Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Amy R. Sanguinetti"'
1
Mechanism of the Inhibition of Ca2+-Activated Cl− Currents by Phosphorylation in Pulmonary Arterial Smooth Muscle Cells
Autor: Jeff E. Angermann, Normand Leblanc, James L. Kenyon, Amy R. Sanguinetti, Iain A. Greenwood
Publikováno v: The Journal of General Physiology
The aim of the present study was to provide a mechanistic insight into how phosphatase activity influences calcium-activated chloride channels in rabbit pulmonary artery myocytes. Calcium-dependent Cl- currents (I(ClCa)) were evoked by pipette soluti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2f5aaa377a1e9fe02274d79ce93e6b
https://doi.org/10.1085/jgp.200609507
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3
Regulation of calcium-activated chloride channels in smooth muscle cells: a complex picture is emerging
Autor: Iain A. Greenwood, Kate E O'Driscoll, Amy R. Sanguinetti, Sohag N. Saleh, Jonathan Ledoux, Jeff E. Angermann, Brian A. Perrino, Normand Leblanc, Fiona C. Britton
Publikováno v: Canadian Journal of Physiology and Pharmacology. 83:541-556
Calcium-activated chloride channels (ClCa) are ligand-gated anion channels as they have been shown to be activated by a rise in intracellular Ca2+concentration in various cell types including cardiac, skeletal and vascular smooth muscle cells, endoth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d53f654ab2058267a0e037d90be8ca5
https://doi.org/10.1139/y05-040
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4
c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14
Autor: Cynthia Corley Mastick, Amy R. Sanguinetti
Publikováno v: Cellular Signalling. 15:289-298
Caveolin-1 is phosphorylated at tyrosine 14 in response to cellular stress. Tyrosine 14 is a consensus Abl phosphorylation site suggesting that caveolin-1 may be an Abl substrate. We report here that expression of c-Abl is required for oxidative stre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2e10dced0a272f302475bae456b35d
https://doi.org/10.1016/s0898-6568(02)00090-6
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5
Complex Phosphatase Regulation of Ca2+-activated Cl− Currents in Pulmonary Arterial Smooth Muscle Cells*
Autor: Michael Wiwchar, Ramon J. Ayon, Iain A. Greenwood, Amy R. Sanguinetti, Maria L. Valencik, William Sones, Abigail S. Forrest, Normand Leblanc, Brian A. Perrino
The present study was undertaken to determine whether the two ubiquitously expressed Ca(2+)-independent phosphatases PP1 and PP2A regulate Ca(2+)-activated Cl(-) currents (I(Cl(Ca))) elicited by 500 nM [Ca(2+)](i) in rabbit pulmonary artery (PA) myoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f7bf791353e80cee2abb63ed920a35d
https://europepmc.org/articles/PMC2781665/
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8
c-Abl is required for staurosporine-induced caspase activity
Autor: Brian C, Oxhorn, Amy R, Sanguinetti, Cynthia Corley, Mastick, Iain L O, Buxton
Publikováno v: Proceedings of the Western Pharmacology Society. 48
Caspases are the intracellular molecular machinery responsible for apoptotic cell death. The regulation of these critical proteolytic enzymes is known to occur on multiple levels. While their expression as inactive precursors exhibits a primary level
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::91a8d10a9ed1d9fc284d1fe4388cda19
https://pubmed.ncbi.nlm.nih.gov/16416674
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9
Calcineurin Aalpha but not Abeta augments ICl(Ca) in rabbit pulmonary artery smooth muscle cells
Autor: Iain A. Greenwood, Amy R. Sanguinetti, Brian A. Perrino, Normand Leblanc, Jonathan Ledoux
Publikováno v: The Journal of biological chemistry. 279(37)
Activation of Ca(2+)-dependent Cl(-) currents (I(Cl(Ca))) increases membrane excitability in vascular smooth muscle cells. Previous studies showed that Ca(2+)-dependent phosphorylation suppresses I(Cl(Ca)) in pulmonary artery myocytes, and the aim of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc57f5cf76d50d274a8056dbbb1c0213
https://pubmed.ncbi.nlm.nih.gov/15247251
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10
Fyn is required for oxidative- and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1
Autor: Cynthia Corley Mastick, Amy R. Sanguinetti, Haiming Cao
Caveolin-1 is phosphorylated on Tyr14 in response to both oxidative and hyperosmotic stress. In the present paper, we show that this phosphorylation requires activation of the Src family kinase Fyn. Stress-induced caveolin phosphorylation was abolish
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::532403878a4d8e2cb4bc606a48dc0952
https://europepmc.org/articles/PMC1223754/
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