Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Amy S. Kenyon"'
Autor:
Emilio F. Stuart, Nick Clarke, Paul Alan Glossop, Neil Feeder, Strang Ross Sinclair, J. W. Watson, Jane L. Burrows, Amy S. Kenyon, Matthew D. Selby, Michael A. Trevethick, Sheena Patel, Rhys M. Jones, Kim James, Karen N. Wright, Dannielle Frances Roberts, Lyn H. Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5121-5126
A 1,2,4-triazole motif was employed as a bioisostere for the ester commonly used in muscarinic antagonists, and subsequent integrative conjugation to a β2 agonist quinolinone furnished a new class of bifunctional MABAs for the treatment of COPD. Med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b09018de8f7e915b91637ee9153193
https://doi.org/10.1016/j.bmcl.2015.10.008
https://doi.org/10.1016/j.bmcl.2015.10.008
Autor:
Andrews Mark David, Robert M. Owen, Mathilde Grenie, Kevin Beaumont, David C. Pryde, Sebastien Galan, Dannielle Frances Roberts, Tram T. Tran, Paul Alan Glossop, Amy S. Kenyon, Graham Lunn, Alan S. Jessiman, Maw Graham Nigel, Kerry af Forselles
Publikováno v:
ACS Medicinal Chemistry Letters. 6:419-424
The transient receptor potential (TRP) family of ion channels comprises nonselective cation channels that respond to a wide range of chemical and thermal stimuli. TRPM8, a member of the melastatin subfamily, is activated by cold temperatures (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::941a1288871b774cfd5c8457ad7fad19
https://doi.org/10.1021/ml500479v
https://doi.org/10.1021/ml500479v
Autor:
Paul Alan Glossop, Susan Summerhill, Hao Liu, Sheena Patel, Lyn H. Jones, Nick Clarke, Amy S. Kenyon, Rachel Osborne
Publikováno v:
Journal of Medicinal Chemistry. 54:6998-7002
Following interrogation of a wide-ligand profile database, a nonselective norepinephrin reuptake inhibitor was converted into a novel muscarinic antagonist using two medicinal chemistry transformations (M3/NRI selectivity of >1000). Conjugation to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7583d1241fdf5a93ebc8010c3725cc83
https://doi.org/10.1021/jm2007535
https://doi.org/10.1021/jm2007535
Autor:
Craig K. Fulton, David Price, Kim James, Mark E. Bunnage, Sandra D. Newman, Sheena Patel, Jane L. Burrows, Emilio F. Stuart, Rachel Osborne, Stuart Marshall, Nick Clarke, Matthew D. Selby, Neil Feeder, David A. Entwistle, Helen Baldock, Rhys M. Jones, Michele Coghlan, Laura Hilton, Michael A. Trevethick, Karen N. Wright, David Fairman, Lyn H. Jones, Amy S. Kenyon
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
This paper describes the successful design and development of dual pharmacology β-2 agonists-M3 antagonists, for the treatment of chronic obstructive pulmonary disorder using the principles of 'inhalation by design'. A key feature of this work is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf2972c74e7582b1b629c2304ccadb40
https://pubmed.ncbi.nlm.nih.gov/21075627
https://pubmed.ncbi.nlm.nih.gov/21075627
Optimized glucuronidation of dual pharmacology β-2 agonists/M3 antagonists for the treatment of COPD
Autor:
Rachel Osborne, David A. Entwistle, Michael Yeadon, Graham Lunn, Karen N. Wright, Jane L. Burrows, Emilio F. Stuart, Lyn H. Jones, Sandra D. Newman, Kim James, Amy S. Kenyon, Fiona J. Spence, Susan Summerhill, Matthew D. Selby, Nick Clarke, David Price, Stuart Marshall, Laura Hilton, Helen Baldock, Rhys M. Jones, Neil Feeder, Michael A. Trevethick, Sheena Patel, Nadia Laouar, Michele Coghlan, Mark E. Bunnage, David Fairman
Publikováno v:
MedChemComm. 2:870
‘Inhalation by design’ concepts were developed to create novel dual pharmacology β-2 agonists-M3 antagonists, for the treatment of chronic obstructive pulmonary disorder. A key feature of this work is the combination of balanced potency and phar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8e88fd334de3783a85ab6566fddbc69
https://doi.org/10.1039/c1md00140j
https://doi.org/10.1039/c1md00140j