Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Amy P, Webster"'
Autor:
Celia Lujan, Eleanor Jane Tyler, Simone Ecker, Amy Philomena Webster, Eleanor Rachel Stead, Victoria Eugenia Martinez-Miguel, Deborah Milligan, James Charles Garbe, Martha Ruskin Stampfer, Stephan Beck, Robert Lowe, Cleo Lucinda Bishop, Ivana Bjedov
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-15 (2024)
Abstract Background Restraining or slowing ageing hallmarks at the cellular level have been proposed as a route to increased organismal lifespan and healthspan. Consequently, there is great interest in anti-ageing drug discovery. However, this curren
Externí odkaz:
https://doaj.org/article/8bc7311ebeed472eb18cda1fe5ab77ae
Autor:
Amy P. Webster, Simone Ecker, Ismail Moghul, Xiaohong Liu, Pawan Dhami, Sarah Marzi, Dirk S. Paul, Michelle Kuxhausen, Stephanie J. Lee, Stephen R. Spellman, Tao Wang, Andrew Feber, Vardhman Rakyan, Karl S. Peggs, Stephan Beck
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Allogeneic hematopoietic cell transplantation (HCT) is used to treat many blood-based disorders and malignancies, however it can also result in serious adverse events, such as the development of acute graft-versus-host disease (aGVHD). This study aim
Externí odkaz:
https://doaj.org/article/951e2cf5b5514896b6ba6afd2a1f92db
Publikováno v:
Endocrine Oncology, Vol 3, Iss 1, Pp 1-9 (2023)
Diabetes and cancer are two heterogenous diseases which are rapidly increasing in prevalence globally. A link between these two non-communicable diseases was first identified over 100 years ago; however, recent epidemiological studies and advances in
Externí odkaz:
https://doaj.org/article/380eb3bf0df6414094580e93dd0ef8dc
Autor:
Athina Dritsoula, Maria Kislikova, Amin Oomatia, Amy P. Webster, Stephan Beck, Markella Ponticos, Ben Lindsey, Jill Norman, David C. Wheeler, Thomas Oates, Ben Caplin
Publikováno v:
Epigenetics, Vol 16, Iss 7, Pp 718-728 (2021)
Chronic kidney disease (CKD) related cardiovascular disease (CVD) is characterized by vascular remodelling with well-established structural and functional changes in the vascular wall such as arterial stiffness, matrix deposition, and calcification.
Externí odkaz:
https://doaj.org/article/f0625af892b84ce089e63ce98d6f558f
Autor:
Amy K Webster, Rojin Chitrakar, Maya Powell, Jingxian Chen, Kinsey Fisher, Robyn E Tanny, Lewis Stevens, Kathryn Evans, Angela Wei, Igor Antoshechkin, Erik C Andersen, L Ryan Baugh
Publikováno v:
eLife, Vol 11 (2022)
Starvation resistance is important to disease and fitness, but the genetic basis of its natural variation is unknown. Uncovering the genetic basis of complex, quantitative traits such as starvation resistance is technically challenging. We developed
Externí odkaz:
https://doaj.org/article/0bf74f246fef489fb08c88cf69117c1d
Autor:
Amanda L Fry, Amy K Webster, Julia Burnett, Rojin Chitrakar, L Ryan Baugh, E Jane Albert Hubbard
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009650 (2021)
Quiescence, an actively-maintained reversible state of cell cycle arrest, is not well understood. PTEN is one of the most frequently lost tumor suppressors in human cancers and regulates quiescence of stem cells and cancer cells. The sole PTEN orthol
Externí odkaz:
https://doaj.org/article/f571a0900f9e4f4899f901ce5b1ca2e1
Autor:
Amy K. Webster, Anthony Hung, Brad T. Moore, Ryan Guzman, James M. Jordan, Rebecca E. W. Kaplan, Jonathan D. Hibshman, Robyn E. Tanny, Daniel E. Cook, Erik Andersen, L. Ryan Baugh
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 10, Pp 3477-3488 (2019)
To understand the genetic basis of complex traits, it is important to be able to efficiently phenotype many genetically distinct individuals. In the nematode Caenorhabditis elegans, individuals have been isolated from diverse populations around the g
Externí odkaz:
https://doaj.org/article/aedd67b78e1245168d3645e4b5015320
Autor:
Stephanie O. M. Dyke, Katie M. Saulnier, Charles Dupras, Amy P. Webster, Karen Maschke, Mark Rothstein, Reiner Siebert, Jörn Walter, Stephan Beck, Tomi Pastinen, Yann Joly
Publikováno v:
Genome Medicine, Vol 11, Iss 1, Pp 1-9 (2019)
Abstract As epigenetic studies become more common and lead to new insights into health and disease, the return of individual epigenetic results to research participants, in particular in large-scale epigenomic studies, will be of growing importance.
Externí odkaz:
https://doaj.org/article/3fcc58747b254ada85d411965fa7bf4e
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100276- (2021)
Summary: Standard laboratory culture of Caenorhabditis elegans utilizes solid growth media with a bacterial food source. However, this culture method limits control of food availability and worm population density, factors that impact many life-histo
Externí odkaz:
https://doaj.org/article/0fba8d0185c544c6a690beb9d4a1d8eb
Autor:
José Afonso Guerra-Assunção, Lucia Conde, Ismail Moghul, Amy P. Webster, Simone Ecker, Olga Chervova, Christina Chatzipantsiou, Pablo P. Prieto, Stephan Beck, Javier Herrero
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
In recent years, there has been a significant increase in whole genome sequencing data of individual genomes produced by research projects as well as direct to consumer service providers. While many of these sources provide their users with an interp
Externí odkaz:
https://doaj.org/article/c4727f28bb4044319d9c29e757800e33