Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amy Y Grahn"'
Autor:
Kim Schadt, Jeffrey W. Sherman, Tom Vescio, Lauren A. Hauser, Julie Ball, Ashley McCormick, S. H. Subramony, Jennifer M. Farmer, Yi Na Dong, Renee Perdok, Susan Perlman, Katherine D. Mathews, Shana E. McCormack, Amy Y. Grahn, David A. Lynch, Alicia Brocht, McKenzie Wells
Publikováno v:
Annals of Clinical and Translational Neurology. 6:546-553
Objective In vitro, in vivo, and open-label studies suggest that interferon gamma (IFN-γ 1b) may improve clinical features in Friedreich Ataxia through an increase in frataxin levels. The present study evaluates the efficacy and safety of IFN-γ 1b
Publikováno v:
Current Medical Research and Opinion. 31:407-420
To evaluate the safety of the fixed combination of ibuprofen and famotidine compared with ibuprofen alone from two 24-week, multicenter, double-blind trials designed to evaluate the comparative incidence of endoscopically documented upper gastrointes
Autor:
Frank, Buttgereit, Jeffrey D, Kent, Robert J, Holt, Amy Y, Grahn, Patricia, Rice, Rieke, Alten, Yusuf, Yazici
Publikováno v:
Bulletin of the Hospital for Joint Disease (2013). 73(3)
Morning stiffness, a common patient reported symptom in rheumatoid arthritis, is associated with an increase in early morning inflammatory cytokines and significant disability. Little is known about categorical morning stiffness responses to glucocor
Autor:
Amy Y. Grahn, Mayer Fishman, Nevena Damjanov, Jeffrey W. Sherman, Michael P. Kane, Jill Fiedler-Kelly, Jeanne L. Dul, Antoinette R. Tan, Diane Lecomte, Eric H. Rubin, Thaddeus H. Grasela, Gerald J. Fetterly
Publikováno v:
Clinical Cancer Research. 14:5856-5863
Purpose: To evaluate the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetics of liposome-entrapped paclitaxel easy-to-use (LEP-ETU) and to characterize the relationship between LEP-ETU concentrations and the time course
Publikováno v:
The Physician and sportsmedicine.
To further characterize time-to-first pain relief, effect size, correlations between various outcome measures and durability of relief for single-tablet naproxen 500 mg/esomeprazole 20 mg (NAP/ESO) given twice daily and celecoxib (CEL) (200 mg) given
Autor:
Jeffery A. Nieves, Elias Obeid, R. Katherine Alpaugh, Elizabeth R. Plimack, Crystal S. Denlinger, Daniel M. Geynisman, Efrat Dotan, David Crouteau, John O'Neill, Lainie P. Martin, Alexander W. MacFarlane, Angela Jain, Kim Costello, Amy Y. Grahn, Kerry S. Campbell, Essel Dulaimi, Matthew Zibelman, Hossein Borghaei
Publikováno v:
Journal of Clinical Oncology. 35:97-97
97 Background: IFN-gamma is a known activator of PD-L1 expression and plays a key role in immune activation. We present initial correlative peripheral blood findings after the first 2 cohorts of pts enrolled in a phase I trial of combined IFN-gamma/N
Publikováno v:
Postgraduate medicine. 126(4)
Although anti-inflammatory doses of ibuprofen are very effective in treating the signs and symptoms of osteoarthritis (OA), they come with an increased risk for gastrointestinal damage which can limit their use and decrease patient adherence to thera
Autor:
David A. Peura, Amy Y. Grahn, Donald Jung, Robert J. Holt, George F. Tidmarsh, Julie Ball, Jeffery D. Kent
Publikováno v:
Journal of Drug Assessment
Objective Famotidine given at a dose of 80 mg/day is effective in preventing NSAID-induced gastropathy. The aim of this proof of concept study was to compare twice a day (BID) vs 3-times a day (TID) administration of this total dose of famotidine on
Autor:
Ton J. Rabelink, Robert J. Padley, Amy Y. Grahn, Anton W. M. Van Weerdt, Marina L. H. Honing, Yonghong P. Yang, Marianne C. Verhaar, Paul J. Morrison
Publikováno v:
British Journal of Clinical Pharmacology. 49:562-573
Aims Endothelins (ETs) may play a role in the pathogenesis of a variety of cardiovascular diseases. The present study was designed to investigate the pharmacokinetic and pharmacodynamic effects of the orally active ETA selective receptor antagonist A
Publikováno v:
The American Journal of Gastroenterology
OBJECTIVES: We performed two 24-week double-blind trials (REDUCE-1 and -2 (Registration Endoscopic Studies to Determine Ulcer Formation of HZT-501 Compared with Ibuprofen: Efficacy and Safety Studies)) to assess whether double-dose famotidine given i