Výsledky vyhledávání - "Amy Wanamaker"

Akademický článek

364 A personal neoantigen vaccine NEO-PV-01 in combination with chemotherapy and pembrolizumab induces broad de novo immune responses in first line, non-squamous NSCLC

Autor: Saiama Waqar, Mark Awad, Ramaswamy Govindan, David Spigel, Richard Gaynor, Edward Garon, Aaron Lisberg, Melissa Moles, Jennifer Tepper, April Lamb, Amy Wanamaker, Zakaria Khondker, John Srouji, Jesse Dong, Asaf Poran, Kristen Balogh, Meghan Bushway, Mark DeMario, Lakshmi Srinivasan

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Externí odkaz: https://doaj.org/article/87f0b6347d22484b87bc7e8bf04d1d1e

Zobrazit plný text záznamu

364 A personal neoantigen vaccine NEO-PV-01 in combination with chemotherapy and pembrolizumab induces broad de novo immune responses in first line, non-squamous NSCLC

Autor: Meghan E. Bushway, Melissa A. Moles, Amy Wanamaker, Zakaria S. Khondker, Mark DeMario, David R. Spigel, Jennifer Tepper, Mark Awad, Ramaswamy Govindan, Saiama N. Waqar, Kristen N. Balogh, Asaf Poran, Richard B. Gaynor, Edward B. Garon, Jesse Z. Dong, Aaron Lisberg, Lakshmi Srinivasan, April Lamb, John Srouji

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)

Background Neoantigens arising from mutations in cancer cell DNA are important targets for T cell mediated anti-tumor immunity. NEO-PV-01 is a personal neoantigen vaccine of up to 20 peptides (14–35 amino acids) based on a patient‘s HLA profile a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c2b26d52ca49422c84c0b2a2796bf4
https://doaj.org/article/87f0b6347d22484b87bc7e8bf04d1d1e

Zobrazit plný text záznamu

Combined TCR Repertoire Profiles and Blood Cell Phenotypes Predict Melanoma Patient Response to Personalized Neoantigen Therapy plus Anti-PD-1

Autor: Meghan E. Bushway, Kristen N. Balogh, Lakshmi Srinivasan, Zakaria S. Khondker, Patrick A. Ott, Rana H. Besada, Richard B. Gaynor, Julian Scherer, Jasmina Prabhakara, Siwen Hu-Lieskovan, Michael S. Rooney, Reid G. Williams, Amy Wanamaker, Asaf Poran

Publikováno v: Cell Reports Medicine

Summary T cells use highly diverse receptors (TCRs) to identify tumor cells presenting neoantigens arising from genetic mutations and establish anti-tumor activity. Immunotherapy harnessing neoantigen-specific T cells to target tumors has emerged as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454be1df2b0d61360ad4496862fe793c
https://pubmed.ncbi.nlm.nih.gov/33294862

Zobrazit plný text záznamu

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

Publikováno v: Cell. 183(2)

Summary Neoantigens arise from mutations in cancer cells and are important targets of T cell-mediated anti-tumor immunity. Here, we report the first open-label, phase Ib clinical trial of a personalized neoantigen-based vaccine, NEO-PV-01, in combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515738446c00429f62713aedbb493a4c
https://pubmed.ncbi.nlm.nih.gov/34781699

Zobrazit plný text záznamu

Abstract 73: A personal neoantigen vaccine NEO-PV-01 in combination with chemotherapy and pembrolizumab induces broad de novo immune responses in first-line non-squamous NSCLC: Associations with clinical outcomes

Publikováno v: Cancer Research. 81:73-73

Background: Neoantigens arising from mutations in cancer cell DNA are important targets for T cell-mediated anti-tumor immunity. NEO-PV-01 is a personal neoantigen vaccine of up to 20 peptides (14-35 amino acids) based on a patient's HLA profile and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd7af39f7b55e8dc605d911f86a4231c
https://doi.org/10.1158/1538-7445.am2021-73

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání