Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Amy N. Fancher"'
Autor:
Steven V. O’Neil, Biswanath De, Christopher D. Ellis, Charles A. Cruze, Mark William Baize, Thomas P. Demuth, Laufersweiler Michael Christopher, Maria Buchalova, Wei Lu, Richard L. Wang, Marina Belkin, Amy N. Fancher, Maureen K. Suchanek, John August Wos, David Lindsey Soper, William P. Schwecke, Kofi A. Oppong, Yili Wang
Publikováno v:
Bioorganic & Medicinal Chemistry. 15:1311-1322
Peptidomimetic compounds possessing a caprolactam ring constraint were prepared and evaluated as interleukin-1beta converting enzyme (ICE) inhibitors. The caprolactam ring was used to constrain the P3 region of our inhibitors. This strategy proved to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71a480f259f627a783c9ada672da248
https://doi.org/10.1016/j.bmc.2006.11.011
https://doi.org/10.1016/j.bmc.2006.11.011
Autor:
David Lindsey Soper, John August Wos, Kofi A. Oppong, Richard L. Wang, Biswanath De, Laufersweiler Michael Christopher, Thomas P. Demuth, Wei Lu, Steven V. O’Neil, Maureen K. Suchanek, Christopher D. Ellis, Amy N. Fancher, Yili Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:4728-4732
A series of monocyclic thiazepine inhibitors of interleukin-1β converting enzyme (ICE) were synthesized in eight steps from commercially available intermediates. In vitro biological evaluation showed the thiazepines to be moderately potent ICE inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a6295e34134eb99771fc41c3af1397
https://doi.org/10.1016/j.bmcl.2006.07.016
https://doi.org/10.1016/j.bmcl.2006.07.016
Autor:
Amy N. Fancher, Mark William Baize, Thomas P. Demuth, Kofi A. Oppong, Yili Wang, David Lindsey Soper, Steven V. O’Neil, Richard L. Wang, Wei Lu, Christopher D. Ellis, Maureen K. Suchanek, John August Wos, Gregory K. Bosch, Laufersweiler Michael Christopher, Biswanath De
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5434-5438
Two novel 8,6-fused bicyclic peptidomimetic ring systems were synthesized utilizing olefin metathesis as the key reaction for the formation of the eight-membered ring. Both peptidomimetic scaffolds were further elaborated into potent ICE inhibitors,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd938c33c63edb10816a75996d4f78bc
https://doi.org/10.1016/j.bmcl.2005.08.109
https://doi.org/10.1016/j.bmcl.2005.08.109
Autor:
Mark William Baize, Thomas P. Demuth, Yili Wang, Steven V. O’Neil, Maureen K. Suchanek, John August Wos, David Lindsey Soper, Wei Lu, Laufersweiler Michael Christopher, Kofi A. Oppong, Christopher D. Ellis, Amy N. Fancher, Richard L. Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4322-4326
The application of a tricyclic pyrrolopyrimidinone scaffold for the synthesis of peptidomimetic inhibitors of interleukin-1β-converting enzyme (ICE) is reported. The synthesis of the tricyclic scaffold and conversion of it to a variety of target ICE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad66fe44b462960298f4c0d707ffcd24
https://doi.org/10.1016/j.bmcl.2005.06.046
https://doi.org/10.1016/j.bmcl.2005.06.046
Autor:
Christopher D. Ellis, Jack J. Chen, Amanda L. Ritter, David Lindsey Soper, Justin Sheville, Biswanath De, Maureen K. Suchanek, William P. Schwecke, Laufersweiler Michael Christopher, Amy N. Fancher, Richard L. Wang, Charles A. Cruze, Marina Belkin, Kofi A. Oppong, Mark William Baize, Thomas P. Demuth, John August Wos, Yili Wang, Fred C. Wireko, Wei Lu, Steven V. O’Neil, Maria Buchalova, Difei Wang
Publikováno v:
Bioorganicmedicinal chemistry. 14(23)
An 8,5-fused bicyclic peptidomimetic ring system generated by a stereoselective ring metathesis reaction was elaborated into potent inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1). Multiple compounds were found that exhibited ICE I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e94287f11e63976f2bae9807b3e43730
https://pubmed.ncbi.nlm.nih.gov/16908171
https://pubmed.ncbi.nlm.nih.gov/16908171
Autor:
Yili Wang, Richard L. Wang, Maureen K. Suchanek, Thomas P. Demuth, David Lindsey Soper, Justin Sheville, Kofi A. Oppong, Steven V. O’Neil, Wei Lu, John August Wos, Laufersweiler Michael Christopher, Amy N. Fancher, Biswanath De, Christopher D. Ellis
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(16)
Novel 1-(2-acylhydrazinocarbonyl)cycloalkyl carboxamides were designed as peptidomimetic inhibitors of interleukin-1beta converting enzyme (ICE). A short synthesis was developed and moderately potent ICE inhibitors were identified (IC(50) values100 n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa9060c5aa9019da47ece784be81b21a
https://pubmed.ncbi.nlm.nih.gov/16782334
https://pubmed.ncbi.nlm.nih.gov/16782334
Autor:
Laufersweiler Michael Christopher, Richard L. Wang, Gregory K. Bosch, Steven V. O’Neil, Christopher D. Ellis, Yili Wang, Mark William Baize, Thomas P. Demuth, John August Wos, Maureen K. Suchanek, Amy N. Fancher, Wei Lu, David Lindsey Soper, Kofi A. Oppong, Biswanath De
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(19)
A novel diazocan containing dipeptide mimetic was synthesized via reductive N-N bond cleavage of a pyrazolidino-pyrazolidine using Raney-Ni and evaluated as an ICE inhibitor. This versatile 8-membered ring containing scaffold possesses an N-5 ring ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7a6640841313d07e21cf0de234da9c
https://pubmed.ncbi.nlm.nih.gov/16046125
https://pubmed.ncbi.nlm.nih.gov/16046125