Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Amy R Fairchild"'
Autor:
Yura Grabovska, Alan Mackay, Patricia O’Hare, Stephen Crosier, Martina Finetti, Edward C. Schwalbe, Jessica C. Pickles, Amy R. Fairchild, Aimee Avery, Julia Cockle, Rebecca Hill, Janet Lindsey, Debbie Hicks, Mark Kristiansen, Jane Chalker, John Anderson, Darren Hargrave, Thomas S. Jacques, Karin Straathof, Simon Bailey, Chris Jones, Steven C. Clifford, Daniel Williamson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Here, using methylCIBERSORT, the authors characterize the tumour-immune microenvironment of paediatric central nervous system (CNS) tumours and its association with tumour type and prognosis. These findings suggest that immuno-methylomic profiling ma
Externí odkaz:
https://doaj.org/article/ec15b2c4e08f447294d1c85b886169aa
Autor:
Chris Jones, Darren Hargrave, Michael Hubank, Simon P. Robinson, Maria Vinci, Jacques Grill, Fernando Carceller, Lynley V. Marshall, Bassel Zebian, Juliet C. Gray, Shaun Wilson, Jenny Adamski, Susan Picton, Lisa Howell, Richard G. Grundy, Thomas S. Jacques, Amy R. Fairchild, Matthew Clarke, Jyoti S. Choudhary, Georgia Roumelioti, Lu Yu, Patricia O'Hare, Sarita Depani, Mark Stubbs, Paula Z. Proszek, Maria Antonietta Ajmone-Cat, Rebecca F. Rogers, Yura Grabovska, Valeria Molinari, Molina Das, Elisabet Fernandez, Giulia Pericoli, Jessica K.R. Boult, Sara Temelso, Alan Mackay, Diana M. Carvalho, Elisa Izquierdo
Supplementary Data from DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e517467233a2c87a6f6d3fca76fd19
https://doi.org/10.1158/2159-8290.22541540
https://doi.org/10.1158/2159-8290.22541540
Autor:
Chris Jones, Darren Hargrave, Michael Hubank, Simon P. Robinson, Maria Vinci, Jacques Grill, Fernando Carceller, Lynley V. Marshall, Bassel Zebian, Juliet C. Gray, Shaun Wilson, Jenny Adamski, Susan Picton, Lisa Howell, Richard G. Grundy, Thomas S. Jacques, Amy R. Fairchild, Matthew Clarke, Jyoti S. Choudhary, Georgia Roumelioti, Lu Yu, Patricia O'Hare, Sarita Depani, Mark Stubbs, Paula Z. Proszek, Maria Antonietta Ajmone-Cat, Rebecca F. Rogers, Yura Grabovska, Valeria Molinari, Molina Das, Elisabet Fernandez, Giulia Pericoli, Jessica K.R. Boult, Sara Temelso, Alan Mackay, Diana M. Carvalho, Elisa Izquierdo
The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In a prospective biopsy-stratified clinical trial, we combined detailed molecular profiling and drug screening in newly esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::102dde0a334f478c2a9989b6c517af6d
https://doi.org/10.1158/2159-8290.c.6549665
https://doi.org/10.1158/2159-8290.c.6549665
Autor:
Chris Jones, David T.W. Jones, Thomas S. Jacques, David W. Ellison, Sergey Popov, David Capper, Maria Vinci, Andrea Carai, Angela Mastronuzzi, Suzanne J. Baker, Felix Sahm, Stefan M. Pfister, Christof M. Kramm, Andreas von Deimling, Lynley V. Marshall, Fernando Carceller, Darren R. Hargrave, Kristian Aquilina, Matthias A. Karajannis, David S. Ziegler, Mark J. Cowley, Maria Tsoli, Stephen P. Lowis, Timothy E.G. Hassall, Andrew S. Moore, Simon Bailey, Francesca Diomedi-Camassei, Giovanna Stefania Colafati, Evelina Miele, Clare Mitchell, Tabitha Bloom, Olaf Witt, Marc Zuckermann, Dominik Sturm, Barbara C. Worst, Lotte Hiddingh, Andrey Korshunov, Pablo Hernáiz Driever, Felipe Andreiuolo, Torsten Pietsch, Simone Hettmer, Kornelius Kerl, Winand N.M. Dinjens, Martin Ebinger, Martin U. Schuhmann, Jens Schittenhelm, Michael Karremann, Michael