Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Amy Musto"'
Publikováno v:
Steroids. 71:578-584
Progesterone receptor modulators have diverse potential therapeutic uses, including the treatment of endometriosis, uterine fibroids and breast cancer. Here we describe the molecular properties and preclinical pharmacology of a new steroidal progesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172851d492a081951efad7cc11eef8ea
https://doi.org/10.1016/j.steroids.2006.02.002
https://doi.org/10.1016/j.steroids.2006.02.002
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:3233-3237
A novel series of tetracyclic indoles have been designed, synthesized and evaluated as androgen receptor (AR) ligands. Studies of structure-activity relationships (SARs) were investigated, which led to some compounds in this series as strong binders
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9c27418964677c00687d92347b1fc19
https://doi.org/10.1016/j.bmcl.2006.03.047
https://doi.org/10.1016/j.bmcl.2006.03.047
Autor:
Fuyong Du, George F. Allan, Ramesh M. Kanojia, Nareshkumar F. Jain, Zhihua Sui, Amy Musto, Emmanuel Pacia, Muh-Tsann Lai, Guo Jian-Zhong, Jiayi Xu, DoWon Hahn, and Scott Lundeen
Publikováno v:
Journal of Medicinal Chemistry. 49:3056-3059
A novel SERM (selective estrogen receptor modulators), 1-(R), a chromene-derived bisbenzopyran, was discovered to alleviate hot flushes and effectively increase vaginal fluidity in rats. Moreover, 1-(R) was found to have beneficial effects on plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e23139ff8b9adfb003d6086a95b0ff
https://doi.org/10.1021/jm060353u
https://doi.org/10.1021/jm060353u
Autor:
Ronald K. Russell, Martin Cousineau, Scott G. Lundeen, DoWon Hahn, Ramesh M. Kanojia, Nareshkumar F. Jain, David M. Ritchie, Muh-Tsann Lai, Guo Jian-Zhong, Xun Li, George F. Allan, Emmanuel Pacia, Jiayi Xu, Sean Peng, Fuyong Du, Zhihua Sui, Amy Musto, Michael Reuman
Publikováno v:
Journal of medicinal chemistry. 52(23)
As part of a program aimed at the development of selective estrogen receptor modulators (SERMs), novel chromene scaffolds, benzopyranobenzoxapanes, were discovered. Many compounds showed binding affinity as low as 1.6-200 nM, displayed antagonist beh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a373fd7e9d9cd82671bd1a5edd0cc8d
https://pubmed.ncbi.nlm.nih.gov/19366247
https://pubmed.ncbi.nlm.nih.gov/19366247
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(21)
Two potential bioisosteres of the nonsteroidal antiandrogen bicalutamide, an imidazolidinone and an indole, were synthesized and tested for their androgen receptor binding. Indole was discovered to be a suitable bioisostere for the acyl anilide moiet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23401da8a63519bd63d67ae43662b26b
https://pubmed.ncbi.nlm.nih.gov/16942875
https://pubmed.ncbi.nlm.nih.gov/16942875
Autor:
Nareshkumar Jain, Jiayi Xu, Ramesh M. Kanojia, Fuyong Du, Guo Jian-Zhong, Emmanuel Pacia, Muh-Tsann Lai, Amy Musto, George Allan, Michael Reuman, Xun Li, DoWon Hahn, Martin Cousineau, Sean Peng, David Ritchie, Ronald Russell, Scott Lundeen, Zhihua Sui
Publikováno v:
Journal of Medicinal Chemistry; Dec2009, Vol. 52 Issue 23, p7544-7569, 26p