Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Amy Wiebesiek"'
Autor:
Andrew P. Degnan, Haiquan Fang, Tatyana Zvyaga, Zuzana Haarhoff, Claude A. Quesnelle, Melissa Kramer, Frank Marsilio, Richard A. Westhouse, John S. Tokarski, Shilpa Madari, Jiuqiao Zhao, Amy Wiebesiek, Chunhong Yan, Francis Y. Lee, Michael Sinz, John Morrison, Jean Simmermacher-Mayer, Carolynn Fanslau, Steven Sheriff, Lisa Huang, Ashvinikumar V. Gavai, Chunshan Xie, Matthew D. Hill, Gerry Everlof
Publikováno v:
Bioorganicmedicinal chemistry letters. 51
We describe our efforts to introduce structural diversity to a previously described triazole-containing N1-carboline series of bromodomain and extra-terminal (BET) inhibitors. N9 carbolines were designed to retain favorable binding interactions that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ada735600c02c9c410a77e52ab96e515
https://pubmed.ncbi.nlm.nih.gov/34560263
https://pubmed.ncbi.nlm.nih.gov/34560263
Autor:
Anna M. Puzio-Kuter, Chris Mulligan, Brandon Russo, Amy Wiebesiek, Lizhong Xu, Hong Yang, Binh Vu, Melissa Dumble
Publikováno v:
Cancer Research. 82:1295-1295
Half of human cancers possess mutations in the TP53 gene, with most clustering as hotspots in the DNA binding domain. A tyrosine to cysteine substitution at amino acid 220 of the p53 protein (Y220C) is one such hotspot mutation (~1% of all solid tumo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b567661855b57c06f9fae6bd939fc4e
https://doi.org/10.1158/1538-7445.am2022-1295
https://doi.org/10.1158/1538-7445.am2022-1295
Autor:
Ecaterina Elena Dumbrava, Melissa Lynne Johnson, Anthony W. Tolcher, Geoffrey Shapiro, John A. Thompson, Anthony B. El-Khoueiry, Andrae Lavon Vandross, Shivaani Kummar, Aparna Raj Parikh, Pamela N. Munster, Erika Daly, Laura De Leon, Megan Khaddar, Kimberley LeDuke, Kimberly Robell, Lisa Iacono Sheehan, Meagen St. Louis, Amy Wiebesiek, Leila Alland, Alison M. Schram
Publikováno v:
Journal of Clinical Oncology. 40:3003-3003
3003 Background: The p53 tumor suppressor protein is a transcription factor that acts to maintain genome stability in response to cellular stress. Spontaneous mutation of the TP53 gene leading to inactivation of the p53 protein is the most common mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c378fbe63b697c4e9b8c0762d21af7a
https://doi.org/10.1200/jco.2022.40.16_suppl.3003
https://doi.org/10.1200/jco.2022.40.16_suppl.3003
Autor:
Kelly McGlinchey, Mei-Li Wen, Robert M. Townsend, Rosemary Zhang, Gary L. Schieven, Amy Wiebesiek, Krista Menard, Richard Smykla, Sidney Pitt, Francis Y. Lee, Vojkan Susulic
Publikováno v:
Blood. 114:2198-2198
Abstract 2198 Poster Board II-175 Dasatinib (SPRYCEL®), a small molecule tyrosine kinase inhibitor is 325-fold more potent against BCR-ABL than imatinib. Targeting BCR-ABL in chronic myeloid leukemia (CML), dasatinib offers the most favorable benefi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8bc6d31b2c8b2db7771e1855e06f0a2
https://doi.org/10.1182/blood.v114.22.2198.2198
https://doi.org/10.1182/blood.v114.22.2198.2198
Autor:
Gregory D. Vite, Richard Smykla, Krista Menard, Amy Wiebesiek, Francis Y. Lee, Kathy A. Johnston, Robert Kramer, Craig R. Fairchild, Kelly McGlinchey, Russell Peterson
Publikováno v:
Cancer Chemotherapy and Pharmacology. 63(2):201-212
Ixabepilone, a semisynthetic analog of natural epothilone B, was developed for use in cancer treatment. This study extends previous findings regarding the efficacy of ixabepilone and its low susceptibility to tumor resistance mechanisms and describes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcaafabc188fb5d55c44c15477a448b5