Efficacy and safety of GSK3772847 in participants with moderate-to-severe asthma with allergic fungal airway disease: A phase IIa randomized, multicenter, double-blind, sponsor-open, comparative trial.

Autor: Chika Akinseye, Courtney Crim, Amy Newlands, David Fairman

Publikováno v: PLoS ONE, Vol 18, Iss 2, p e0281205 (2023)

IntroductionCurrent treatments for allergic fungal airway disease are not specific for asthma and are associated with limited efficacy or safety concerns. This Phase IIa randomized, multicenter, double-blind, sponsor-open, comparative trial assessed

Externí odkaz: https://doaj.org/article/7da07e8ad3ae4152bb8c39df3823a468

Inhaler preference comparing two alternative dual bronchodilator regimens

Autor: John H. Riley, William A. Fahy, Margaret Tabberer, Mitra Vahdati-Bolouri, Amy Newlands

Publikováno v: 5.1 Airway Pharmacology and Treatment.

Introduction Simplifying inhaled drug delivery and dosing regimen may improve adherence to medication in chronic respiratory diseases. Many treatment combinations are available and inhaler types differ considerably. This study compared preference acr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edea1892c6660559e5cb40e815ba9fa0
https://doi.org/10.1183/13993003.congress-2016.pa972

Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial

Autor: Kimberley Holt, S Khalid, Rachel Dockry, Amy Newlands, Ashley Woodcock, Robert D. Murdoch, Angela Kelsall, Jaclyn A. Smith, Kevin Smart

Publikováno v: Khalid, S, Murdoch, R, Newlands, A, Smart, K, Kelsall, A, Holt, K, Dockry, R, Woodcock, A & Smith, J A 2014, ' Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial. ', Journal of Allergy and Clinical Immunology, vol. 134, no. 1, pp. 56-62 . https://doi.org/10.1016/j.jaci.2014.01.038
Khalid, S, Murdoch, R, Newlands, A, Smart, K, Kelsall, A, Holt, K, Dockry, R, Woodcock, A & Smith, J A 2014, ' Transient receptor potential vanilloid 1 (TRPV1) antagonism in patients with refractory chronic cough: a double-blind randomized controlled trial. ' Journal of Allergy and Clinical Immunology, vol. 134, no. 1, pp. 56-62 . https://doi.org/10.1016/j.jaci.2014.01.038

Background Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in both animals and human subjects through activation of transient receptor potential vanilloid 1 (TRPV1) on airway sensory nerves. Therefore the TRPV1 receptor is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf9bea0a9f2971adf9e581f8986dc1a5
https://www.research.manchester.ac.uk/portal/en/publications/transient-receptor-potential-vanilloid-1-trpv1-antagonism-in-patients-with-refractory-chronic-cough-a-doubleblind-randomized-controlled-trial(dda43f9c-77fc-4147-a316-a74fb750b8eb).html

Book review: Hauschke D, Steinijans V and Pigeot I 2007: Bioequivalence studies in drug development methods and application. Chichester: John Wiley & Sons Ltd. 311 p. ISBN 978-0-470-09475-4

Autor: Amy Newlands

Publikováno v: Statistical Methods in Medical Research. 18:112-113

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8206b8bd7a8a7357305a0848dd0000a
https://doi.org/10.1177/09622802090180010802

P152 The Impact of a Selective oral TRPV1 Antagonist in Patients with Chronic Cough

Autor: Jacky Smith, Kevin Smart, Rachel Dockry, Kimberley Holt, S Khalid, Robert D. Murdoch, Amy Newlands, Angela Kelsall, Ashley Woodcock

Publikováno v: Thorax. 67:A128.1-A128

Background Increased expression of TRPV1 receptors in the airways of chronic cough patients and heightened cough responses to inhaled capsaicin are suggestive of a role for TRPV1 receptors in chronic cough. We hypothesised that antagonism with a pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f12c259fb3e9223de9d3360ef1949fce
https://doi.org/10.1136/thoraxjnl-2012-202678.213