Capra, Jane B. Cryan, Michael Farrell, Petter Brandal, Thale Kristin Olsen, David A. Solomon, Monika Ashok Davare, Lissa Baird, Matthew D. Wood, Barbara Faganel Kotnik, Mara Popović, Shani Caspi, Ho-Keung Ng, Roger Packer, Irene Slavc, Christine Haberler, Matthias Preusser, Tobey J. Macdonald, Paula Z. Proszek, Debbie Hughes, Marc K. Rosenblum, Stephen W. Gilheeney, Ira J. Dunkel, Martin Sill, Simon P. Robinson, Jessica K.R. Boult, Rachael Natrajan, Claire Cairns, Bassel Zebian, Christopher Chandler, Safa Al-Sarraj, Lawrence J. Doey, Andrew J. Martin, Leslie Bridges, Matija Snuderl, David E. Kram, Uwe Kordes, Ulrich Schüller, Jeffrey Knipstein, Stephen Crosier, Mellissa Maybury, Catherine Rowe, Kathreena M. Kurian, Michael Hubank, Ji Wen, Wilda Orisme, James D. Dalton, Kelly Haupfear, Mark Kristiansen, Jane Chalker, Aimee Avery, Amy R. Fairchild, Alex Virasami, Louise Howell, Anna Burford, Valeria Molinari, Diana M. Carvalho, Sara Temelso, Elisa Izquierdo, Iris Stoler, Tejus A. Bale, Scott Newman, Ruth G. Tatevossian, Jessica C. Pickles, Britta Ismer, Alan Mackay, Matthew Clarke
Supplementary Table S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04d97c92485c6eb10e27f5e8a1018f6
https://doi.org/10.1158/2159-8290.22535600
https://doi.org/10.1158/2159-8290.22535600
Autor:
Chris Jones, David T.W. Jones, Thomas S. Jacques, David W. Ellison, Sergey Popov, David Capper, Maria Vinci, Andrea Carai, Angela Mastronuzzi, Suzanne J. Baker, Felix Sahm, Stefan M. Pfister, Christof M. Kramm, Andreas von Deimling, Lynley V. Marshall, Fernando Carceller, Darren R. Hargrave, Kristian Aquilina, Matthias A. Karajannis, David S. Ziegler, Mark J. Cowley, Maria Tsoli, Stephen P. Lowis, Timothy E.G. Hassall, Andrew S. Moore, Simon Bailey, Francesca Diomedi-Camassei, Giovanna Stefania Colafati, Evelina Miele, Clare Mitchell, Tabitha Bloom, Olaf Witt, Marc Zuckermann, Dominik Sturm, Barbara C. Worst, Lotte Hiddingh, Andrey Korshunov, Pablo Hernáiz Driever, Felipe Andreiuolo, Torsten Pietsch, Simone Hettmer, Kornelius Kerl, Winand N.M. Dinjens, Martin Ebinger, Martin U. Schuhmann, Jens Schittenhelm, Michael Karremann, Michael Capra, Jane B. Cryan, Michael Farrell, Petter Brandal, Thale Kristin Olsen, David A. Solomon, Monika Ashok Davare, Lissa Baird, Matthew D. Wood, Barbara Faganel Kotnik, Mara Popović, Shani Caspi, Ho-Keung Ng, Roger Packer, Irene Slavc, Christine Haberler, Matthias Preusser, Tobey J. Macdonald, Paula Z. Proszek, Debbie Hughes, Marc K. Rosenblum, Stephen W. Gilheeney, Ira J. Dunkel, Martin Sill, Simon P. Robinson, Jessica K.R. Boult, Rachael Natrajan, Claire Cairns, Bassel Zebian, Christopher Chandler, Safa Al-Sarraj, Lawrence J. Doey, Andrew J. Martin, Leslie Bridges, Matija Snuderl, David E. Kram, Uwe Kordes, Ulrich Schüller, Jeffrey Knipstein, Stephen Crosier, Mellissa Maybury, Catherine Rowe, Kathreena M. Kurian, Michael Hubank, Ji Wen, Wilda Orisme, James D. Dalton, Kelly Haupfear, Mark Kristiansen, Jane Chalker, Aimee Avery, Amy R. Fairchild, Alex Virasami, Louise Howell, Anna Burford, Valeria Molinari, Diana M. Carvalho, Sara Temelso, Elisa Izquierdo, Iris Stoler, Tejus A. Bale, Scott Newman, Ruth G. Tatevossian, Jessica C. Pickles, Britta Ismer, Alan Mackay, Matthew Clarke
Supplementary Figures and Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65c2845bc3337ffe6dc1ec69cb64973
https://doi.org/10.1158/2159-8290.22535603
https://doi.org/10.1158/2159-8290.22535603
Autor:
