Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Amy N Suthers"'
Autor:
Jonathan C. Poe, Jiyuan Fang, Dadong Zhang, Marissa R. Lee, Rachel A. DiCioccio, Hsuan Su, Xiaodi Qin, Jennifer Y. Zhang, Jonathan Visentin, Sonali J. Bracken, Vincent T. Ho, Kathy S. Wang, Jeremy J. Rose, Steven Z. Pavletic, Frances T. Hakim, Wei Jia, Amy N. Suthers, Itaevia M. Curry-Chisolm, Mitchell E. Horwitz, David A. Rizzieri, William C. McManigle, Nelson J. Chao, Adela R. Cardones, Jichun Xie, Kouros Owzar, Stefanie Sarantopoulos
Publikováno v:
JCI Insight, Vol 8, Iss 11 (2023)
Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT), chronic graft-versus-host disease (cGVHD), a B cell–associated autoimmune-like syndrome, commonly occurs. Because donor-derived B ce
Externí odkaz:
https://doaj.org/article/6512c743367141a7ad578b252db65faa
Autor:
Amy N. Suthers, Stefanie Sarantopoulos
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
B cells are capable of receptor-mediated responses to foreign antigens. Recognition of microbial-derived nucleic acid (NA) by toll-like receptors (TLRs) 7 and 9 in B cells has been substantiated. Endogenous NA released from damaged or dying cells can
Externí odkaz:
https://doaj.org/article/b17458998a3d40a0b7ea79f548bc2903
Autor:
Jonathan C Poe, Jiyuan Fang, Dadong Zhang, Marissa R Lee, Rachel A DiCioccio, Hsuan Su, Xiaodi Qin, Jennifer Zhang, Jonathan Visentin, Sonali J Bracken, Vincent T Ho, Kathy S Wang, Jeremy J Rose, Steven Z Pavletic, Frances T Hakim, Wei Jia, Amy N Suthers, Itaevia Curry-Chisolm, Mitchell E Horwitz, David A Rizzieri, William McManigle, Nelson J Chao, Adela R Cardones, Jichun Xie, Kouros Owzar, Stefanie Sarantopoulos
Alloreactivity can drive autoimmune syndromes. After allogeneic hematopoietic stem cell transplantation (allo-HCT) chronic graft-versus-host disease (cGVHD), a B cell-mediated autoimmune-like syndrome, commonly occurs. Because donor-derived B cells c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c473db4c87738c7f0e79af6c6c5d1f7b
https://doi.org/10.1101/2022.10.13.512162
https://doi.org/10.1101/2022.10.13.512162
Autor:
Daniel R. Saban, Jonathan C. Poe, Vedran Radojcic, Diana M. Cardona, Ivan Maillard, Stefanie Sarantopoulos, Amy N. Suthers, Itaevia M. Curry-Chisolm, Hsuan Su, Glenn K. Matsushima, Zhiguo Li, Sarah Anand, Wei Jia, Jeffrey C. Rathmell, Nelson J. Chao, Kazuhiro Imai, Nancy J. Reyes, Benny J. Chen, Rachel A. DiCioccio
Publikováno v:
Blood. 137:2544-2557
Patients with chronic graft-versus-host disease (cGVHD) have increased B cell–activating factor (BAFF) levels, but whether BAFF promotes disease after allogeneic bone marrow transplantation (allo-BMT) remains unknown. In a major histocompatibility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be17ccdd1a98354e92e354cd941e9d6
https://doi.org/10.1182/blood.2020008040
https://doi.org/10.1182/blood.2020008040
Publikováno v:
International Journal of Immunogenetics. 43:209-217
In mammals, interleukin-21 is a member of the common gamma chain cytokine family that also includes IL-2, IL-4, IL-7, IL-9 and IL-15. IL-21 has pleiotropic effects on both myeloid and lymphoid immune cells and as a consequence, the biological actions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0c0ca7c4981c86fe0a46a0a3854fb07
https://doi.org/10.1111/iji.12272
https://doi.org/10.1111/iji.12272
Autor:
