Výsledky vyhledávání - "Amy McCart-Reed"

Akademický článek

TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells

Autor: Alice H. L. Bong, Mélanie Robitaille, Sichun Lin, Amy McCart-Reed, Michael Milevskiy, Stéphane Angers, Sarah J. Roberts-Thomson, Gregory R. Monteith

Publikováno v: Cell Death Discovery, Vol 10, Iss 1, Pp 1-12 (2024)

Abstract The release of Ca2+ ions from endoplasmic reticulum calcium stores is a key event in a variety of cellular processes, including gene transcription, migration and proliferation. This release of Ca2+ often occurs through inositol 1,4,5-triphos

Externí odkaz: https://doaj.org/article/621bb704143344139070befe42b1c5d8

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Akademický článek

Editorial: Molecular mechanisms in breast cancer progression and metastasis

Autor: Monica Fedele, Amy McCart Reed

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

Externí odkaz: https://doaj.org/article/47422c0e8ed143cd8694f2f7b85a855a

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BRCA1 and BRCA2 carriers with breast, ovarian and prostate cancer demonstrate a different pattern of metastatic disease compared with non‐carriers: results from a rapid autopsy programme

Publikováno v: Histopathology.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46de9523d500a222c87ce67cd436cdb1
https://doi.org/10.1111/his.14906

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Obesity-associated changes in molecular biology of primary breast cancer

Autor: Christine Desmedt, Ha-Linh Nguyen, Tatjana Geukens, Marion Maetens, Samuel Aparicio, Ayse Bassez, Åke Borg, Jane Brock, Annegien Broeks, Carlos Caldas, Fatima Cardoso, Maxim De Schepper, Mauro Delorenzi, Caroline Drukker, Annuska Glas, Andrew Green, Edoardo Isnaldi, Jórunn Eyfjörd, Hazem Khout, Stian Knappskog, Savitri Krishnamurthy, Sunil Lakhani, Anita Langerod, John Martens, Amy McCart Reed, Leigh Murphy, Stefan Naulaerts, Serena Nik-Zainal, Ines Nevelsteen, Patrick Neven, Martine Piccart, Coralie Poncet, Kevin Punie, Colin Purdie, Emad Rakha, Andrea Richardson, Emiel Rutgers, Anne Vincent-Salomon, Peter Simpson, Marjanka Schmidt, Christos Sotiriou, Paul Span, Kiat Tee Benita Tan, Alastair Thompson, Stefania Tommasi, Karen Van Baelen, Marc van de Vijver, Steven Van Laere, Laura Van 'T Veer, Giuseppe Viale, Alain Viari, Hanne Vos, Anke Witteveen, Hans Wildiers, Giuseppe Floris, Abhishek Garg, Ann Smeets, Diether Lambrechts, Elia Biganzoli, François Richard

Worldwide, there is a growing proportion of women who are overweight or obese. While obesity has been associated with an increased risk of developing breast cancer (BC) and worse prognosis in BC patients, yet the impact of adiposity (abnormal or exce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58b54596187c11d4d6b92cc582c86733
https://doi.org/10.21203/rs.3.rs-2377863/v1

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Hereditary breast cancer: syndromes, tumour pathology and molecular testing

Autor: Amy McCart Reed, Sunil Lakhani, Peter Simpson, Kate Johnstone, Anna Sokolova

Publikováno v: HistopathologyReferences. 82(1)

Hereditary factors account for a significant proportion of breast cancer risk. Approximately 20% of hereditary breast cancers are attributable to pathogenic variants in the highly penetrant BRCA1 and BRCA2 genes. A proportion of the genetic risk is a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d713c347c30b386f134c2b9190d2f7
https://pubmed.ncbi.nlm.nih.gov/36468211

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Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Autor: Sunil R. Lakhani, Jodi Saunus, Kristofer Thurecht, Melanie Flint, Amy McCart Reed, Nicholas Fletcher, Malcolm Lim

Publikováno v: Journal of Visualized Experiments.

Brain metastasis is a cause of severe morbidity and mortality in cancer patients. Critical aspects of metastatic diseases, such as the complex neural microenvironment and stromal cell interaction, cannot be entirely replicated with in vitro assays; t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebadf81a81e082de049909050ef52dc
https://doi.org/10.3791/64216

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Akademický článek

Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib.

Autor: Darrell C Bessette, Erik Tilch, Tatjana Seidens, Michael C J Quinn, Adrian P Wiegmans, Wei Shi, Sibylle Cocciardi, Amy McCart-Reed, Jodi M Saunus, Peter T Simpson, Sean M Grimmond, Sunil R Lakhani, Kum Kum Khanna, Nic Waddell, Fares Al-Ejeh, Georgia Chenevix-Trench

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125232 (2015)

Basal-like and triple negative breast cancer (TNBC) share common molecular features, poor prognosis and a propensity for metastasis to the brain. Amplification of epidermal growth factor receptor (EGFR) occurs in ~50% of basal-like breast cancer, and

Externí odkaz: https://doaj.org/article/1aeb5efb8fdc47a187350d3ae92f42ba

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Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib

Autor: Michael C.J. Quinn, Adrian P. Wiegmans, Jodi M. Saunus, Nic Waddell, Tatjana Seidens, Sean M. Grimmond, Darrell C. Bessette, Sunil R. Lakhani, Fares Al-Ejeh, Amy McCart-Reed, Georgia Chenevix-Trench, Wei Shi, Kum Kum Khanna, Sibylle Cocciardi, Peter T. Simpson, Erik Tilch

Publikováno v: PLoS ONE, Vol 10, Iss 5, p e0125232 (2015)
PLoS ONE

Background Basal-like and triple negative breast cancer (TNBC) share common molecular features, poor prognosis and a propensity for metastasis to the brain. Amplification of epidermal growth factor receptor (EGFR) occurs in ~50% of basal-like breast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d545051c1632b7d4fd9ea9769435cd62
http://europepmc.org/articles/PMC4430383?pdf=render

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