Chris Jones, David T.W. Jones, Thomas S. Jacques, David W. Ellison, Sergey Popov, David Capper, Maria Vinci, Andrea Carai, Angela Mastronuzzi, Suzanne J. Baker, Felix Sahm, Stefan M. Pfister, Christof M. Kramm, Andreas von Deimling, Lynley V. Marshall, Fernando Carceller, Darren R. Hargrave, Kristian Aquilina, Matthias A. Karajannis, David S. Ziegler, Mark J. Cowley, Maria Tsoli, Stephen P. Lowis, Timothy E.G. Hassall, Andrew S. Moore, Simon Bailey, Francesca Diomedi-Camassei, Giovanna Stefania Colafati, Evelina Miele, Clare Mitchell, Tabitha Bloom, Olaf Witt, Marc Zuckermann, Dominik Sturm, Barbara C. Worst, Lotte Hiddingh, Andrey Korshunov, Pablo Hernáiz Driever, Felipe Andreiuolo, Torsten Pietsch, Simone Hettmer, Kornelius Kerl, Winand N.M. Dinjens, Martin Ebinger, Martin U. Schuhmann, Jens Schittenhelm, Michael Karremann, Michael Capra, Jane B. Cryan, Michael Farrell, Petter Brandal, Thale Kristin Olsen, David A. Solomon, Monika Ashok Davare, Lissa Baird, Matthew D. Wood, Barbara Faganel Kotnik, Mara Popović, Shani Caspi, Ho-Keung Ng, Roger Packer, Irene Slavc, Christine Haberler, Matthias Preusser, Tobey J. Macdonald, Paula Z. Proszek, Debbie Hughes, Marc K. Rosenblum, Stephen W. Gilheeney, Ira J. Dunkel, Martin Sill, Simon P. Robinson, Jessica K.R. Boult, Rachael Natrajan, Claire Cairns, Bassel Zebian, Christopher Chandler, Safa Al-Sarraj, Lawrence J. Doey, Andrew J. Martin, Leslie Bridges, Matija Snuderl, David E. Kram, Uwe Kordes, Ulrich Schüller, Jeffrey Knipstein, Stephen Crosier, Mellissa Maybury, Catherine Rowe, Kathreena M. Kurian, Michael Hubank, Ji Wen, Wilda Orisme, James D. Dalton, Kelly Haupfear, Mark Kristiansen, Jane Chalker, Aimee Avery, Amy R. Fairchild, Alex Virasami, Louise Howell, Anna Burford, Valeria Molinari, Diana M. Carvalho, Sara Temelso, Elisa Izquierdo, Iris Stoler, Tejus A. Bale, Scott Newman, Ruth G. Tatevossian, Jessica C. Pickles, Britta Ismer, Alan Mackay, Matthew Clarke
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c88928a63f70570ceb077ac4ab638a2
https://doi.org/10.1158/2159-8290.c.6547883.v1
https://doi.org/10.1158/2159-8290.c.6547883.v1
Autor:
Amy R Fairchild, Jessica C Pickles, François Guillemot, Martin Tisdall, Darren Hargrave, Dale Moulding, Simon M. L. Paine, Fatma Scerif, SA Yasin, Thomas S. Jacques, Simon R. Picker, Aimee Avery, Thomas J Stone, Yao-Feng Li, J. Helen Cross, Alex Virasami, William Harkness
Publikováno v:
Neuropathology and Applied Neurobiology. 47:781-795
Aims We understand little of the pathogenesis of developmental cortical lesions, because we understand little of the diversity of the cell types that contribute to the diseases or how those cells interact. We tested the hypothesis that cellular diver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79af7881397542e0975e33b0d02f6ebd
https://doi.org/10.1111/nan.12715
https://doi.org/10.1111/nan.12715
Autor:
Martin Sill, Jessica C Pickles, Abigail F Peary, Mark Kristiansen, David T.W. Jones, Steven C. Clifford, Dariusz Ladon, David A Hilton, Darren Hargrave, SA Yasin, David Capper, Nitika Rathi, Aimee Avery, Olumide Ogunbiyi, Amy R Fairchild, Marie Edwards, Lawrence Doey, Kathreena M Kurian, G. Alistair Lammie, Chris Jones, Antonia Torgersen, Ashirwad Merve, Lorelle Brownlee, Rebecca M Hill, James A. R. Nicoll, Yura Grabovska, Azzam Ismail, Frances Rae, Thomas S. Jacques, Daniel Williamson, Aruna Chakrabarty, Clara Limback-Stanic, Tabitha Bloom, Safa Al-Sarraj, Jamie Gonzalez Zapata, Catherine Rowe, Leslie R. Bridges, Stefan M. Pfister, Carryl Dryden, Saira W. Ahmed, Khaja Syed, Lisa Wilkhu, Colin Smith, Thomas J Stone, Paul N Johns, Andreas von Deimling, Matthew Clarke, Clare Mitchell, Jane Chalker
