Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Amy Winship"'
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0129110 (2015)
The placenta forms the interface between the maternal and fetal circulation and is critical for the establishment of a healthy pregnancy. Trophoblast cell proliferation, migration and invasion into the endometrium are fundamental events in the initia
Externí odkaz:
https://doaj.org/article/e36ad26bf2f14734b32660c688f786d9
Publikováno v:
Current Opinion in Endocrine and Metabolic Research. 18:15-28
Ovarian damage, resulting in oocyte death, loss of endocrine function and infertility, is a well-documented side effect of many traditional, cytotoxic cancer therapies. However, the landscape of cancer therapies is rapidly changing. Women are now als
Publikováno v:
Journal of Ovarian Research, Vol 13, Iss 1, Pp 1-11 (2020)
Journal of Ovarian Research
Journal of Ovarian Research
Background Accurate evaluation of primordial follicle numbers in mouse ovaries is an essential endpoint for studies investigating how endogenous and exogenous insults, such as maternal aging and chemotherapy, impact the ovarian reserve. In this study
Autor:
Urooza C. Sarma, Meaghan Griffiths, Amy Winship, Kelly-Anne Phillips, Karla J. Hutt, Carolina Lliberos Requesens
Publikováno v:
Human Reproduction. 35:1864-1874
STUDY QUESTION What is the impact of the poly(ADP-ribose) polymerase (PARP) inhibitor, olaparib, alone or in combination with chemotherapy on the ovary in mice? SUMMARY ANSWER Olaparib treatment, when administered alone, depletes primordial follicle
Publikováno v:
Proc Natl Acad Sci U S A
Female fertility and offspring health are critically dependent on an adequate supply of high-quality oocytes, the majority of which are maintained in the ovaries in a unique state of meiotic prophase arrest. While mechanisms of DNA repair during meio
Autor:
Kelly L Walton, Monica P Goney, Zoe Peppas, Jessica M Stringer, Amy Winship, Karla Hutt, Georgia Goodchild, Shreya Maskey, Karen L Chan, Emilie Brûlé, Daniel J Bernard, William A Stocker, Craig A Harrison
Publikováno v:
Endocrinology. 163(4)
Inhibins are members of the transforming growth factor-β family, composed of a common α-subunit disulfide-linked to 1 of 2 β-subunits (βA in inhibin A or βB in inhibin B). Gonadal-derived inhibin A and B act in an endocrine manner to suppress th
Publikováno v:
Human Reproduction. 36
Study question Does the uterus sustain direct and long-term damage following radiotherapy, independent of ovarian damage? Summary answer Radiotherapy causes direct and long-term uterine damage. Ovariectomised and hormonally supplemented mice experien
Publikováno v:
Journal of Visualized Experiments.
Sexually reproducing female mammals are born with their entire lifetime supply of oocytes. Immature, quiescent oocytes are found within primordial follicles, the storage unit of the female germline. They are non-renewable, thus their number at birth
Autor:
Wan Tinn Teh, William J. Ledger, Amy Winship, K Stern, Richard A. Anderson, S Chander, Peter Rogers, Roger Hart, A Dobrotwir, Genia Rozen, Orla McNally, M Umstad, Karla J. Hutt
Publikováno v:
Human Reproduction Open
STUDY QUESTIONWhat is the evidence to guide the management of women who wish to conceive following abdominopelvic radiotherapy (AP RT) or total body irradiation (TBI)?SUMMARY ANSWERPregnancy is possible, even following higher doses of post-pubertal u
Publikováno v:
BMJ Open
IntroductionBRCA1/2 gene mutations increase risk of breast and/or ovarian cancer and may have implications for reproductive health. Indirect biomarkers of the ovarian primordial follicle pool (anti-Müllerian hormone (AMH)) and one small study in fem