Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Amy R Howell"'
Autor:
Noemi Alejandra Saavedra-Avila, Paolo Dellabona, Giulia Casorati, Natacha Veerapen, Gurdyal S. Besra, Amy R. Howell, Steven A. Porcelli
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Invariant natural killer T (iNKT) cells mediate immune responses when stimulated by glycolipid agonists presented by CD1d. In extensive studies of synthetic analogues of α-galactosyl ceramides, we identified numerous examples of significant differen
Externí odkaz:
https://doaj.org/article/5d32e342b826403ea225e6efd39248ae
Autor:
Xin Ying Chua, Yuek Ling Chai, Wee Siong Chew, Joyce R. Chong, Hui Li Ang, Ping Xiang, Kaddy Camara, Amy R. Howell, Federico Torta, Markus R. Wenk, Saima Hilal, Narayanaswamy Venketasubramanian, Christopher P. Chen, Deron R. Herr, Mitchell K. P. Lai
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-12 (2020)
Abstract Background There has been ongoing research impetus to uncover novel blood-based diagnostic and prognostic biomarkers for Alzheimer’s disease (AD), vascular dementia (VaD), and related cerebrovascular disease (CEVD)-associated conditions wi
Externí odkaz:
https://doaj.org/article/318c95efb1554616839ef2f7287fa803
Autor:
Shilpi Chandra, James Gray, William B. Kiosses, Archana Khurana, Kaori Hitomi, Catherine M. Crosby, Ashu Chawla, Zheng Fu, Meng Zhao, Natacha Veerapen, Stewart K. Richardson, Steven A. Porcelli, Gurdyal Besra, Amy R. Howell, Sonia Sharma, Bjoern Peters, Mitchell Kronenberg
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activatio
Externí odkaz:
https://doaj.org/article/4dce5c3c771f4a1abdb502245e1a6bb5
Autor:
Sourav Biswas, Harshul S. Khanna, Quddus A. Nizami, Donald R. Caldwell, Katherine T. Cavanaugh, Amy R. Howell, Sumathy Raman, Steven L. Suib, Partha Nandi
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Herein, we report a one-step peroxide mediated heterogeneous catalytic oxidation of amides to imides utilizing a series of manganese oxides. Among them, Cs/Mn2O3 was found to be the most active catalyst for the selective partial oxidation of
Externí odkaz:
https://doaj.org/article/88c076a7233e4b528f60fabbe04fa910
Autor:
Jérôme Le Nours, T. Praveena, Daniel G. Pellicci, Nicholas A. Gherardin, Fiona J. Ross, Ricky T. Lim, Gurdyal S. Besra, Santosh Keshipeddy, Stewart K. Richardson, Amy R. Howell, Stephanie Gras, Dale I. Godfrey, Jamie Rossjohn, Adam P. Uldrich
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus
Externí odkaz:
https://doaj.org/article/19f35c34e90047c3a1089ce7f064778b
Publikováno v:
Molecules, Vol 19, Iss 7, Pp 10090-10102 (2014)
Structural studies of ternary complexes of CD1d/glycosyl ceramides/iNKT cells and CD1d/sulfatide/sulfatide reactive Type II NKT cells have shown how the polar moieties on the glycolipids interact with both the antigen presenting protein (CD1d) and th
Externí odkaz:
https://doaj.org/article/c8306100646d4f168884eaa4d1396ab6
Autor:
Amanda Long, Anagha Inguva, Marina Predovic, Jarrett R. Remsberg, Thomas W. Hanigan, Stewart K. Richardson, Noemi A. Zambetti, Micah J. Niphakis, Nhi Ngo, Amy R. Howell, Cassandra L. Henry, Ari J. Firestone, Benjamin F. Cravatt, Kenneth M. Lum, Ben Huang, Kevin Shannon, Radu M. Suciu, Melissa M. Dix
Publikováno v:
Nature chemical biology, vol 17, iss 8
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but lack spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b253176c07cc9e4d8c9643b76bcc8a6
https://doi.org/10.1038/s41589-021-00785-8
https://doi.org/10.1038/s41589-021-00785-8
Publikováno v:
Chemical Science
The first general preparation of 4-bromo-2,3-dihydrofurans is reported. These non-aromatic heterocycles containing a useful coupling handle are accessed via Cu-catalyzed intramolecular cyclization of 1,2-dibromohomoallylic alcohols, which are themsel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9875ab2e9ac36fc92fb62d9232be39
https://doi.org/10.1039/d1sc01013a
https://doi.org/10.1039/d1sc01013a
Autor:
Lawrence K. Silbart, Michael A. Lynes, Gregory P. Marusov, John Zinckgraf, Stewart K. Richardson, Debra Rood, Daniel I. Zapata, Amy R. Howell, Tolga Barker, Heather Wanczyk
Publikováno v:
Toxins, Vol 5, Iss 3, Pp 568-589 (2013)
Smokeless tobacco products have been associated with increased risks of oro-pharyngeal cancers, due in part to the presence of tobacco-specific nitrosamines (TSNAs) such as 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). These potent carcinogen
Externí odkaz:
https://doaj.org/article/949b583833534852a086a495af76dde4
Autor:
José A. Gascón, Noemi Alejandra Saavedra-Avila, Carolina Schäfer, Matthew J. Guberman-Pfeffer, Santosh Keshipeddy, Amy R. Howell, Ayax Pérez-Gallegos, Leandro J. Carreño, Neeraj K. Saini, Steven A. Porcelli
Publikováno v:
ACS Chem Biol
Activation of invariant natural killer T (iNKT) cells by α-galactosylceramides (α-GalCers) stimulates strong immune responses and potent anti-tumor immunity. Numerous modifications of the glycolipid structure have been assessed to derive activating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e296c53b1a3d36af491e15cba0561ccc
https://doi.org/10.1021/acschembio.0c00707
https://doi.org/10.1021/acschembio.0c00707