Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation

Autor: Amy Winans, Sean R. Collins, Tobias Meyer

Publikováno v: eLife, vol 5, iss FEBRUARY2016
eLife, Vol 5 (2016)
eLife
Winans, AM; Collins, SR; & Meyer, T. (2016). Waves of actin and microtubule polymerization drive microtubule-based transport and neurite growth before single axon formation. eLife, 5(FEBRUARY2016). doi: 10.7554/eLife.12387. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/237412mk

Many developing neurons transition through a multi-polar state with many competing neurites before assuming a unipolar state with one axon and multiple dendrites. Hallmarks of the multi-polar state are large fluctuations in microtubule-based transpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6cedfe3af5ffcbdd291aa3aa7298758
https://escholarship.org/uc/item/237412mk

Amyloid-β Fibrillogenesis Seeded by Interface-Induced Peptide Misfolding and Self-Assembly

Autor: Shelli L. Frey, Eva Y. Chi, Amy Winans, Jaroslaw Majewski, K. Kjaer, Ka Yee C. Lee, K. Lam

Publikováno v: Biophysical Journal. 98:2299-2308

The amphipathicity of the natively unstructured amyloid-beta (Abeta40) peptide may play an important role in its aggregation into beta-sheet rich fibrils, which is linked to the pathogenesis of Alzheimer's disease. Using the air/subphase interface as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b04fa41ef5d14c136c9d290122e303
https://doi.org/10.1016/j.bpj.2010.01.056

Author response: Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

Autor: Tom A. Hartl, Matthew P. Scott, Amy Winans, Xuecai Ge, Ljiljana Milenkovic, Kaye Suyama, Tobias Meyer, Teresa Purzner

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b10aa41aac63123cad288c3c65dbfaf
https://doi.org/10.7554/elife.07068.020

Lipid membrane templates the ordering and induces the fibrillogenesis of Alzheimer's disease amyloid-beta peptide

Autor: Eva Y, Chi, Canay, Ege, Amy, Winans, Jaroslaw, Majewski, Guohui, Wu, Kristian, Kjaer, Ka Yee C, Lee

Publikováno v: Proteins. 72(1)

The lipid membrane has been shown to mediate the fibrillogenesis and toxicity of Alzheimer's disease (AD) amyloid-beta (Abeta) peptide. Electrostatic interactions between Abeta40 and the phospholipid headgroup have been found to control the associati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2f490a8e33ec4657941315317cdf95aa
https://pubmed.ncbi.nlm.nih.gov/18186465