Publikováno v:
Pickles, J C, Fairchild, A R, Stone, T J, Brownlee, L, Merve, A, Yasin, S A, Avery, A, Ahmed, S W, Ogunbiyi, O, Gonzalez Zapata, J, Peary, A F, Edwards, M, Wilkhu, L, Dryden, C, Ladon, D, Kristiansen, M, Rowe, C, Kurian, K M, Nicoll, J A R, Mitchell, C, Bloom, T, Hilton, D A, Al-Sarraj, S, Doey, L, Johns, P N, Bridges, L R, Chakrabarty, A, Ismail, A, Rathi, N, Syed, K, Lammie, G A, Limback-Stanic, C, Smith, C, Torgersen, A, Rae, F, Hill, R M, Clifford, S C, Grabovska, Y, Williamson, D, Clarke, M, Jones, C, Capper, D, Sill, M, von Deimling, A, Pfister, S M, Jones, D T W, Hargrave, D, Chalker, J & Jacques, T S 2020, ' DNA methylation-based profiling for paediatric CNS tumour diagnosis and treatment : a population-based study ', The Lancet Child and Adolescent Health, vol. 4, no. 2, pp. 121-130 . https://doi.org/10.1016/S2352-4642(19)30342-6
Summary Background Marked variation exists in the use of genomic data in tumour diagnosis, and optimal integration with conventional diagnostic technology remains uncertain despite several studies reporting improved diagnostic accuracy, selection for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83379610827dcf35a669159c2f2b68f3
https://doi.org/10.1016/s2352-4642(19)30342-6
https://doi.org/10.1016/s2352-4642(19)30342-6
Autor:
Michael Karremann, Olaf Witt, Tabitha Bloom, Winand N.M. Dinjens, Felipe Andreiuolo, Michael Farrell, Scott Newman, Simone Hettmer, James Dalton, Leslie R. Bridges, Jens Schittenhelm, Martin Ebinger, Thomas S. Jacques, Francesca Diomedi-Camassei, Dominik Sturm, Jane Chalker, Matija Snuderl, David W. Ellison, Paula Proszek, Irene Slavc, Matthias A. Karajannis, Giovanna Stefania Colafati, Louise Howell, Christine Haberler, Simon Bailey, Barbara C. Worst, David A. Solomon, Andrew J. Martin, Stefan M. Pfister, Maria Vinci, Ho Keung Ng, Kelly Haupfear, Mellissa Maybury, Stephen Gilheeney, Bassel Zebian, Martin Sill, David T.W. Jones, Pablo Hernáiz Driever, Martin U. Schuhmann, Angela Mastronuzzi, Jessica K.R. Boult, Matthew Clarke, Rachael Natrajan, Kornelius Kerl, Lawrence Doey, Alex Virasami, Andrey Korshunov, Christof M. Kramm, Jane Cryan, David E. Kram, Timothy E.G. Hassall, Debbie Hughes, Claire Mitchell, Chris Jones, Monika A. Davare, Evelina Miele, Safa Al-Sarraj, Sara Temelso, Catherine Rowe, Suzanne J. Baker, Sergey Popov, Torsten Pietsch, Matthew D. Wood, Roger J. Packer, Lynley V. Marshall, Michael Capra, Valeria Molinari, Diana Carvalho, Marc Zuckermann, Andreas von Deimling, Uwe Kordes, Kathreena M Kurian, Shani Caspi, Ira J. Dunkel, Wilda Orisme, Ulrich Schüller, Claire Cairns, Matthias Preusser, Kristian Aquilina, Petter Brandal, Stephen Lowis, Iris Stoler, Christopher Chandler, Lissa C. Baird, Marc K. Rosenblum, Ji Wen, Felix Sahm, Barbara Faganel Kotnik, Stephen Crosier, Mara Popović, Andrea Carai, Lotte Hiddingh, Thale Kristin Olsen, Fernando Carceller, Simon P. Robinson, Maria Tsoli, Ruth G. Tatevossian, Anna Burford, Mike Hubank, Elisa Izquierdo, Tejus Bale, David Capper, Andrew S. Moore, David S. Ziegler, Amy R Fairchild, Aimee Avery, Alan Mackay, Jessica C Pickles, Mark Kristiansen, Jeffrey Knipstein, Darren Hargrave, Mark J. Cowley, Tobey J. MacDonald, Britta Ismer
Publikováno v:
Cancer Discovery, 10(7), 942-963. American Association for Cancer Research Inc.
