Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Amy R Dwyer"'
Autor:
Stefan Prekovic, Theofilos Chalkiadakis, Merel Roest, Daniel Roden, Catrin Lutz, Karianne Schuurman, Mark Opdam, Liesbeth Hoekman, Nina Abbott, Tanja Tesselaar, Maliha Wajahat, Amy R Dwyer, Isabel Mayayo‐Peralta, Gabriela Gomez, Maarten Altelaar, Roderick Beijersbergen, Balázs Győrffy, Leonie Young, Sabine Linn, Jos Jonkers, Wayne Tilley, Theresa Hickey, Damir Vareslija, Alexander Swarbrick, Wilbert Zwart
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Glucocorticoid receptor (GR) is a transcription factor that plays a crucial role in cancer biology. In this study, we utilized an in silico‐designed GR activity signature to demonstrate that GR relates to the proliferative capacity of nume
Externí odkaz:
https://doaj.org/article/7f89e9b972df425581429cdb0b5d1a09
Autor:
Carlos Jesus Perez Kerkvliet, Amy R Dwyer, Caroline Diep, Robert Oakley, Christopher Liddle, Carol A Lange
Publikováno v:
Journal of Clinical and Translational Science, Vol 4, Pp 7-8 (2020)
OBJECTIVES/GOALS: The glucocorticoid receptor (GR) is a ubiquitous steroid hormone receptor that is emerging as a mediator of breast cancer metastasis. We aim to better understand the biology associated with phospho-GR species in TNBC and their contr
Externí odkaz:
https://doaj.org/article/409bca312f104e95af1b59b8a069adf8
Autor:
Carlos Perez Kerkvliet, Amy R. Dwyer, Caroline H. Diep, Robert H. Oakley, Christopher Liddle, John A. Cidlowski, Carol A. Lange
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-23 (2020)
Abstract Background Altered signaling pathways typify breast cancer and serve as direct inputs to steroid hormone receptor sensors. We previously reported that phospho-Ser134-GR (pS134-GR) species are elevated in triple-negative breast cancer (TNBC)
Externí odkaz:
https://doaj.org/article/1efbfc0a8b594b1c995949a1dcd4afbd
Autor:
Amy R Dwyer, Carlos Perez Kerkvliet, Thu H Truong, Kyla M Hagen, Raisa I Krutilina, Deanna N Parke, Robert H Oakley, Christopher Liddle, John A Cidlowski, Tiffany N Seagroves, Carol A Lange
Publikováno v:
Endocrinology.
Corticosteroids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and are routinely prescribed to breast cancer patients undergoing chemotherapy treatment to alleviate side effects. Triple negative breast cancers (TNBCs) account
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Increased HCK activity in BMDMs supports tumor cell invasion in vitro.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72d0176964ef16bdad891da122661b61
https://doi.org/10.1158/2326-6066.22542897.v1
https://doi.org/10.1158/2326-6066.22542897.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Persistent activation of the latent transcription factor STAT3 is observed in gastric tumor epithelial and immune cells and is associated with a poor patient prognosis. Although targeting STAT3-activating upstream kinases offers therapeutically viabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a55fcba6c2fa63a18d36a4da65f2571
https://doi.org/10.1158/2326-6066.c.6550074.v1
https://doi.org/10.1158/2326-6066.c.6550074.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Constitutive HCK activity in bone marrow-derived cells enhances STAT3 activation in tumors and tumor-associated macrophages.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a74ec4c16f52870e618866ba0774ef
https://doi.org/10.1158/2326-6066.22542900.v1
https://doi.org/10.1158/2326-6066.22542900.v1
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Increased expression of genes associated with alternative macrophage polarization confers a poorer overall survival in human intestinal-type gastric cancer patients.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c074531e7422bd9f135060ddedca8ae
https://doi.org/10.1158/2326-6066.22542894
https://doi.org/10.1158/2326-6066.22542894
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Supplementary Table 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3304b5be5c819c04cdad4eb8b5df768
https://doi.org/10.1158/2326-6066.22542888
https://doi.org/10.1158/2326-6066.22542888
Autor:
Matthias Ernst, Robert J.J. O'Donoghue, Fiona J. Pixley, Tracy L. Putoczki, Clifford A. Lowell, Megan O'Brien, Lachlan Whitehead, Michael W. Murrey, Louis Boon, David Baloyan, Ashwini L. Chand, Moritz F. Eissmann, Amy R. Dwyer, Ashleigh R. Poh
Excessive HCK activity in bone marrow-derived cells promotes STAT3-dependent gastric tumor development and invasion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8167ddff9f96c633329c86a9766a10b8
https://doi.org/10.1158/2326-6066.22542891
https://doi.org/10.1158/2326-6066.22542891