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pro vyhledávání: '"Amy S. Warwick"'
Autor:
Jessica S. Ebo, Janet C. Saunders, Paul W. A. Devine, Alice M. Gordon, Amy S. Warwick, Bob Schiffrin, Stacey E. Chin, Elizabeth England, James D. Button, Christopher Lloyd, Nicholas J. Bond, Alison E. Ashcroft, Sheena E. Radford, David C. Lowe, David J. Brockwell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Protein aggregation remains a significant challenge for manufacturing of protein biopharmaceuticals. Here, the authors demonstrate the use of directed evolution and an assay for in vivo innate protein aggregation-propensity to generate aggregation-re
Externí odkaz:
https://doaj.org/article/7cd4d27ccee2435a841e247a296e334c
Autor:
Paul W. A. Devine, Elizabeth England, Nicholas J. Bond, David C. Lowe, Amy S. Warwick, James Button, Sheena E. Radford, Janet C. Saunders, Bob Schiffrin, Alison E. Ashcroft, Alice M. Gordon, Chris Lloyd, David J. Brockwell, Stacey E. Chin, Jessica S. Ebo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Protein biopharmaceuticals are highly successful, but their utility is compromised by their propensity to aggregate during manufacture and storage. As aggregation can be triggered by non-native states, whose population is not necessarily related to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96889bc4c8d3d6996481b717209e811e
https://doaj.org/article/7cd4d27ccee2435a841e247a296e334c
https://doaj.org/article/7cd4d27ccee2435a841e247a296e334c