Clarke, M, Mackay, A, Ismer, B, Pickles, J C, Tatevossian, R G, Newman, S, Bale, T A, Stoler, I, Izquierdo, E, Temelso, S, Carvalho, D M, Molinari, V, Burford, A, Howell, L, Virasami, A, Fairchild, A R, Avery, A, Chalker, J, Kristiansen, M, Haupfear, K, Dalton, J D, Orisme, W, Wen, J, Hubank, M, Kurian, K M, Rowe, C & Lowis, S P 2020, ' Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes ', Cancer Discovery . https://doi.org/10.1158/2159-8290.CD-19-1030
Cancer Discov
Clarke, M, Mackay, A, Ismer, B, Pickles, J C, Tatevossian, R G, Newman, S, Bale, T A, Stoler, I, Izquierdo, E, Temelso, S, Carvalho, D M, Molinari, V, Burford, A, Howell, L, Virasami, A, Fairchild, A R, Avery, A, Chalker, J, Kristiansen, M, Haupfear, K, Dalton, J D, Orisme, W, Wen, J, Hubank, M, Kurian, K M, Rowe, C & Lowis, S P 2020, ' Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes ', Cancer Discovery . https://doi.org/10.1158/2159-8290.CD-19-1030
Cancer Discov
Infant high-grade gliomas appear clinically distinct from their counterparts in older children, indicating that histopathologic grading may not accurately reflect the biology of these tumors. We have collected 241 cases under 4 years of age, and carr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::149d27d0bc97b5ac929baad5a7056e03
https://pure.eur.nl/en/publications/16cbcb48-5514-46b8-9f3b-2156ff9b5540
https://pure.eur.nl/en/publications/16cbcb48-5514-46b8-9f3b-2156ff9b5540
Autor:
Lisa Howell, Alan Mackay, Molina Das, Sarita Depani, Simon P. Robinson, Susan Picton, Shaun Wilson, Amy R Fairchild, Maria Vinci, Mike Hubank, Bassel Zebian, Elisa Izquierdo, Elisabet Potente Fernandez, Yura Grabovska, Paula Proszek, Richard Grundy, Jyoti S. Choudhary, Patricia O’Hare, Fernando Carceller, Thomas S. Jacques, Valeria Molinari, Diana Carvalho, Jacques Grill, Jessica K.R. Boult, Rebecca Rogers, Lu Yu, Jenny Adamski, Maria Antonietta Ajmone-Cat, Mark Stubbs, Juliet C. Gray, Georgia Roumelioti, Lynley V. Marshall, Sara Temelso, Darren Hargrave, Giulia Pericoli, Chris Jones, Matthew Clarke
Publikováno v:
Cancer Discov
The survival of children with diffuse intrinsic pontine glioma (DIPG) remains dismal, with new treatments desperately needed. In a prospective biopsy-stratified clinical trial, we combined detailed molecular profiling and drug screening in newly esta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e60f6043d2eaa3b4b1ddd33e84f3949
https://eprints.soton.ac.uk/452227/
https://eprints.soton.ac.uk/452227/