Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Amy Qin"'
Autor:
Hang Cheng, Yiming (Amy) Qin, Rashpal Dhillon, James Dowell, John M. Denu, Matthew E. Pamenter
Publikováno v:
Metabolites, Vol 12, Iss 1, p 56 (2022)
Hypoxia poses a major physiological challenge for mammals and has significant impacts on cellular and systemic metabolism. As with many other small rodents, naked mole-rats (NMRs; Heterocephalus glaber), who are among the most hypoxia-tolerant mammal
Externí odkaz:
https://doaj.org/article/e1e86d843adf47bea4b1e33256cdcdf7
Autor:
Carol E Franz, Jeremy A. Elman, Christine Fennema‐Notestine, Nathan Whitsell, Tsung‐Chin Wu, Xin M Tu, Yongmei Amy Qin, William S. Kremen
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Rashpal S. Dhillon, Yiming (Amy) Qin, Paul R. van Ginkel, Vivian X. Fu, James M. Vann, Alexis J. Lawton, Cara L. Green, Fúlvia B. Manchado‐Gobatto, Claudio A. Gobatto, Dudley W. Lamming, Tomas A. Prolla, John M. Denu
Publikováno v:
Aging Cell. 21
Mitochondrial NAD
Autor:
Rashpal S Dhillon, Yiming (Amy) Qin, Paul R van Ginkel, Vivian X Fu, James M Vann, Alexis J Lawton, Cara L Green, Fúlvia B Manchado-Gobatto, Claudio A Gobatto, Dudley W Lamming, Tomas A Prolla, John M Denu
SummaryMitochondrial NAD+-dependent protein deacetylase Sirtuin3 (SIRT3) has been proposed to mediate calorie restriction (CR)-dependent metabolic regulation and lifespan extension. Here, we investigated the role of SIRT3 in CR-mediated longevity, mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddc4d1399aa317553b2f98a31ffa89f1
https://doi.org/10.1101/2022.05.09.491205
https://doi.org/10.1101/2022.05.09.491205
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Robert Ilaria, Jan Cosaert, Nathan A. Pennell, Amy Qin, Maria Q. Baggstrom, Afshin Dowlati, Ariel Lopez-Chavez, Paul Swanson, Ashwin Shahir, Lucas Wong, Damien M. Cronier, David E. Gerber
Publikováno v:
Lung Cancer. 111:108-115
In non-small cell lung cancer (NSCLC), platelet-derived growth factor receptor (PDGFR) mediates angiogenesis, tissue invasion, and tumor interstitial pressure. Olaratumab (IMC-3G3) is a fully human anti-PDGFRα monoclonal antibody. This Phase II stud
Autor:
R.L. Ilaria, Hans Gelderblom, Amy Qin, Peter Reichardt, Patrick Schöffski, Hans-Georg Kopp, Piotr Rutkowski, Jose A. Lopez-Martin, Hedy L. Kindler, Marc Peeters, Andrew J. Wagner, J. Nippgen, Peter Hohenberger, Sebastian Bauer
Publikováno v:
Annals of Oncology
Annals of Oncology, 28(3), 541-546
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Annals of oncology
Annals of Oncology, 28(3), 541-546
Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Annals of oncology
Background This study evaluated tumor response to olaratumab (an anti-PDGFRα monoclonal antibody) in previously treated patients with metastatic gastrointestinal stromal tumor (GIST) with or without PDGFRα mutations (cohorts 1 and 2, respectively).
Autor:
Douglas Adkins, Damien M. Cronier, Gary K. Schwartz, Gregory K. Pennock, Gaurav D. Shah, Ilaria Conti, Robert Ilaria, Meera Hameed, Ashwin Shahir, Anthony D. Elias, Matthew M. Cooney, Michael B. Livingston, Bartosz Chmielowski, Jan Cosaert, William D. Tap, Amy Qin, Robin L. Jones, Brian A. Van Tine, Mark Agulnik
Publikováno v:
The Lancet. 388:488-497
Summary Background Treatment with doxorubicin is a present standard of care for patients with metastatic soft-tissue sarcoma and median overall survival for those treated is 12–16 months, but few, if any, novel treatments or chemotherapy combinatio
Autor:
Brieuc Sautois, Oliver W. Hakenberg, Amy Qin, Orazio Caffo, Wolfgang Schultze-Seemann, Johannes Nippgen, Tomasz Demkow, Daniel Castellano, Ashwin Shahir, Ruslan D. Novosiadly, Axel Heidenreich, Jose Luis Perez-Gracia, Ivan Pavlik, Tarek Ali, Robert Ilaria
Publikováno v:
European journal of cancer (Oxford, England : 1990). 107
Introduction Platelet-derived growth factor receptor-α (PDGFRα) is expressed in primary prostate adenocarcinoma and in associated skeletal metastases. Olaratumab is a fully human monoclonal antibody that binds PDGFRα and blocks downstream signalli
Autor:
Danni Yu, Siva Rama Prasad Kambhampati, Bert H. O'Neil, E. Gabriela Chiorean, Amy Qin, Bronislaw Pytowski, Muhammad Wasif Saif, John S. Kauh, James A. Knost
Publikováno v:
Cancer chemotherapy and pharmacology. 78(4)
Purpose Metastasis of solid tumors to regional lymph nodes is facilitated by tumor lymphangiogenesis, which is primarily mediated by the vascular endothelial growth factor receptor 3 (VEGFR-3). We conducted a phase 1 dose-escalation (part A) study of