Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Amy Q, Wang"'
Autor:
Rintaro Kato, Wenyu Zeng, Vishal B. Siramshetty, Jordan Williams, Md Kabir, Natalie Hagen, Elias C. Padilha, Amy Q. Wang, Ewy A. Mathé, Xin Xu, Pranav Shah
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Efficiently circumventing the blood-brain barrier (BBB) poses a major hurdle in the development of drugs that target the central nervous system. Although there are several methods to determine BBB permeability of small molecules, the Parallel Artific
Externí odkaz:
https://doaj.org/article/f2af9b80c1964c48b71ae481314f0507
Autor:
Elias C. Padilha, Mengbi Yang, Pranav Shah, Amy Q. Wang, Jianmin Duan, Joshua K. Park, Charles N. Zawatsky, May Christine V. Malicdan, George Kunos, Malliga R. Iyer, Geneviève Gaucher, François Ravenelle, Resat Cinar, Xin Xu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115178- (2023)
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that affects lysosome-related organelles, often leading to fatal pulmonary fibrosis (PF). The search for a treatment for HPS pulmonary fibrosis (HPSPF) is ongoing. S-MRI-1867, a d
Externí odkaz:
https://doaj.org/article/1588916561494097bd24648713f8ed8a
Autor:
Mengbi Yang, Amy Q. Wang, Elias C. Padilha, Pranav Shah, Natalie R. Hagen, China Ryu, Khalida Shamim, Wenwei Huang, Xin Xu
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Niclosamide (Nc) is an FDA-approved anthelmintic drug that was recently identified in a drug repurposing screening to possess antiviral activity against SARS-CoV-2. However, due to the low solubility and permeability of Nc, its in vivo
Externí odkaz:
https://doaj.org/article/7f49f978d6434fb4a382907efaad474b
Autor:
Amy Q. Wang, Natalie R. Hagen, Elias C. Padilha, Mengbi Yang, Pranav Shah, Catherine Z. Chen, Wenwei Huang, Pramod Terse, Philip Sanderson, Wei Zheng, Xin Xu
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Preclinical pharmacokinetics (PK) and In Vitro ADME properties of GS-441524, a potential oral agent for the treatment of Covid-19, were studied. GS-441524 was stable in vitro in liver microsomes, cytosols, and hepatocytes of mice, rats, monkeys, dogs
Externí odkaz:
https://doaj.org/article/96df82be203a4011897c62432885afde
Autor:
Kirill Gorshkov, Amy Q. Wang, Wei Sun, Ethan Fisher, Marta Frigeni, Marc Singleton, Natasha Thorne, Bradley Class, Wenwei Huang, Nicola Longo, Minh‐Ha T. Do, Elizabeth A. Ottinger, Xin Xu, Wei Zheng
Publikováno v:
Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Creatine transporter deficiency (CTD) is a metabolic disorder resulting in cognitive, motor, and behavioral deficits. Cyclocreatine (cCr), a creatine analog, has been explored as a therapeutic strategy for the treatment of CTD. We developed
Externí odkaz:
https://doaj.org/article/5eae92316c67492782ecbd46078cdb8d
Autor:
Amy Q, Wang, Natalie R, Hagen, Elias C, Padilha, Mengbi, Yang, Pranav, Shah, Catherine Z, Chen, Wenwei, Huang, Pramod, Terse, Philip, Sanderson, Wei, Zheng, Xin, Xu
Publikováno v:
Frontiers in pharmacology. 13
Preclinical pharmacokinetics (PK) and
Autor:
Jaclyn N. Highland, Patrick J. Morris, Kylie M. Konrath, Lace M. Riggs, Natalie R. Hagen, Panos Zanos, Chris F. Powels, Ruin Moaddel, Craig J. Thomas, Amy Q. Wang, Todd D. Gould
Publikováno v:
ACS Chem Neurosci
(R,S)-ketamine is rapidly metabolized to form a range of metabolites in vivo, including 12 unique hydroxynorketamines (HNKs) that are distinguished by a cyclohexyl ring hydroxylation at the 4, 5, or 6 position. While both (2R,6R)- and (2S,6S)-HNK rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c839afe123c57e7d8f4dd0148c636fd7
https://europepmc.org/articles/PMC9926475/
https://europepmc.org/articles/PMC9926475/
Autor:
Rupkatha Mukhopadhyay, Sujayita Roy, Rajkumar Venkatadri, Yu-Pin Su, Wenjuan Ye, Elena Barnaeva, Lesley Mathews Griner, Noel Southall, Xin Hu, Amy Q Wang, Xin Xu, Andrés E Dulcey, Juan J Marugan, Marc Ferrer, Ravit Arav-Boger
Publikováno v:
PLoS Pathogens, Vol 12, Iss 6, p e1005717 (2016)
Infection with human cytomegalovirus (HCMV) is a threat for pregnant women and immunocompromised hosts. Although limited drugs are available, development of new agents against HCMV is desired. Through screening of the LOPAC library, we identified eme
Externí odkaz:
https://doaj.org/article/b0195ea1eaba4caab9efda2a3f291a03
Autor:
Jordan Williams, Vishal Siramshetty, Ðắc-Trung Nguyễn, Elias Carvalho Padilha, Md. Kabir, Kyeong-Ri Yu, Amy Q. Wang, Tongan Zhao, Misha Itkin, Paul Shinn, Ewy A. Mathé, Xin Xu, Pranav Shah
Publikováno v:
Bioorg Med Chem
Membrane permeability plays an important role in oral drug absorption. Caco-2 and Madin-Darby Canine Kidney (MDCK) cell culture systems have been widely used for assessing intestinal permeability. Since most drugs are absorbed passively, Parallel Art
Autor:
Karthik, Krishnan, Peter, Ziniel, Hao, Li, Xiuli, Huang, Daniel, Hupalo, Nita, Gombakomba, Sandra Mendoza, Guerrero, Thoai, Dotrang, Xiao, Lu, Diana, Caridha, Anna R, Sternberg, Emma, Hughes, Wei, Sun, Daniel Y, Bargieri, Paul D, Roepe, Richard J, Sciotti, Matthew D, Wilkerson, Clifton L, Dalgard, Gregory J, Tawa, Amy Q, Wang, Xin, Xu, Wei, Zheng, Philip E, Sanderson, Wenwei, Huang, Kim C, Williamson
Publikováno v:
ACS Pharmacol Transl Sci
[Image: see text] Drug resistance is a constant threat to malaria control efforts making it important to maintain a good pipeline of new drug candidates. Of particular need are compounds that also block transmission by targeting sexual stage parasite