Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Amy N Sinclair"'
Autor:
Amy N Sinclair, Christine T Huynh, Thomas E Sladewski, Jenna L Zuromski, Amanda E Ruiz, Christopher L de Graffenried
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009588 (2021)
Microtubules are inherently dynamic cytoskeletal polymers whose length and organization can be altered to perform essential functions in eukaryotic cells, such as providing tracks for intracellular trafficking and forming the mitotic spindle. Microtu
Externí odkaz:
https://doaj.org/article/29c6e0251cbf4e09a0aec23fb7874b9d
Publikováno v:
Current biology : CB. 32(6)
How well do we understand the range of mechanisms used by eukaryotes for mitosis? A new study in a highly divergent eukaryote shows that unusual tubulin isoforms can create a mitotic spindle exclusively out of microtubule bundles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de4c9313dba538567ca807909a560878
https://pubmed.ncbi.nlm.nih.gov/35139359
https://pubmed.ncbi.nlm.nih.gov/35139359
Publikováno v:
Molecular biology of the cell. 33(1)
IQGAP is a conserved family of actin-binding proteins with essential roles in cell motility, cytokinesis, and cell adhesion, yet there remains a limited understanding of how IQGAP proteins directly influence actin filament dynamics. To close this gap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::482d22e8af4a08fa4be9704d26509af1
https://pubmed.ncbi.nlm.nih.gov/34731043
https://pubmed.ncbi.nlm.nih.gov/34731043
Autor:
Amanda E. Ruiz, Thomas E. Sladewski, Christopher L. de Graffenried, Christine T. Huynh, Amy N. Sinclair, Jenna Zuromski
Microtubules are inherently dynamic cytoskeletal polymers whose length and activity can be altered to perform essential functions in eukaryotic cells, such as providing tracks for intracellular trafficking and forming the mitotic spindle. Microtubule
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ded3cde4021ff42e4fadee8ed1ee1505
https://doi.org/10.1101/2020.11.09.375725
https://doi.org/10.1101/2020.11.09.375725
Autor:
Margaret M. Suhanovsky, Cheng Zhang, Alexandra M. Deaconescu, Amy N. Sinclair, Dmitry Lyumkis, David D. Kim, Christiane Brugger
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mfd couples transcription to nucleotide excision repair, and acts on RNA polymerases when elongation is impeded. Depending on impediment severity, this action results in either transcription termination or elongation rescue, which rely on ATP-depende
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f73994e9bf86cf0c22f635ec544438fc
https://doi.org/10.1038/s41467-020-17457-1
https://doi.org/10.1038/s41467-020-17457-1
Autor:
Jenna A. Perry, Zemplen Pataki, Nicholas A. Hilton, Jenna I. Wurster, Richard S. Muniz, Jiwon Seo, Amy N. Sinclair-Davis, Thomas E. Sladewski, Christopher L. de Graffenried, Holly L. Tran
Publikováno v:
Molecular Microbiology. 109:306-326
The protist parasite Trypanosoma brucei is an obligate extracellular pathogen that retains its highly polarized morphology during cell division and has evolved a novel cytokinetic process independent of non-muscle myosin II. The polo-like kinase homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9f951c697e4b974bd1731f794feabcb
https://doi.org/10.1111/mmi.13986
https://doi.org/10.1111/mmi.13986
Publikováno v:
Molecular Microbiology. 107:344-362
Trypanosoma brucei uses multiple mechanisms to evade detection by its insect and mammalian hosts. The flagellar pocket (FP) is the exclusive site of uptake from the environment in trypanosomes and shields receptors from exposure to the host. The FP n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::594ede2dc0ca9fb2941ff7f46e480091
https://doi.org/10.1111/mmi.13885
https://doi.org/10.1111/mmi.13885
The parasite Trypanosoma brucei is highly polarized, including a flagellum that is attached along the cell surface by the flagellum attachment zone (FAZ). During cell division, the new FAZ positions the cleavage furrow, which ingresses from the anter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0afd37e05e6f1a805f29876b55d19189
https://europepmc.org/articles/PMC5702046/
https://europepmc.org/articles/PMC5702046/
Autor:
Nicholas A. Hilton, Amy N. Sinclair-Davis, Christopher L. de Graffenried, Michael R. McAllaster
Trypanosoma brucei is the causative agent of human African trypanosomiasis and nagana in cattle. Recent advances in high throughput phenotypic and interaction screens have identified a wealth of novel candidate proteins for diverse functions such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec96534f50c0135f0dbbd0e920b947d
https://europepmc.org/articles/PMC5125862/
https://europepmc.org/articles/PMC5125862/
Publikováno v:
Biochemistry. 53(1)
Asymmetric diadenosine 5',5‴-P(1),P(4)-tetraphosphate (Ap4A) hydrolases are members of the Nudix superfamily that asymmetrically cleave the metabolite Ap4A into ATP and AMP while facilitating homeostasis. The obligate intracellular mammalian pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d6638d04dc835d5b7a4ce7f7e483a85
https://pubmed.ncbi.nlm.nih.gov/24354275
https://pubmed.ncbi.nlm.nih.gov/24354275