Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Amy Madison Rhoden Smith"'
Autor:
Wood Kristy M, Corey Ciullo, William Salomon, Finn Jonathan Douglas, Amy Madison Rhoden Smith, Jacqueline Growe, Dandan Ling, Reynald Lescarbeau, Youniss Madeleine, David V. Morrissey, Jessica Seitzer, Ellen Rohde, Tanner Dirstine, Ruchi Rudraprasad Shah, Lucinda Shaw, Melissa Pink, Mihir Patel, Christian Dombrowski, Chang Yong, Jane van Heteren, Aalok Shah, William F. Harrington, Walter Strapps
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2227-2235 (2018)
Summary: The development of clinically viable delivery methods presents one of the greatest challenges in the therapeutic application of CRISPR/Cas9 mediated genome editing. Here, we report the development of a lipid nanoparticle (LNP)-mediated deliv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0719aa81c3c1549aa7f9d9969ec3d6
http://www.sciencedirect.com/science/article/pii/S2211124718301827
http://www.sciencedirect.com/science/article/pii/S2211124718301827
Publikováno v:
Journal of the American Chemical Society. 135:12783-12789
The development of small molecules that bind DNA sequence specifically has the potential to modulate gene expression in a general way. One mode of DNA binding is intercalation, or the insertion of molecules between DNA base pairs. We have developed a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23a94b95cadf4fcc025f7fb53ee8bf6d
https://doi.org/10.1021/ja4057344
https://doi.org/10.1021/ja4057344
Naphthalene diimide (NDI) has been widely studied as a DNA threading intercalator. While an intercalator binds DNA by insertion in between base pairs, a threading intercalator also binds with substituents residing simultaneously in the DNA major and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::435543dde89da1b93a46b515d8dcab57
https://doi.org/10.1039/9781782621386-00037
https://doi.org/10.1039/9781782621386-00037
Autor:
Garen G. Holman, Amy Madison Rhoden Smith, Maha Zewail-Foote, Brent L. Iverson, Kenneth A. Johnson
Publikováno v:
Nature chemistry
A long-lived and sequence specific ligand-DNA complex would make possible the modulation of biological processes for extended periods. We have been investigating the threading polyintercalation approach to DNA recognition in which chains of aromatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51009b8470235ac1ad2c756bca7de9e
http://europepmc.org/articles/PMC3209807
http://europepmc.org/articles/PMC3209807
Publikováno v:
Biochemistry
Small molecules that bind DNA in a sequence-specific manner could act as antibiotic, antiviral, or anticancer agents because of their potential ability to manipulate gene expression. Our laboratory has developed threading polyintercalators based on 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7613b0a2fd848277a7eb5119c4a860e2
https://pubmed.ncbi.nlm.nih.gov/22554127
https://pubmed.ncbi.nlm.nih.gov/22554127