Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Amy R Howell"'
Autor:
Gabriel Bricard, Manjunatha M Venkataswamy, Karl O A Yu, Jin S Im, Rachel M Ndonye, Amy R Howell, Natacha Veerapen, Petr A Illarionov, Gurdyal S Besra, Qian Li, Young-Tae Chang, Steven A Porcelli
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14374 (2010)
CD1d-restricted natural killer T cells with invariant T cell receptor α chains (iNKT cells) are a unique lymphocyte subset that responds to recognition of specific lipid and glycolipid antigens. They are conserved between mice and humans and exert v
Externí odkaz:
https://doaj.org/article/30a81dbcdd4a47488296dc3507415353
Autor:
Lisa M Fox, Daryl G Cox, Jennifer L Lockridge, Xiaohua Wang, Xiuxu Chen, Louise Scharf, David L Trott, Rachel M Ndonye, Natacha Veerapen, Gurdyal S Besra, Amy R Howell, Mark E Cook, Erin J Adams, William H Hildebrand, Jenny E Gumperz
Publikováno v:
PLoS Biology, Vol 7, Iss 10, p e1000228 (2009)
Natural killer T (NKT) cells are a subset of T lymphocytes with potent immunoregulatory properties. Recognition of self-antigens presented by CD1d molecules is an important route of NKT cell activation; however, the molecular identity of specific aut
Externí odkaz:
https://doaj.org/article/3f5a22c8a7f44061b89d85e01ac33a7a
Autor:
Noemi Alejandra Saavedra-Avila, Paolo Dellabona, Giulia Casorati, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Steven A. Porcelli
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Invariant natural killer T (iNKT) cells mediate immune responses when stimulated by glycolipid agonists presented by CD1d. In extensive studies of synthetic analogues of α-galactosyl ceramides, we identified numerous examples of significant differen
Externí odkaz:
https://doaj.org/article/5d32e342b826403ea225e6efd39248ae
Autor:
Amanda Long, Anagha Inguva, Marina Predovic, Jarrett R. Remsberg, Thomas W. Hanigan, Stewart K. Richardson, Noemi A. Zambetti, Micah J. Niphakis, Nhi Ngo, Amy R. Howell, Cassandra L. Henry, Ari J. Firestone, Benjamin F. Cravatt, Kenneth M. Lum, Ben Huang, Kevin Shannon, Radu M. Suciu, Melissa M. Dix
Publikováno v:
Nature chemical biology, vol 17, iss 8
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but lack spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b253176c07cc9e4d8c9643b76bcc8a6
https://doi.org/10.1038/s41589-021-00785-8
https://doi.org/10.1038/s41589-021-00785-8
Publikováno v:
Chemical Science
The first general preparation of 4-bromo-2,3-dihydrofurans is reported. These non-aromatic heterocycles containing a useful coupling handle are accessed via Cu-catalyzed intramolecular cyclization of 1,2-dibromohomoallylic alcohols, which are themsel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9875ab2e9ac36fc92fb62d9232be39
https://doi.org/10.1039/d1sc01013a
https://doi.org/10.1039/d1sc01013a
Autor:
Lawrence K. Silbart, Michael A. Lynes, Gregory P. Marusov, John Zinckgraf, Stewart K. Richardson, Debra Rood, Daniel I. Zapata, Amy R. Howell, Tolga Barker, Heather Wanczyk
Publikováno v:
Toxins, Vol 5, Iss 3, Pp 568-589 (2013)
Smokeless tobacco products have been associated with increased risks of oro-pharyngeal cancers, due in part to the presence of tobacco-specific nitrosamines (TSNAs) such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). These potent carcinogen
Externí odkaz:
https://doaj.org/article/949b583833534852a086a495af76dde4
Autor:
José A. Gascón, Noemi Alejandra Saavedra-Avila, Carolina Schäfer, Matthew J. Guberman-Pfeffer, Santosh Keshipeddy, Amy R. Howell, Ayax Pérez-Gallegos, Leandro J. Carreño, Neeraj K. Saini, Steven A. Porcelli
Publikováno v:
ACS Chem Biol
Activation of invariant natural killer T (iNKT) cells by α-galactosylceramides (α-GalCers) stimulates strong immune responses and potent anti-tumor immunity. Numerous modifications of the glycolipid structure have been assessed to derive activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e296c53b1a3d36af491e15cba0561ccc
https://doi.org/10.1021/acschembio.0c00707
https://doi.org/10.1021/acschembio.0c00707
Autor:
Ping Xiang, Narayanaswamy Venketasubramanian, Joyce R. Chong, Amy R. Howell, Kaddy Camara, Federico Torta, Christopher P Chen, Xin Ying Chua, Deron R. Herr, Markus R. Wenk, Hui Li Ang, Yuek Ling Chai, Mitchell K.P. Lai, Wee Siong Chew, Saima Hilal
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Background There has been ongoing research impetus to uncover novel blood-based diagnostic and prognostic biomarkers for Alzheimer’s disease (AD), vascular dementia (VaD), and related cerebrovascular disease (CEVD)-associated conditions within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6acb66d31835e8e0494e286c6b3a6d
http://link.springer.com/article/10.1186/s13195-020-00694-3
http://link.springer.com/article/10.1186/s13195-020-00694-3
Publikováno v:
Accounts of chemical research. 54(20)
Oxetanes are important motifs for drug discovery and are valuable templates in organic synthesis. Much of their use as synthetic intermediates exploits their inherent strain, often resulting in chain extensions at the expense of the heterocycle. Modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d24cb38c2d58994d82fa174df019d2
https://pubmed.ncbi.nlm.nih.gov/34592094
https://pubmed.ncbi.nlm.nih.gov/34592094
Autor:
Chulangani Weerasooriya, Radu M. Suciu, Benjamin F. Cravatt, Irungu K. Luvaga, Amy R. Howell, Ari J. Firestone, Kevin Shannon, Akram Hazeen, Stewart K. Richardson
Publikováno v:
Bioorg Med Chem Lett
S-Palmitoylation is a reversible post-translational lipid modification that regulates protein trafficking and signaling. The enzymatic depalmitoylation of proteins is inhibited by the beta-lactones Palmostatin M and B, which have been found to target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e9ac03654985dce671c0afb03b13aa
https://pubmed.ncbi.nlm.nih.gov/34666187
https://pubmed.ncbi.nlm.nih.gov/34666187