Nelson J. Chao, Jiyuan Fang, Vincent T. Ho, Kouros Owzar, Frances T. Hakim, David A. Rizzieri, Jichun Xie, William C McManigle, Jeremy J. Rose, Dadong Zhang, Wei Jia, Mitchell E. Horwitz, Steven Z. Pavletic, Rachel A. DiCioccio, Xiaodi Qin, Jonathan C. Poe, Stefanie Sarantopoulos, Amy N. Suthers
Publikováno v:
Blood. 134:874-874
While B cells are known to contribute to the pathogenesis of chronic graft-versus-host disease (cGVHD) in mice, it has been challenging to elucidate intrinsic mechanisms of tolerance loss in patients. To identify distinct and potentially targetable B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ae03bb53201e93e4bee470150df2780
https://doi.org/10.1182/blood-2019-130928
https://doi.org/10.1182/blood-2019-130928
Autor:
William C McManigle, Gwynn D. Long, Sarah Anand, David A. Rizzieri, Nelson J. Chao, Julia M. Lloyd-Cowden, Krista Rowe Nichols, Kelly Corbet, Zhiguo Li, Wei Jia, Mitchell E. Horwitz, Cristina Gasparetto, Jonathan C. Poe, Rachel A. DiCioccio, Stefanie Sarantopoulos, Amy N. Suthers, Richard D. Lopez, Megan Covington, Anthony D. Sung
Publikováno v:
Blood. 134:4521-4521
Our group previously showed that B cells signal aberrantly through the B cell receptor (BCR) in allogeneic hematopoietic stem cell transplant (HCT) patients with active chronic graft-versus-host disease (cGVHD). Preclinical mouse studies have demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68cb6ec6763c1af0047ea6f4b7db9355
https://doi.org/10.1182/blood-2019-130742
https://doi.org/10.1182/blood-2019-130742
Autor:
Lauren J. Young, Amy N. Suthers
Publikováno v:
Molecular Immunology. 55:310-318
Lyn is a tyrosine kinase molecule required for modulation of signalling cascades in cell populations including B lymphocytes of the mammalian immune system. We have characterised the coding domain of the marsupial lyn gene of two macropod marsupials;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b0eff9586d3c996fedd2a86c07c2b5
https://doi.org/10.1016/j.molimm.2013.03.003
https://doi.org/10.1016/j.molimm.2013.03.003
Autor:
Sarah Anand, Pei Fen Kuan, Corbin D. Jones, Benjamin G. Vincent, Jonathan C. Poe, Christian W. Siebel, Prasanthi V. Tata, Kouros Owzar, Nelson J. Chao, Frances T. Hakim, Ivan Maillard, Steven Z. Pavletic, Jeremy J. Rose, Jonathan S. Serody, Wei Jia, Mitchell E. Horwitz, Dadong Zhang, Bruce R. Blazar, Vincent T. Ho, Stefanie Sarantopoulos, Amy N. Suthers, Hsuan Su
B-cell receptor (BCR)-activated B cells contribute to pathogenesis in chronic graft-versus-host disease (cGVHD), a condition manifested by both B-cell autoreactivity and immune deficiency. We hypothesized that constitutive BCR activation precluded fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bbbf78c270258a22a2a10257d3e422
Autor:
Jonathan C. Poe, Stefanie Sarantopoulos, Amy N. Suthers, Hsuan Su, Nelson J. Chao, Sarah Anand, Yiping Yang, David A. Rizzieri, Jeremy J. Rose, Steven Z. Pavletic, Frances T. Hakim, Mitchell E. Horwitz
Publikováno v:
Blood. 130:75-75
After hematopoietic allogeneic stem cell transplantation (HCT), B cells reconstitute in the presence of alloantigen in a nucleic acid (NA)-rich environment. Ongoing tissue and cellular damage results in release of endogenous NA that may serve as liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25fd2036b156e8dc285e4729e3ec55f1
https://doi.org/10.1182/blood.v130.suppl_1.75.75
https://doi.org/10.1182/blood.v130.suppl_1.75.75