-related quality of life during the first year after community-acquired septic shock in children with preexisting severe developmental disabilities and explore factors associated with health-related quality of li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944dd470cd5d6299c46d509dcc476d4e
https://pubmed.ncbi.nlm.nih.gov/33156209

β1-Adrenergic receptor blockade extends the life span of Drosophila and long-lived mice

Autor: Stephen R. Spindler, Patricia L. Mote, Rui Li, Joseph M. Dhahbi, Amy Yamakawa, James M. Flegal, Daniel R. Jeske, Alex L. Lublin

Publikováno v: AGE. 35:2099-2109

Chronic treatment with β-adrenergic receptor (βAR) agonists increases mortality and morbidity while βAR antagonists (β-blockers) decrease all-cause mortality for those at risk of cardiac disease. Levels of sympathetic nervous system βAR agonists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee3a1011faf82206c84cb39d4ae5495
https://doi.org/10.1007/s11357-012-9498-3

Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila

Autor: Joseph M. Dhahbi, Rui Li, Stephen R. Spindler, Amy Yamakawa, Frank Sauer

Publikováno v: PLoS ONE
PLoS ONE, Vol 7, Iss 2, p e29782 (2012)

Protein kinase signaling cascades control most aspects of cellular function. The ATP binding domains of signaling protein kinases are the targets of most available inhibitors. These domains are highly conserved from mammals to flies. Herein we descri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1280df802c791f69e33a898d670cb2
https://pubmed.ncbi.nlm.nih.gov/22363408

5′ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction

Autor: Patricia L. Mote, David I. K. Martin, Dario Boffelli, Stephen R. Spindler, Hani Atamna, Joseph M. Dhahbi, Amy Yamakawa

Publikováno v: Dhahbi, Joseph M; Spindler, Stephen R; Atamna, Hani; Yamakawa, Amy; Boffelli, Dario; Mote, Patricia; et al.(2013). 5¿ tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction. BMC Genomics, 14(1), 298. doi: http://dx.doi.org/10.1186/1471-2164-14-298. Retrieved from: http://www.escholarship.org/uc/item/3r04x6hb
BMC Genomics

Background Small RNAs complex with proteins to mediate a variety of functions in animals and plants. Some small RNAs, particularly miRNAs, circulate in mammalian blood and may carry out a signaling function by entering target cells and modulating gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8edf3c8f1c9dcd3fcf5d832be0a4cfa