Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Amy S. Guala"'
Autor:
Amy S. Guala, James D. Nolin, Jos van der Velden, Jane E. Tully, Matthew E. Poynter, Albert van der Vliet, Yvonne M. W. Janssen-Heininger, Sidra M. Hoffman, Vikas Anathy
Publikováno v:
Free Radical Biology and Medicine. 73:143-153
Interleukin-17A (IL-17A) is a newly emerging player in the pathogenesis of chronic lung diseases that amplifies inflammatory responses and promotes tissue remodeling. Stimulation of lung epithelial cells with IL-17A leads to activation of the transcr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e226784082b07f8fc71984b61ecccc3
https://doi.org/10.1016/j.freeradbiomed.2014.04.028
https://doi.org/10.1016/j.freeradbiomed.2014.04.028
Autor:
Matthew J. Wargo, Laurie W Leclair, Scott W. Aesif, Yvonne M. W. Janssen-Heininger, Vikas Anathy, Sidra M. Hoffman, Karolyn G. Lahue, Amy S. Guala, Carlyne D. Cool, Jenna Bement, Benjamin T. Suratt
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 189:463-474
The death receptor Fas is critical for bacterial clearance and survival of mice after Pseudomonas aeruginosa infection.Fas ligand (FasL)-induced apoptosis is augmented by S-glutathionylation of Fas (Fas-SSG), which can be reversed by glutaredoxin-1 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d278b6d2ed6756889507444219922f
https://doi.org/10.1164/rccm.201310-1905oc
https://doi.org/10.1164/rccm.201310-1905oc
Autor:
Susan E. Leggett, Yvonne M. W. Janssen-Heininger, Amy S. Guala, Jasper Sluimer, Elsbeth C. H. L. Badura, Jos van der Velden
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 47:306-314
Recent studies suggest the importance of the transition of airway epithelial cells (EMT) in pulmonary fibrosis, and also indicate a role for Wingless protein (Wnt)/β-catenin signaling in idiopathic pulmonary fibrosis. We investigated the possible ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab59fe95dfb2210da9516a975302972
https://doi.org/10.1165/rcmb.2011-0297oc
https://doi.org/10.1165/rcmb.2011-0297oc
Autor:
Karolyn E. Godburn, Oliver Dienz, Yvonne M. W. Janssen-Heininger, Amy S. Guala, David W. H. Riches, Vikas Anathy, Derek Pociask, Elle C. Roberson, Jane E. Tully, John F. Alcorn, Jessica N. Reiss
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 46:573-581
Influenza A virus (IAV) infection is known to induce endoplasmic reticulum (ER) stress, Fas-dependent apoptosis, and TGF-β production in a variety of cells. However, the relationship between these events in murine primary tracheal epithelial cells (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f825d1805908e2f53201bdf80d9364c
https://doi.org/10.1165/rcmb.2010-0460oc
https://doi.org/10.1165/rcmb.2010-0460oc
Autor:
Karolyn E. Godburn, Vikas Anathy, Amy S. Guala, Yvonne M. W. Janssen-Heininger, Elle C. Roberson, Ralph C. Budd
Publikováno v:
Antioxidants & Redox Signaling. 16:496-505
Significance: Redox-based signaling governs a number of important pathways in tissue homeostasis. Consequently, deregulation of redox-controlled processes has been linked to a number of human diseases. Among the biological processes regulated by redo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::848b3746ecac01c870f1f63ce492d0c9
https://doi.org/10.1089/ars.2011.4281
https://doi.org/10.1089/ars.2011.4281
Autor:
Amy S. Guala, Freek G. Bouwman, Niki L. Reynaert, Edwin C. M. Mariman, Gonda Konings, Ine Kuipers, Emiel F.M. Wouters, Yvonne M. W. Janssen-Heininger, Scott W. Aesif
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology, 45(5), 931-937. American Thoracic Society
It is established that cigarette smoke causes irreversible oxidations in lung epithelial cells and can lead to their death. However, its impact on reversible and physiologically relevant redox-dependent protein modifications remains to be investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcab36c509005d84f3124dac6ff76dc5
https://doi.org/10.1165/rcmb.2010-0249OC
https://doi.org/10.1165/rcmb.2010-0249OC
Autor:
Yvonne M. W. Janssen-Heininger, Scott W. Aesif, Jessica N. Reiss, Ine Kuipers, Amy S. Guala, Ye-Shih Ho, Vikas Anathy
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology, 44(4), 491-499. American Thoracic Society
Protein S-glutathionylation (PSSG), a reversible posttranslational modification of reactive cysteines, recently emerged as a regulatory mechanism that affects diverse cell-signaling cascades. The extent of cellular PSSG is controlled by the oxidoredu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330143955bedb7309963f87ba99d737a
https://doi.org/10.1165/rcmb.2009-0136oc
https://doi.org/10.1165/rcmb.2009-0136oc
Autor:
Yvonne M. W. Janssen-Heininger, John F. Alcorn, Amy S. Guala, Elsbeth C. H. L. Badura, Jos van der Velden
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 44:571-581
Transforming growth factor (TGF)–β1 is a key mediator of lung remodeling and fibrosis. Epithelial cells are both a source of and can respond to TGF-β1 with epithelial-to-mesenchymal transition (EMT). We recently determined that TGF-β1–induced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01d4139a49713717abcebc570352374
https://doi.org/10.1165/rcmb.2009-0282oc
https://doi.org/10.1165/rcmb.2009-0282oc
Autor:
Ralph C. Budd, Scott W. Aesif, Niki L. Reynaert, Jos van der Velden, Vikas Anathy, Yvonne M. W. Janssen-Heininger, Elle C. Roberson, Jessica N. Reiss, Amy S. Guala
Publikováno v:
Annals of the New York Academy of Sciences. 1203:23-28
Tissue fibrosis is believed to be a manifestation of dysregulated repair following injury, in association with impaired reepithelialization, and aberrant myofibroblast activation and proliferation. Numerous pathways have been linked to the pathogenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51bb7b023920fbc9cee90595f282736f
https://doi.org/10.1111/j.1749-6632.2010.05553.x
https://doi.org/10.1111/j.1749-6632.2010.05553.x
Autor:
Charles G. Irvin, Jay K. Kolls, Amy S. Guala, Albert van der Vliet, Amy L. Brown, Matthew E. Poynter, John F. Alcorn, Yvonne M. W. Janssen-Heininger, Karina Ckless
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 298:L57-L66
NF-κB activation in the airway epithelium has been established as a critical pathway in ovalbumin (Ova)-induced airway inflammation in BALB/c mice (Poynter ME, Cloots R, van Woerkom T, Butnor KJ, Vacek P, Taatjes DJ, Irvin CG, Janssen-Heininger YM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87cd38200ff61b1701c2c9336ad8371a
https://doi.org/10.1152/ajplung.00037.2009
https://doi.org/10.1152/ajplung.00037.2009